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Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis

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Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis. / Grupp, Katharina; Bonk, Sarah; Poppe, Annika; Wodack, Karin; Reeh, Matthias; Gocht, Andreas; Mann, Oliver; Izbicki, Jakob R; Bachmann, Kai.

In: ASIAN J SURG, Vol. 43, No. 1, 01.2020, p. 272-277.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Grupp, K, Bonk, S, Poppe, A, Wodack, K, Reeh, M, Gocht, A, Mann, O, Izbicki, JR & Bachmann, K 2020, 'Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis', ASIAN J SURG, vol. 43, no. 1, pp. 272-277. https://doi.org/10.1016/j.asjsur.2019.05.002

APA

Grupp, K., Bonk, S., Poppe, A., Wodack, K., Reeh, M., Gocht, A., Mann, O., Izbicki, J. R., & Bachmann, K. (2020). Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis. ASIAN J SURG, 43(1), 272-277. https://doi.org/10.1016/j.asjsur.2019.05.002

Vancouver

Grupp K, Bonk S, Poppe A, Wodack K, Reeh M, Gocht A et al. Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis. ASIAN J SURG. 2020 Jan;43(1):272-277. https://doi.org/10.1016/j.asjsur.2019.05.002

Bibtex

@article{dab01a2fbd344ab9950acbb7c894ed28,
title = "Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis",
abstract = "BACKGROUND: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model.METHODS: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, 'Porcine Well-being' (PWB) and fitness score and post-mortal histopathological data were analysed.RESULTS: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019).CONCLUSIONS: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs.",
author = "Katharina Grupp and Sarah Bonk and Annika Poppe and Karin Wodack and Matthias Reeh and Andreas Gocht and Oliver Mann and Izbicki, {Jakob R} and Kai Bachmann",
note = "Copyright {\textcopyright} 2019. Published by Elsevier Taiwan LLC.",
year = "2020",
month = jan,
doi = "10.1016/j.asjsur.2019.05.002",
language = "English",
volume = "43",
pages = "272--277",
journal = "ASIAN J SURG",
issn = "1015-9584",
publisher = "Elsevier Taiwan LLC",
number = "1",

}

RIS

TY - JOUR

T1 - Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis

AU - Grupp, Katharina

AU - Bonk, Sarah

AU - Poppe, Annika

AU - Wodack, Karin

AU - Reeh, Matthias

AU - Gocht, Andreas

AU - Mann, Oliver

AU - Izbicki, Jakob R

AU - Bachmann, Kai

N1 - Copyright © 2019. Published by Elsevier Taiwan LLC.

PY - 2020/1

Y1 - 2020/1

N2 - BACKGROUND: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model.METHODS: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, 'Porcine Well-being' (PWB) and fitness score and post-mortal histopathological data were analysed.RESULTS: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019).CONCLUSIONS: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs.

AB - BACKGROUND: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model.METHODS: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, 'Porcine Well-being' (PWB) and fitness score and post-mortal histopathological data were analysed.RESULTS: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019).CONCLUSIONS: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs.

U2 - 10.1016/j.asjsur.2019.05.002

DO - 10.1016/j.asjsur.2019.05.002

M3 - SCORING: Journal article

C2 - 31171354

VL - 43

SP - 272

EP - 277

JO - ASIAN J SURG

JF - ASIAN J SURG

SN - 1015-9584

IS - 1

ER -