Chloride accumulation in endosomes and lysosomes: facts checked in mice
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Chloride accumulation in endosomes and lysosomes: facts checked in mice. / Schwappach, Blanche.
In: EMBO J, Vol. 39, No. 9, 04.05.2020, p. e104812.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Chloride accumulation in endosomes and lysosomes: facts checked in mice
AU - Schwappach, Blanche
N1 - © 2020 The Author.
PY - 2020/5/4
Y1 - 2020/5/4
N2 - Loss of the ClC-3 chloride/proton exchanger found in intracellular compartments leads to marked neurodegeneration. New genetic work by Weinert et al (2020) now shows that selective impairment of ClC-3's ion exchange activity is sufficient to elicit this severe phenotype in vivo. ClC-3 cooperates with the closely related ClC-4 in protecting endolysosomal chloride balance and neuronal integrity.
AB - Loss of the ClC-3 chloride/proton exchanger found in intracellular compartments leads to marked neurodegeneration. New genetic work by Weinert et al (2020) now shows that selective impairment of ClC-3's ion exchange activity is sufficient to elicit this severe phenotype in vivo. ClC-3 cooperates with the closely related ClC-4 in protecting endolysosomal chloride balance and neuronal integrity.
U2 - 10.15252/embj.2020104812
DO - 10.15252/embj.2020104812
M3 - SCORING: Journal article
C2 - 32270512
VL - 39
SP - e104812
JO - EMBO J
JF - EMBO J
SN - 0261-4189
IS - 9
ER -