cGMP signalling in cardiomyocyte microdomains

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cGMP signalling in cardiomyocyte microdomains. / Bork, Nadja I; Molina, Cristina E; Nikolaev, Viacheslav O.

in: BIOCHEM SOC T, Jahrgang 47, Nr. 5, 31.10.2019, S. 1327-1339.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ReviewForschung

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Bibtex

@article{4eb355a4e981445081f14e1fe7b38101,
title = "cGMP signalling in cardiomyocyte microdomains",
abstract = "3',5'-Cyclic guanosine monophosphate (cGMP) is one of the major second messengers critically involved in the regulation of cardiac electrophysiology, hypertrophy, and contractility. Recent molecular and cellular studies have significantly advanced our understanding of the cGMP signalling cascade, its local microdomain-specific regulation and its role in protecting the heart from pathological stress. Here, we summarise recent findings on cardiac cGMP microdomain regulation and discuss their potential clinical significance.",
keywords = "Animals, Cyclic GMP/metabolism, Humans, Myocytes, Cardiac/metabolism, Second Messenger Systems, Signal Transduction",
author = "Bork, {Nadja I} and Molina, {Cristina E} and Nikolaev, {Viacheslav O}",
note = "{\textcopyright} 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.",
year = "2019",
month = oct,
day = "31",
doi = "10.1042/BST20190225",
language = "English",
volume = "47",
pages = "1327--1339",
journal = "BIOCHEM SOC T",
issn = "0300-5127",
publisher = "PORTLAND PRESS LTD",
number = "5",

}

RIS

TY - JOUR

T1 - cGMP signalling in cardiomyocyte microdomains

AU - Bork, Nadja I

AU - Molina, Cristina E

AU - Nikolaev, Viacheslav O

N1 - © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

PY - 2019/10/31

Y1 - 2019/10/31

N2 - 3',5'-Cyclic guanosine monophosphate (cGMP) is one of the major second messengers critically involved in the regulation of cardiac electrophysiology, hypertrophy, and contractility. Recent molecular and cellular studies have significantly advanced our understanding of the cGMP signalling cascade, its local microdomain-specific regulation and its role in protecting the heart from pathological stress. Here, we summarise recent findings on cardiac cGMP microdomain regulation and discuss their potential clinical significance.

AB - 3',5'-Cyclic guanosine monophosphate (cGMP) is one of the major second messengers critically involved in the regulation of cardiac electrophysiology, hypertrophy, and contractility. Recent molecular and cellular studies have significantly advanced our understanding of the cGMP signalling cascade, its local microdomain-specific regulation and its role in protecting the heart from pathological stress. Here, we summarise recent findings on cardiac cGMP microdomain regulation and discuss their potential clinical significance.

KW - Animals

KW - Cyclic GMP/metabolism

KW - Humans

KW - Myocytes, Cardiac/metabolism

KW - Second Messenger Systems

KW - Signal Transduction

U2 - 10.1042/BST20190225

DO - 10.1042/BST20190225

M3 - SCORING: Review article

C2 - 31652306

VL - 47

SP - 1327

EP - 1339

JO - BIOCHEM SOC T

JF - BIOCHEM SOC T

SN - 0300-5127

IS - 5

ER -