Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis
Standard
Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis. / Grupp, Katharina; Bonk, Sarah; Poppe, Annika; Wodack, Karin; Reeh, Matthias; Gocht, Andreas; Mann, Oliver; Izbicki, Jakob R; Bachmann, Kai.
in: ASIAN J SURG, Jahrgang 43, Nr. 1, 01.2020, S. 272-277.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis
AU - Grupp, Katharina
AU - Bonk, Sarah
AU - Poppe, Annika
AU - Wodack, Karin
AU - Reeh, Matthias
AU - Gocht, Andreas
AU - Mann, Oliver
AU - Izbicki, Jakob R
AU - Bachmann, Kai
N1 - Copyright © 2019. Published by Elsevier Taiwan LLC.
PY - 2020/1
Y1 - 2020/1
N2 - BACKGROUND: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model.METHODS: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, 'Porcine Well-being' (PWB) and fitness score and post-mortal histopathological data were analysed.RESULTS: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019).CONCLUSIONS: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs.
AB - BACKGROUND: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model.METHODS: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, 'Porcine Well-being' (PWB) and fitness score and post-mortal histopathological data were analysed.RESULTS: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019).CONCLUSIONS: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs.
U2 - 10.1016/j.asjsur.2019.05.002
DO - 10.1016/j.asjsur.2019.05.002
M3 - SCORING: Journal article
C2 - 31171354
VL - 43
SP - 272
EP - 277
JO - ASIAN J SURG
JF - ASIAN J SURG
SN - 1015-9584
IS - 1
ER -