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Central mesenteric lymph node BER-Ep4+ cells in colorectal cancer: challenge to sentinel node concept?

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Central mesenteric lymph node BER-Ep4+ cells in colorectal cancer: challenge to sentinel node concept? / Schurr, Paulus; Behnke, Sophia; Kaifi, Jussuf; Bogoevski, Dean; Link, Björn-Chr.; Mann, Oliver; Strate, Tim; Pantel, Klaus; Izbicki, Jakob R.; Yekebas, Emre F.

In: DIGEST SURG, Vol. 24, No. 1, 1, 2007, p. 19-27.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schurr, P, Behnke, S, Kaifi, J, Bogoevski, D, Link, B-C, Mann, O, Strate, T, Pantel, K, Izbicki, JR & Yekebas, EF 2007, 'Central mesenteric lymph node BER-Ep4+ cells in colorectal cancer: challenge to sentinel node concept?', DIGEST SURG, vol. 24, no. 1, 1, pp. 19-27. <http://www.ncbi.nlm.nih.gov/pubmed/17369677?dopt=Citation>

APA

Schurr, P., Behnke, S., Kaifi, J., Bogoevski, D., Link, B-C., Mann, O., Strate, T., Pantel, K., Izbicki, J. R., & Yekebas, E. F. (2007). Central mesenteric lymph node BER-Ep4+ cells in colorectal cancer: challenge to sentinel node concept? DIGEST SURG, 24(1), 19-27. [1]. http://www.ncbi.nlm.nih.gov/pubmed/17369677?dopt=Citation

Vancouver

Schurr P, Behnke S, Kaifi J, Bogoevski D, Link B-C, Mann O et al. Central mesenteric lymph node BER-Ep4+ cells in colorectal cancer: challenge to sentinel node concept? DIGEST SURG. 2007;24(1):19-27. 1.

Bibtex

@article{ae2f4616122e499194526ae9f2bbbf2d,
title = "Central mesenteric lymph node BER-Ep4+ cells in colorectal cancer: challenge to sentinel node concept?",
abstract = "BACKGROUND: The role of sentinel lymph nodes in colorectal cancer remains unclear. METHODS: Cryosections from central para-aortic mesenterial lymph nodes were stained using mAb BER-Ep4. Overall survival and distant recurrence were calculated using Kaplan-Meier plots. RESULTS: All patients (n = 48) were free of distant metastases and curatively resected (R0). 23 pN0, 13 pN1 and 12 pN2 stages were found. 21/48 patients (44%) showed BER-Ep4+ cells in their central lymph nodes (7/23 pN0, 8/13 pN1, 6/12 pN2). In 6/23 pN0 patients, BER-Ep4+ cells were also found in locoregional nodes (p = 0.03, Fisher's exact test). pN status predicted overall survival (p = 0.006, Kaplan-Meier curve, log-rank test). An impact was exerted by central mesenteric BER-Ep4+ cells on overall survival (p = 0.009 in pN0 patients, p = 0.07 for all pN) and distant recurrence-free survival (p = 0.001 in pN0 patients, p = 0.007 for all pN). Multivariate analysis showed an independent prognostic effect on overall survival in pN0 patients (p = 0.022). CONCLUSION: Central lymph nodes are sentinels of disease not amenable to extended lymphadenectomy and might identify patients at risk of distant organ recurrence.",
author = "Paulus Schurr and Sophia Behnke and Jussuf Kaifi and Dean Bogoevski and Bj{\"o}rn-Chr. Link and Oliver Mann and Tim Strate and Klaus Pantel and Izbicki, {Jakob R.} and Yekebas, {Emre F.}",
year = "2007",
language = "Deutsch",
volume = "24",
pages = "19--27",
journal = "DIGEST SURG",
issn = "0253-4886",
publisher = "S. Karger AG",
number = "1",

}

RIS

TY - JOUR

T1 - Central mesenteric lymph node BER-Ep4+ cells in colorectal cancer: challenge to sentinel node concept?

AU - Schurr, Paulus

AU - Behnke, Sophia

AU - Kaifi, Jussuf

AU - Bogoevski, Dean

AU - Link, Björn-Chr.

AU - Mann, Oliver

AU - Strate, Tim

AU - Pantel, Klaus

AU - Izbicki, Jakob R.

AU - Yekebas, Emre F.

PY - 2007

Y1 - 2007

N2 - BACKGROUND: The role of sentinel lymph nodes in colorectal cancer remains unclear. METHODS: Cryosections from central para-aortic mesenterial lymph nodes were stained using mAb BER-Ep4. Overall survival and distant recurrence were calculated using Kaplan-Meier plots. RESULTS: All patients (n = 48) were free of distant metastases and curatively resected (R0). 23 pN0, 13 pN1 and 12 pN2 stages were found. 21/48 patients (44%) showed BER-Ep4+ cells in their central lymph nodes (7/23 pN0, 8/13 pN1, 6/12 pN2). In 6/23 pN0 patients, BER-Ep4+ cells were also found in locoregional nodes (p = 0.03, Fisher's exact test). pN status predicted overall survival (p = 0.006, Kaplan-Meier curve, log-rank test). An impact was exerted by central mesenteric BER-Ep4+ cells on overall survival (p = 0.009 in pN0 patients, p = 0.07 for all pN) and distant recurrence-free survival (p = 0.001 in pN0 patients, p = 0.007 for all pN). Multivariate analysis showed an independent prognostic effect on overall survival in pN0 patients (p = 0.022). CONCLUSION: Central lymph nodes are sentinels of disease not amenable to extended lymphadenectomy and might identify patients at risk of distant organ recurrence.

AB - BACKGROUND: The role of sentinel lymph nodes in colorectal cancer remains unclear. METHODS: Cryosections from central para-aortic mesenterial lymph nodes were stained using mAb BER-Ep4. Overall survival and distant recurrence were calculated using Kaplan-Meier plots. RESULTS: All patients (n = 48) were free of distant metastases and curatively resected (R0). 23 pN0, 13 pN1 and 12 pN2 stages were found. 21/48 patients (44%) showed BER-Ep4+ cells in their central lymph nodes (7/23 pN0, 8/13 pN1, 6/12 pN2). In 6/23 pN0 patients, BER-Ep4+ cells were also found in locoregional nodes (p = 0.03, Fisher's exact test). pN status predicted overall survival (p = 0.006, Kaplan-Meier curve, log-rank test). An impact was exerted by central mesenteric BER-Ep4+ cells on overall survival (p = 0.009 in pN0 patients, p = 0.07 for all pN) and distant recurrence-free survival (p = 0.001 in pN0 patients, p = 0.007 for all pN). Multivariate analysis showed an independent prognostic effect on overall survival in pN0 patients (p = 0.022). CONCLUSION: Central lymph nodes are sentinels of disease not amenable to extended lymphadenectomy and might identify patients at risk of distant organ recurrence.

M3 - SCORING: Zeitschriftenaufsatz

VL - 24

SP - 19

EP - 27

JO - DIGEST SURG

JF - DIGEST SURG

SN - 0253-4886

IS - 1

M1 - 1

ER -