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Changes in liver stiffness using acoustic radiation force impulse imaging in patients with obstructive cholestasis and cholangitis

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Changes in liver stiffness using acoustic radiation force impulse imaging in patients with obstructive cholestasis and cholangitis. / Attia, Dina; Pischke, Sven; Negm, Ahmad A; Rifai, Kinan; Manns, Michael P; Gebel, Michael J; Lankisch, Tim O; Potthoff, Andrej.

In: DIGEST LIVER DIS, Vol. 46, No. 7, 01.07.2014, p. 625-631.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Attia, D, Pischke, S, Negm, AA, Rifai, K, Manns, MP, Gebel, MJ, Lankisch, TO & Potthoff, A 2014, 'Changes in liver stiffness using acoustic radiation force impulse imaging in patients with obstructive cholestasis and cholangitis', DIGEST LIVER DIS, vol. 46, no. 7, pp. 625-631. https://doi.org/10.1016/j.dld.2014.02.020

APA

Attia, D., Pischke, S., Negm, A. A., Rifai, K., Manns, M. P., Gebel, M. J., Lankisch, T. O., & Potthoff, A. (2014). Changes in liver stiffness using acoustic radiation force impulse imaging in patients with obstructive cholestasis and cholangitis. DIGEST LIVER DIS, 46(7), 625-631. https://doi.org/10.1016/j.dld.2014.02.020

Vancouver

Attia D, Pischke S, Negm AA, Rifai K, Manns MP, Gebel MJ et al. Changes in liver stiffness using acoustic radiation force impulse imaging in patients with obstructive cholestasis and cholangitis. DIGEST LIVER DIS. 2014 Jul 1;46(7):625-631. https://doi.org/10.1016/j.dld.2014.02.020

Bibtex

@article{0ce976e92093455f9ff500769475d010,
title = "Changes in liver stiffness using acoustic radiation force impulse imaging in patients with obstructive cholestasis and cholangitis",
abstract = "BACKGROUND: Acoustic radiation force impulse imaging is used to assess stages of liver fibrosis. The aim of our study was to evaluate liver stiffness changes in patients with biliary obstruction with or without sclerosing cholangitis after biliary drainage.METHODS: A total of 71 patients were enrolled in this prospective study (cohort N=51, control group N=20); 51 patients with obstructive cholestasis, indicated for endoscopic retrograde cholangiography, received stiffness measurement by acoustic radiation force impulse imaging before and 1-2 days after endoscopic retrograde cholangiography. Seventeen patients with obstructive cholestasis had primary or secondary sclerosing cholangitis. Forty one patients had a follow-up acoustic radiation force impulse imaging measurement after 3.0 ± 9.31 weeks.RESULTS: In all patients with obstructive cholestasis, stiffness decreased significantly after biliary drainage (p<0.001). The main decrease was observed within 2 days after endoscopic retrograde cholangiography (1.92-1.57 m/s, p<0.001) and correlated with the decrease of bilirubin and alkaline phosphatase (p=0.04 and p=0.002, respectively). In patients with sclerosing cholangitis, the initial decrease of stiffness after biliary drainage was weaker than in those without (2.1-1.85 m/s vs. 1.81-1.43 m/s, p=0.016).CONCLUSION: Acoustic radiation force impulse imaging elastography shows that liver stiffness is increased by biliary obstruction, and decreases after endoscopic retrograde cholangiography irrespective of the aetiology. In patients with sclerosing cholangitis the reduction in stiffness after biliary drainage is impaired.",
keywords = "Adult, Aged, Alkaline Phosphatase, Bilirubin, Cholangiopancreatography, Endoscopic Retrograde, Cholangitis, Sclerosing, Cholestasis, Drainage, Elasticity, Elasticity Imaging Techniques, Female, Humans, Liver, Male, Middle Aged, Prospective Studies",
author = "Dina Attia and Sven Pischke and Negm, {Ahmad A} and Kinan Rifai and Manns, {Michael P} and Gebel, {Michael J} and Lankisch, {Tim O} and Andrej Potthoff",
note = "Copyright {\textcopyright} 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.",
year = "2014",
month = jul,
day = "1",
doi = "10.1016/j.dld.2014.02.020",
language = "English",
volume = "46",
pages = "625--631",
journal = "DIGEST LIVER DIS",
issn = "1590-8658",
publisher = "Elsevier",
number = "7",

}

RIS

TY - JOUR

T1 - Changes in liver stiffness using acoustic radiation force impulse imaging in patients with obstructive cholestasis and cholangitis

AU - Attia, Dina

AU - Pischke, Sven

AU - Negm, Ahmad A

AU - Rifai, Kinan

AU - Manns, Michael P

AU - Gebel, Michael J

AU - Lankisch, Tim O

AU - Potthoff, Andrej

N1 - Copyright © 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

PY - 2014/7/1

Y1 - 2014/7/1

N2 - BACKGROUND: Acoustic radiation force impulse imaging is used to assess stages of liver fibrosis. The aim of our study was to evaluate liver stiffness changes in patients with biliary obstruction with or without sclerosing cholangitis after biliary drainage.METHODS: A total of 71 patients were enrolled in this prospective study (cohort N=51, control group N=20); 51 patients with obstructive cholestasis, indicated for endoscopic retrograde cholangiography, received stiffness measurement by acoustic radiation force impulse imaging before and 1-2 days after endoscopic retrograde cholangiography. Seventeen patients with obstructive cholestasis had primary or secondary sclerosing cholangitis. Forty one patients had a follow-up acoustic radiation force impulse imaging measurement after 3.0 ± 9.31 weeks.RESULTS: In all patients with obstructive cholestasis, stiffness decreased significantly after biliary drainage (p<0.001). The main decrease was observed within 2 days after endoscopic retrograde cholangiography (1.92-1.57 m/s, p<0.001) and correlated with the decrease of bilirubin and alkaline phosphatase (p=0.04 and p=0.002, respectively). In patients with sclerosing cholangitis, the initial decrease of stiffness after biliary drainage was weaker than in those without (2.1-1.85 m/s vs. 1.81-1.43 m/s, p=0.016).CONCLUSION: Acoustic radiation force impulse imaging elastography shows that liver stiffness is increased by biliary obstruction, and decreases after endoscopic retrograde cholangiography irrespective of the aetiology. In patients with sclerosing cholangitis the reduction in stiffness after biliary drainage is impaired.

AB - BACKGROUND: Acoustic radiation force impulse imaging is used to assess stages of liver fibrosis. The aim of our study was to evaluate liver stiffness changes in patients with biliary obstruction with or without sclerosing cholangitis after biliary drainage.METHODS: A total of 71 patients were enrolled in this prospective study (cohort N=51, control group N=20); 51 patients with obstructive cholestasis, indicated for endoscopic retrograde cholangiography, received stiffness measurement by acoustic radiation force impulse imaging before and 1-2 days after endoscopic retrograde cholangiography. Seventeen patients with obstructive cholestasis had primary or secondary sclerosing cholangitis. Forty one patients had a follow-up acoustic radiation force impulse imaging measurement after 3.0 ± 9.31 weeks.RESULTS: In all patients with obstructive cholestasis, stiffness decreased significantly after biliary drainage (p<0.001). The main decrease was observed within 2 days after endoscopic retrograde cholangiography (1.92-1.57 m/s, p<0.001) and correlated with the decrease of bilirubin and alkaline phosphatase (p=0.04 and p=0.002, respectively). In patients with sclerosing cholangitis, the initial decrease of stiffness after biliary drainage was weaker than in those without (2.1-1.85 m/s vs. 1.81-1.43 m/s, p=0.016).CONCLUSION: Acoustic radiation force impulse imaging elastography shows that liver stiffness is increased by biliary obstruction, and decreases after endoscopic retrograde cholangiography irrespective of the aetiology. In patients with sclerosing cholangitis the reduction in stiffness after biliary drainage is impaired.

KW - Adult

KW - Aged

KW - Alkaline Phosphatase

KW - Bilirubin

KW - Cholangiopancreatography, Endoscopic Retrograde

KW - Cholangitis, Sclerosing

KW - Cholestasis

KW - Drainage

KW - Elasticity

KW - Elasticity Imaging Techniques

KW - Female

KW - Humans

KW - Liver

KW - Male

KW - Middle Aged

KW - Prospective Studies

U2 - 10.1016/j.dld.2014.02.020

DO - 10.1016/j.dld.2014.02.020

M3 - SCORING: Journal article

C2 - 24666759

VL - 46

SP - 625

EP - 631

JO - DIGEST LIVER DIS

JF - DIGEST LIVER DIS

SN - 1590-8658

IS - 7

ER -