cGMP signalling in cardiomyocyte microdomains
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cGMP signalling in cardiomyocyte microdomains. / Bork, Nadja I; Molina, Cristina E; Nikolaev, Viacheslav O.
In: BIOCHEM SOC T, Vol. 47, No. 5, 31.10.2019, p. 1327-1339.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - cGMP signalling in cardiomyocyte microdomains
AU - Bork, Nadja I
AU - Molina, Cristina E
AU - Nikolaev, Viacheslav O
N1 - © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
PY - 2019/10/31
Y1 - 2019/10/31
N2 - 3',5'-Cyclic guanosine monophosphate (cGMP) is one of the major second messengers critically involved in the regulation of cardiac electrophysiology, hypertrophy, and contractility. Recent molecular and cellular studies have significantly advanced our understanding of the cGMP signalling cascade, its local microdomain-specific regulation and its role in protecting the heart from pathological stress. Here, we summarise recent findings on cardiac cGMP microdomain regulation and discuss their potential clinical significance.
AB - 3',5'-Cyclic guanosine monophosphate (cGMP) is one of the major second messengers critically involved in the regulation of cardiac electrophysiology, hypertrophy, and contractility. Recent molecular and cellular studies have significantly advanced our understanding of the cGMP signalling cascade, its local microdomain-specific regulation and its role in protecting the heart from pathological stress. Here, we summarise recent findings on cardiac cGMP microdomain regulation and discuss their potential clinical significance.
KW - Animals
KW - Cyclic GMP/metabolism
KW - Humans
KW - Myocytes, Cardiac/metabolism
KW - Second Messenger Systems
KW - Signal Transduction
U2 - 10.1042/BST20190225
DO - 10.1042/BST20190225
M3 - SCORING: Review article
C2 - 31652306
VL - 47
SP - 1327
EP - 1339
JO - BIOCHEM SOC T
JF - BIOCHEM SOC T
SN - 0300-5127
IS - 5
ER -