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Characterization of animal models for primary sclerosing cholangitis (PSC)

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Characterization of animal models for primary sclerosing cholangitis (PSC). / Fickert, Peter; Pollheimer, Marion J; Beuers, Ulrich; Lackner, Carolin; Hirschfield, Gideon; Housset, Chantal; Keitel, Verena; Schramm, Christoph; Marschall, Hanns-Ulrich; Karlsen, Tom H; Melum, Espen; Kaser, Arthur; Eksteen, Bertus; Strazzabosco, Mario; Manns, Michael; Trauner, Michael; International PSC Study Group (IPSCSG).

In: J HEPATOL, Vol. 60, No. 6, 01.06.2014, p. 1290-1303.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fickert, P, Pollheimer, MJ, Beuers, U, Lackner, C, Hirschfield, G, Housset, C, Keitel, V, Schramm, C, Marschall, H-U, Karlsen, TH, Melum, E, Kaser, A, Eksteen, B, Strazzabosco, M, Manns, M, Trauner, M & International PSC Study Group (IPSCSG) 2014, 'Characterization of animal models for primary sclerosing cholangitis (PSC)', J HEPATOL, vol. 60, no. 6, pp. 1290-1303. https://doi.org/10.1016/j.jhep.2014.02.006

APA

Fickert, P., Pollheimer, M. J., Beuers, U., Lackner, C., Hirschfield, G., Housset, C., Keitel, V., Schramm, C., Marschall, H-U., Karlsen, T. H., Melum, E., Kaser, A., Eksteen, B., Strazzabosco, M., Manns, M., Trauner, M., & International PSC Study Group (IPSCSG) (2014). Characterization of animal models for primary sclerosing cholangitis (PSC). J HEPATOL, 60(6), 1290-1303. https://doi.org/10.1016/j.jhep.2014.02.006

Vancouver

Fickert P, Pollheimer MJ, Beuers U, Lackner C, Hirschfield G, Housset C et al. Characterization of animal models for primary sclerosing cholangitis (PSC). J HEPATOL. 2014 Jun 1;60(6):1290-1303. https://doi.org/10.1016/j.jhep.2014.02.006

Bibtex

@article{711f73ba68fc4e61bcb12d9efcaaef8e,
title = "Characterization of animal models for primary sclerosing cholangitis (PSC)",
abstract = "Primary sclerosing cholangitis (PSC) is a chronic cholangiopathy characterized by biliary fibrosis, development of cholestasis and end stage liver disease, high risk of malignancy, and frequent need for liver transplantation. The poor understanding of its pathogenesis is also reflected in the lack of effective medical treatment. Well-characterized animal models are utterly needed to develop novel pathogenetic concepts and study new treatment strategies. Currently there is no consensus on how to evaluate and characterize potential PSC models, which makes direct comparison of experimental results and effective exchange of study material between research groups difficult. The International Primary Sclerosing Cholangitis Study Group (IPSCSG) has therefore summarized these key issues in a position paper proposing standard requirements for the study of animal models of PSC.",
keywords = "Animals, Cholangitis, Sclerosing, Disease Models, Animal, Humans",
author = "Peter Fickert and Pollheimer, {Marion J} and Ulrich Beuers and Carolin Lackner and Gideon Hirschfield and Chantal Housset and Verena Keitel and Christoph Schramm and Hanns-Ulrich Marschall and Karlsen, {Tom H} and Espen Melum and Arthur Kaser and Bertus Eksteen and Mario Strazzabosco and Michael Manns and Michael Trauner and {International PSC Study Group (IPSCSG)}",
note = "Copyright {\textcopyright} 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.",
year = "2014",
month = jun,
day = "1",
doi = "10.1016/j.jhep.2014.02.006",
language = "English",
volume = "60",
pages = "1290--1303",
journal = "J HEPATOL",
issn = "0168-8278",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Characterization of animal models for primary sclerosing cholangitis (PSC)

AU - Fickert, Peter

AU - Pollheimer, Marion J

AU - Beuers, Ulrich

AU - Lackner, Carolin

AU - Hirschfield, Gideon

AU - Housset, Chantal

AU - Keitel, Verena

AU - Schramm, Christoph

AU - Marschall, Hanns-Ulrich

AU - Karlsen, Tom H

AU - Melum, Espen

AU - Kaser, Arthur

AU - Eksteen, Bertus

AU - Strazzabosco, Mario

AU - Manns, Michael

AU - Trauner, Michael

AU - International PSC Study Group (IPSCSG)

N1 - Copyright © 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

PY - 2014/6/1

Y1 - 2014/6/1

N2 - Primary sclerosing cholangitis (PSC) is a chronic cholangiopathy characterized by biliary fibrosis, development of cholestasis and end stage liver disease, high risk of malignancy, and frequent need for liver transplantation. The poor understanding of its pathogenesis is also reflected in the lack of effective medical treatment. Well-characterized animal models are utterly needed to develop novel pathogenetic concepts and study new treatment strategies. Currently there is no consensus on how to evaluate and characterize potential PSC models, which makes direct comparison of experimental results and effective exchange of study material between research groups difficult. The International Primary Sclerosing Cholangitis Study Group (IPSCSG) has therefore summarized these key issues in a position paper proposing standard requirements for the study of animal models of PSC.

AB - Primary sclerosing cholangitis (PSC) is a chronic cholangiopathy characterized by biliary fibrosis, development of cholestasis and end stage liver disease, high risk of malignancy, and frequent need for liver transplantation. The poor understanding of its pathogenesis is also reflected in the lack of effective medical treatment. Well-characterized animal models are utterly needed to develop novel pathogenetic concepts and study new treatment strategies. Currently there is no consensus on how to evaluate and characterize potential PSC models, which makes direct comparison of experimental results and effective exchange of study material between research groups difficult. The International Primary Sclerosing Cholangitis Study Group (IPSCSG) has therefore summarized these key issues in a position paper proposing standard requirements for the study of animal models of PSC.

KW - Animals

KW - Cholangitis, Sclerosing

KW - Disease Models, Animal

KW - Humans

U2 - 10.1016/j.jhep.2014.02.006

DO - 10.1016/j.jhep.2014.02.006

M3 - SCORING: Journal article

C2 - 24560657

VL - 60

SP - 1290

EP - 1303

JO - J HEPATOL

JF - J HEPATOL

SN - 0168-8278

IS - 6

ER -