Circulating nucleic acids as biomarkers in breast cancer
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Circulating nucleic acids as biomarkers in breast cancer. / Schwarzenbach, Heidi.
In: BREAST CANCER RES, Vol. 15, No. 5, 01.01.2013, p. 211.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Circulating nucleic acids as biomarkers in breast cancer
AU - Schwarzenbach, Heidi
PY - 2013/1/1
Y1 - 2013/1/1
N2 - During tumor development, tumor cells release their nucleic acids into the blood circulation. This process occurs by apoptotic and necrotic cell deaths along with active cell secretion, resulting in high levels of circulating DNA, mRNA, and microRNA in the blood of patients with breast cancer. As circulating cell-free tumor nucleic acids may reflect the characteristics of the primary tumor and even of micrometastatic cells, they may be excellent blood biomarkers for screening breast cancer. Assays that allow the repetitive monitoring of patients by using blood samples as liquid biopsy may be efficient in assessing cancer progression in patients whose tumor tissue is not available. This review evaluates the recent data on the potential use of circulating cell-free nucleic acids as biomarkers for breast cancer.
AB - During tumor development, tumor cells release their nucleic acids into the blood circulation. This process occurs by apoptotic and necrotic cell deaths along with active cell secretion, resulting in high levels of circulating DNA, mRNA, and microRNA in the blood of patients with breast cancer. As circulating cell-free tumor nucleic acids may reflect the characteristics of the primary tumor and even of micrometastatic cells, they may be excellent blood biomarkers for screening breast cancer. Assays that allow the repetitive monitoring of patients by using blood samples as liquid biopsy may be efficient in assessing cancer progression in patients whose tumor tissue is not available. This review evaluates the recent data on the potential use of circulating cell-free nucleic acids as biomarkers for breast cancer.
U2 - 10.1186/bcr3446
DO - 10.1186/bcr3446
M3 - SCORING: Journal article
C2 - 24090167
VL - 15
SP - 211
JO - BREAST CANCER RES
JF - BREAST CANCER RES
SN - 1465-5411
IS - 5
ER -