Changes in liver stiffness using acoustic radiation force impulse imaging in patients with obstructive cholestasis and cholangitis
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Changes in liver stiffness using acoustic radiation force impulse imaging in patients with obstructive cholestasis and cholangitis. / Attia, Dina; Pischke, Sven; Negm, Ahmad A; Rifai, Kinan; Manns, Michael P; Gebel, Michael J; Lankisch, Tim O; Potthoff, Andrej.
in: DIGEST LIVER DIS, Jahrgang 46, Nr. 7, 01.07.2014, S. 625-631.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Changes in liver stiffness using acoustic radiation force impulse imaging in patients with obstructive cholestasis and cholangitis
AU - Attia, Dina
AU - Pischke, Sven
AU - Negm, Ahmad A
AU - Rifai, Kinan
AU - Manns, Michael P
AU - Gebel, Michael J
AU - Lankisch, Tim O
AU - Potthoff, Andrej
N1 - Copyright © 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
PY - 2014/7/1
Y1 - 2014/7/1
N2 - BACKGROUND: Acoustic radiation force impulse imaging is used to assess stages of liver fibrosis. The aim of our study was to evaluate liver stiffness changes in patients with biliary obstruction with or without sclerosing cholangitis after biliary drainage.METHODS: A total of 71 patients were enrolled in this prospective study (cohort N=51, control group N=20); 51 patients with obstructive cholestasis, indicated for endoscopic retrograde cholangiography, received stiffness measurement by acoustic radiation force impulse imaging before and 1-2 days after endoscopic retrograde cholangiography. Seventeen patients with obstructive cholestasis had primary or secondary sclerosing cholangitis. Forty one patients had a follow-up acoustic radiation force impulse imaging measurement after 3.0 ± 9.31 weeks.RESULTS: In all patients with obstructive cholestasis, stiffness decreased significantly after biliary drainage (p<0.001). The main decrease was observed within 2 days after endoscopic retrograde cholangiography (1.92-1.57 m/s, p<0.001) and correlated with the decrease of bilirubin and alkaline phosphatase (p=0.04 and p=0.002, respectively). In patients with sclerosing cholangitis, the initial decrease of stiffness after biliary drainage was weaker than in those without (2.1-1.85 m/s vs. 1.81-1.43 m/s, p=0.016).CONCLUSION: Acoustic radiation force impulse imaging elastography shows that liver stiffness is increased by biliary obstruction, and decreases after endoscopic retrograde cholangiography irrespective of the aetiology. In patients with sclerosing cholangitis the reduction in stiffness after biliary drainage is impaired.
AB - BACKGROUND: Acoustic radiation force impulse imaging is used to assess stages of liver fibrosis. The aim of our study was to evaluate liver stiffness changes in patients with biliary obstruction with or without sclerosing cholangitis after biliary drainage.METHODS: A total of 71 patients were enrolled in this prospective study (cohort N=51, control group N=20); 51 patients with obstructive cholestasis, indicated for endoscopic retrograde cholangiography, received stiffness measurement by acoustic radiation force impulse imaging before and 1-2 days after endoscopic retrograde cholangiography. Seventeen patients with obstructive cholestasis had primary or secondary sclerosing cholangitis. Forty one patients had a follow-up acoustic radiation force impulse imaging measurement after 3.0 ± 9.31 weeks.RESULTS: In all patients with obstructive cholestasis, stiffness decreased significantly after biliary drainage (p<0.001). The main decrease was observed within 2 days after endoscopic retrograde cholangiography (1.92-1.57 m/s, p<0.001) and correlated with the decrease of bilirubin and alkaline phosphatase (p=0.04 and p=0.002, respectively). In patients with sclerosing cholangitis, the initial decrease of stiffness after biliary drainage was weaker than in those without (2.1-1.85 m/s vs. 1.81-1.43 m/s, p=0.016).CONCLUSION: Acoustic radiation force impulse imaging elastography shows that liver stiffness is increased by biliary obstruction, and decreases after endoscopic retrograde cholangiography irrespective of the aetiology. In patients with sclerosing cholangitis the reduction in stiffness after biliary drainage is impaired.
KW - Adult
KW - Aged
KW - Alkaline Phosphatase
KW - Bilirubin
KW - Cholangiopancreatography, Endoscopic Retrograde
KW - Cholangitis, Sclerosing
KW - Cholestasis
KW - Drainage
KW - Elasticity
KW - Elasticity Imaging Techniques
KW - Female
KW - Humans
KW - Liver
KW - Male
KW - Middle Aged
KW - Prospective Studies
U2 - 10.1016/j.dld.2014.02.020
DO - 10.1016/j.dld.2014.02.020
M3 - SCORING: Journal article
C2 - 24666759
VL - 46
SP - 625
EP - 631
JO - DIGEST LIVER DIS
JF - DIGEST LIVER DIS
SN - 1590-8658
IS - 7
ER -