Characterization of animal models for primary sclerosing cholangitis (PSC)
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Characterization of animal models for primary sclerosing cholangitis (PSC). / Fickert, Peter; Pollheimer, Marion J; Beuers, Ulrich; Lackner, Carolin; Hirschfield, Gideon; Housset, Chantal; Keitel, Verena; Schramm, Christoph; Marschall, Hanns-Ulrich; Karlsen, Tom H; Melum, Espen; Kaser, Arthur; Eksteen, Bertus; Strazzabosco, Mario; Manns, Michael; Trauner, Michael; International PSC Study Group (IPSCSG).
in: J HEPATOL, Jahrgang 60, Nr. 6, 01.06.2014, S. 1290-1303.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Characterization of animal models for primary sclerosing cholangitis (PSC)
AU - Fickert, Peter
AU - Pollheimer, Marion J
AU - Beuers, Ulrich
AU - Lackner, Carolin
AU - Hirschfield, Gideon
AU - Housset, Chantal
AU - Keitel, Verena
AU - Schramm, Christoph
AU - Marschall, Hanns-Ulrich
AU - Karlsen, Tom H
AU - Melum, Espen
AU - Kaser, Arthur
AU - Eksteen, Bertus
AU - Strazzabosco, Mario
AU - Manns, Michael
AU - Trauner, Michael
AU - International PSC Study Group (IPSCSG)
N1 - Copyright © 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
PY - 2014/6/1
Y1 - 2014/6/1
N2 - Primary sclerosing cholangitis (PSC) is a chronic cholangiopathy characterized by biliary fibrosis, development of cholestasis and end stage liver disease, high risk of malignancy, and frequent need for liver transplantation. The poor understanding of its pathogenesis is also reflected in the lack of effective medical treatment. Well-characterized animal models are utterly needed to develop novel pathogenetic concepts and study new treatment strategies. Currently there is no consensus on how to evaluate and characterize potential PSC models, which makes direct comparison of experimental results and effective exchange of study material between research groups difficult. The International Primary Sclerosing Cholangitis Study Group (IPSCSG) has therefore summarized these key issues in a position paper proposing standard requirements for the study of animal models of PSC.
AB - Primary sclerosing cholangitis (PSC) is a chronic cholangiopathy characterized by biliary fibrosis, development of cholestasis and end stage liver disease, high risk of malignancy, and frequent need for liver transplantation. The poor understanding of its pathogenesis is also reflected in the lack of effective medical treatment. Well-characterized animal models are utterly needed to develop novel pathogenetic concepts and study new treatment strategies. Currently there is no consensus on how to evaluate and characterize potential PSC models, which makes direct comparison of experimental results and effective exchange of study material between research groups difficult. The International Primary Sclerosing Cholangitis Study Group (IPSCSG) has therefore summarized these key issues in a position paper proposing standard requirements for the study of animal models of PSC.
KW - Animals
KW - Cholangitis, Sclerosing
KW - Disease Models, Animal
KW - Humans
U2 - 10.1016/j.jhep.2014.02.006
DO - 10.1016/j.jhep.2014.02.006
M3 - SCORING: Journal article
C2 - 24560657
VL - 60
SP - 1290
EP - 1303
JO - J HEPATOL
JF - J HEPATOL
SN - 0168-8278
IS - 6
ER -