Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex
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Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex. / Narayanan, Ramanathan; Pham, Linh; Kerimoglu, Cemil; Watanabe, Takashi; Castro Hernandez, Ricardo; Sokpor, Godwin; Ulmke, Pauline Antonie; Kiszka, Kamila A; Tonchev, Anton B; Rosenbusch, Joachim; Seong, Rho H; Teichmann, Ulrike; Frahm, Jens; Fischer, Andre; Bonn, Stefan; Stoykova, Anastassia; Staiger, Jochen F; Tuoc, Tran.
In: ISCIENCE, Vol. 4, 29.06.2018, p. 109-126.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex
AU - Narayanan, Ramanathan
AU - Pham, Linh
AU - Kerimoglu, Cemil
AU - Watanabe, Takashi
AU - Castro Hernandez, Ricardo
AU - Sokpor, Godwin
AU - Ulmke, Pauline Antonie
AU - Kiszka, Kamila A
AU - Tonchev, Anton B
AU - Rosenbusch, Joachim
AU - Seong, Rho H
AU - Teichmann, Ulrike
AU - Frahm, Jens
AU - Fischer, Andre
AU - Bonn, Stefan
AU - Stoykova, Anastassia
AU - Staiger, Jochen F
AU - Tuoc, Tran
N1 - Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.
PY - 2018/6/29
Y1 - 2018/6/29
N2 - The abundance of basal progenitors (BPs), basal radial glia progenitors (bRGs) and basal intermediate progenitors (bIPs), in primate brain has been correlated to the high degree of cortical folding. Here we examined the role of BAF155, a subunit of the chromatin remodeling BAF complex, in generation of cortical progenitor heterogeneity. The conditional deletion of BAF155 led to diminished bIP pool and increased number of bRGs, due to delamination of apical RGs. We found that BAF155 is required for normal activity of neurogenic transcription factor PAX6, thus controlling the expression of genes that are involved in bIP specification, cell-cell interaction, and establishment of adherens junction. In a PAX6-dependent manner, BAF155 regulates the expression of the CDC42 effector protein CEP4, thereby controlling progenitor delamination. Furthermore, BAF155-dependent chromatin remodeling seems to exert a specific role in the genesis of BPs through the regulation of human RG-specific genes (such as Foxn4) that possibly acquired evolutionary significance.
AB - The abundance of basal progenitors (BPs), basal radial glia progenitors (bRGs) and basal intermediate progenitors (bIPs), in primate brain has been correlated to the high degree of cortical folding. Here we examined the role of BAF155, a subunit of the chromatin remodeling BAF complex, in generation of cortical progenitor heterogeneity. The conditional deletion of BAF155 led to diminished bIP pool and increased number of bRGs, due to delamination of apical RGs. We found that BAF155 is required for normal activity of neurogenic transcription factor PAX6, thus controlling the expression of genes that are involved in bIP specification, cell-cell interaction, and establishment of adherens junction. In a PAX6-dependent manner, BAF155 regulates the expression of the CDC42 effector protein CEP4, thereby controlling progenitor delamination. Furthermore, BAF155-dependent chromatin remodeling seems to exert a specific role in the genesis of BPs through the regulation of human RG-specific genes (such as Foxn4) that possibly acquired evolutionary significance.
KW - Journal Article
U2 - 10.1016/j.isci.2018.05.014
DO - 10.1016/j.isci.2018.05.014
M3 - SCORING: Journal article
C2 - 30240734
VL - 4
SP - 109
EP - 126
JO - ISCIENCE
JF - ISCIENCE
SN - 2589-0042
ER -