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Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex

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Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex. / Narayanan, Ramanathan; Pham, Linh; Kerimoglu, Cemil; Watanabe, Takashi; Castro Hernandez, Ricardo; Sokpor, Godwin; Ulmke, Pauline Antonie; Kiszka, Kamila A; Tonchev, Anton B; Rosenbusch, Joachim; Seong, Rho H; Teichmann, Ulrike; Frahm, Jens; Fischer, Andre; Bonn, Stefan; Stoykova, Anastassia; Staiger, Jochen F; Tuoc, Tran.

in: ISCIENCE, Jahrgang 4, 29.06.2018, S. 109-126.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Narayanan, R, Pham, L, Kerimoglu, C, Watanabe, T, Castro Hernandez, R, Sokpor, G, Ulmke, PA, Kiszka, KA, Tonchev, AB, Rosenbusch, J, Seong, RH, Teichmann, U, Frahm, J, Fischer, A, Bonn, S, Stoykova, A, Staiger, JF & Tuoc, T 2018, 'Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex', ISCIENCE, Jg. 4, S. 109-126. https://doi.org/10.1016/j.isci.2018.05.014

APA

Narayanan, R., Pham, L., Kerimoglu, C., Watanabe, T., Castro Hernandez, R., Sokpor, G., Ulmke, P. A., Kiszka, K. A., Tonchev, A. B., Rosenbusch, J., Seong, R. H., Teichmann, U., Frahm, J., Fischer, A., Bonn, S., Stoykova, A., Staiger, J. F., & Tuoc, T. (2018). Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex. ISCIENCE, 4, 109-126. https://doi.org/10.1016/j.isci.2018.05.014

Vancouver

Narayanan R, Pham L, Kerimoglu C, Watanabe T, Castro Hernandez R, Sokpor G et al. Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex. ISCIENCE. 2018 Jun 29;4:109-126. https://doi.org/10.1016/j.isci.2018.05.014

Bibtex

@article{1cdfa0b620974027beec2a24e1474f5a,
title = "Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex",
abstract = "The abundance of basal progenitors (BPs), basal radial glia progenitors (bRGs) and basal intermediate progenitors (bIPs), in primate brain has been correlated to the high degree of cortical folding. Here we examined the role of BAF155, a subunit of the chromatin remodeling BAF complex, in generation of cortical progenitor heterogeneity. The conditional deletion of BAF155 led to diminished bIP pool and increased number of bRGs, due to delamination of apical RGs. We found that BAF155 is required for normal activity of neurogenic transcription factor PAX6, thus controlling the expression of genes that are involved in bIP specification, cell-cell interaction, and establishment of adherens junction. In a PAX6-dependent manner, BAF155 regulates the expression of the CDC42 effector protein CEP4, thereby controlling progenitor delamination. Furthermore, BAF155-dependent chromatin remodeling seems to exert a specific role in the genesis of BPs through the regulation of human RG-specific genes (such as Foxn4) that possibly acquired evolutionary significance.",
keywords = "Journal Article",
author = "Ramanathan Narayanan and Linh Pham and Cemil Kerimoglu and Takashi Watanabe and {Castro Hernandez}, Ricardo and Godwin Sokpor and Ulmke, {Pauline Antonie} and Kiszka, {Kamila A} and Tonchev, {Anton B} and Joachim Rosenbusch and Seong, {Rho H} and Ulrike Teichmann and Jens Frahm and Andre Fischer and Stefan Bonn and Anastassia Stoykova and Staiger, {Jochen F} and Tran Tuoc",
note = "Copyright {\textcopyright} 2018 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2018",
month = jun,
day = "29",
doi = "10.1016/j.isci.2018.05.014",
language = "English",
volume = "4",
pages = "109--126",
journal = "ISCIENCE",
issn = "2589-0042",
publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex

AU - Narayanan, Ramanathan

AU - Pham, Linh

AU - Kerimoglu, Cemil

AU - Watanabe, Takashi

AU - Castro Hernandez, Ricardo

AU - Sokpor, Godwin

AU - Ulmke, Pauline Antonie

AU - Kiszka, Kamila A

AU - Tonchev, Anton B

AU - Rosenbusch, Joachim

AU - Seong, Rho H

AU - Teichmann, Ulrike

AU - Frahm, Jens

AU - Fischer, Andre

AU - Bonn, Stefan

AU - Stoykova, Anastassia

AU - Staiger, Jochen F

AU - Tuoc, Tran

N1 - Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2018/6/29

Y1 - 2018/6/29

N2 - The abundance of basal progenitors (BPs), basal radial glia progenitors (bRGs) and basal intermediate progenitors (bIPs), in primate brain has been correlated to the high degree of cortical folding. Here we examined the role of BAF155, a subunit of the chromatin remodeling BAF complex, in generation of cortical progenitor heterogeneity. The conditional deletion of BAF155 led to diminished bIP pool and increased number of bRGs, due to delamination of apical RGs. We found that BAF155 is required for normal activity of neurogenic transcription factor PAX6, thus controlling the expression of genes that are involved in bIP specification, cell-cell interaction, and establishment of adherens junction. In a PAX6-dependent manner, BAF155 regulates the expression of the CDC42 effector protein CEP4, thereby controlling progenitor delamination. Furthermore, BAF155-dependent chromatin remodeling seems to exert a specific role in the genesis of BPs through the regulation of human RG-specific genes (such as Foxn4) that possibly acquired evolutionary significance.

AB - The abundance of basal progenitors (BPs), basal radial glia progenitors (bRGs) and basal intermediate progenitors (bIPs), in primate brain has been correlated to the high degree of cortical folding. Here we examined the role of BAF155, a subunit of the chromatin remodeling BAF complex, in generation of cortical progenitor heterogeneity. The conditional deletion of BAF155 led to diminished bIP pool and increased number of bRGs, due to delamination of apical RGs. We found that BAF155 is required for normal activity of neurogenic transcription factor PAX6, thus controlling the expression of genes that are involved in bIP specification, cell-cell interaction, and establishment of adherens junction. In a PAX6-dependent manner, BAF155 regulates the expression of the CDC42 effector protein CEP4, thereby controlling progenitor delamination. Furthermore, BAF155-dependent chromatin remodeling seems to exert a specific role in the genesis of BPs through the regulation of human RG-specific genes (such as Foxn4) that possibly acquired evolutionary significance.

KW - Journal Article

U2 - 10.1016/j.isci.2018.05.014

DO - 10.1016/j.isci.2018.05.014

M3 - SCORING: Journal article

C2 - 30240734

VL - 4

SP - 109

EP - 126

JO - ISCIENCE

JF - ISCIENCE

SN - 2589-0042

ER -