Circulating nucleic acids and protease activities in blood of tumor patients.
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Circulating nucleic acids and protease activities in blood of tumor patients. / Schwarzenbach, Heidi.
In: EXPERT OPIN BIOL TH, Vol. 12 Suppl 1, 2012, p. 163-169.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Circulating nucleic acids and protease activities in blood of tumor patients.
AU - Schwarzenbach, Heidi
PY - 2012
Y1 - 2012
N2 - Carcinogenesis is accompanied by deregulated tumor cell death and changes in proliferative processes. Apoptotic cells release different components, such as nucleosomes and caspases, into the blood circulation that can be detected by minimally invasive assays. Caspases belong to a large family of proteases, which are frequently overexpressed in various cancer entities and involved in metastases. One critical event of tumor invasion that signals the initiation of the metastatic cascade is the degradation of basement membrane components by protease supporting invasive cell migration and the dissemination of tumor cells.
AB - Carcinogenesis is accompanied by deregulated tumor cell death and changes in proliferative processes. Apoptotic cells release different components, such as nucleosomes and caspases, into the blood circulation that can be detected by minimally invasive assays. Caspases belong to a large family of proteases, which are frequently overexpressed in various cancer entities and involved in metastases. One critical event of tumor invasion that signals the initiation of the metastatic cascade is the degradation of basement membrane components by protease supporting invasive cell migration and the dissemination of tumor cells.
KW - Humans
KW - Disease Progression
KW - Neoplasm Metastasis
KW - Nucleic Acids/blood
KW - Caspases/metabolism
KW - Peptide Hydrolases/metabolism
KW - DNA/blood
KW - Neoplasms/blood/enzymology/pathology
KW - Humans
KW - Disease Progression
KW - Neoplasm Metastasis
KW - Nucleic Acids/blood
KW - Caspases/metabolism
KW - Peptide Hydrolases/metabolism
KW - DNA/blood
KW - Neoplasms/blood/enzymology/pathology
M3 - SCORING: Journal article
VL - 12 Suppl 1
SP - 163
EP - 169
JO - EXPERT OPIN BIOL TH
JF - EXPERT OPIN BIOL TH
SN - 1471-2598
ER -