Circulating nucleic acids and protease activities in blood of tumor patients.

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Circulating nucleic acids and protease activities in blood of tumor patients. / Schwarzenbach, Heidi.

in: EXPERT OPIN BIOL TH, Jahrgang 12 Suppl 1, 2012, S. 163-169.

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@article{1c454fd401b44ec88396972bc8cc7610,
title = "Circulating nucleic acids and protease activities in blood of tumor patients.",
abstract = "Carcinogenesis is accompanied by deregulated tumor cell death and changes in proliferative processes. Apoptotic cells release different components, such as nucleosomes and caspases, into the blood circulation that can be detected by minimally invasive assays. Caspases belong to a large family of proteases, which are frequently overexpressed in various cancer entities and involved in metastases. One critical event of tumor invasion that signals the initiation of the metastatic cascade is the degradation of basement membrane components by protease supporting invasive cell migration and the dissemination of tumor cells.",
keywords = "Humans, Disease Progression, Neoplasm Metastasis, Nucleic Acids/*blood, Caspases/metabolism, Peptide Hydrolases/*metabolism, DNA/blood, Neoplasms/*blood/enzymology/pathology, Humans, Disease Progression, Neoplasm Metastasis, Nucleic Acids/*blood, Caspases/metabolism, Peptide Hydrolases/*metabolism, DNA/blood, Neoplasms/*blood/enzymology/pathology",
author = "Heidi Schwarzenbach",
year = "2012",
language = "English",
volume = "12 Suppl 1",
pages = "163--169",
journal = "EXPERT OPIN BIOL TH",
issn = "1471-2598",
publisher = "informa healthcare",

}

RIS

TY - JOUR

T1 - Circulating nucleic acids and protease activities in blood of tumor patients.

AU - Schwarzenbach, Heidi

PY - 2012

Y1 - 2012

N2 - Carcinogenesis is accompanied by deregulated tumor cell death and changes in proliferative processes. Apoptotic cells release different components, such as nucleosomes and caspases, into the blood circulation that can be detected by minimally invasive assays. Caspases belong to a large family of proteases, which are frequently overexpressed in various cancer entities and involved in metastases. One critical event of tumor invasion that signals the initiation of the metastatic cascade is the degradation of basement membrane components by protease supporting invasive cell migration and the dissemination of tumor cells.

AB - Carcinogenesis is accompanied by deregulated tumor cell death and changes in proliferative processes. Apoptotic cells release different components, such as nucleosomes and caspases, into the blood circulation that can be detected by minimally invasive assays. Caspases belong to a large family of proteases, which are frequently overexpressed in various cancer entities and involved in metastases. One critical event of tumor invasion that signals the initiation of the metastatic cascade is the degradation of basement membrane components by protease supporting invasive cell migration and the dissemination of tumor cells.

KW - Humans

KW - Disease Progression

KW - Neoplasm Metastasis

KW - Nucleic Acids/blood

KW - Caspases/metabolism

KW - Peptide Hydrolases/metabolism

KW - DNA/blood

KW - Neoplasms/blood/enzymology/pathology

KW - Humans

KW - Disease Progression

KW - Neoplasm Metastasis

KW - Nucleic Acids/blood

KW - Caspases/metabolism

KW - Peptide Hydrolases/metabolism

KW - DNA/blood

KW - Neoplasms/blood/enzymology/pathology

M3 - SCORING: Journal article

VL - 12 Suppl 1

SP - 163

EP - 169

JO - EXPERT OPIN BIOL TH

JF - EXPERT OPIN BIOL TH

SN - 1471-2598

ER -