Central mesenteric lymph node BER-Ep4+ cells in colorectal cancer: challenge to sentinel node concept?
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Central mesenteric lymph node BER-Ep4+ cells in colorectal cancer: challenge to sentinel node concept? / Schurr, Paulus; Behnke, Sophia; Kaifi, Jussuf; Bogoevski, Dean; Link, Björn-Chr.; Mann, Oliver; Strate, Tim; Pantel, Klaus; Izbicki, Jakob R.; Yekebas, Emre F.
in: DIGEST SURG, Jahrgang 24, Nr. 1, 1, 2007, S. 19-27.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Central mesenteric lymph node BER-Ep4+ cells in colorectal cancer: challenge to sentinel node concept?
AU - Schurr, Paulus
AU - Behnke, Sophia
AU - Kaifi, Jussuf
AU - Bogoevski, Dean
AU - Link, Björn-Chr.
AU - Mann, Oliver
AU - Strate, Tim
AU - Pantel, Klaus
AU - Izbicki, Jakob R.
AU - Yekebas, Emre F.
PY - 2007
Y1 - 2007
N2 - BACKGROUND: The role of sentinel lymph nodes in colorectal cancer remains unclear. METHODS: Cryosections from central para-aortic mesenterial lymph nodes were stained using mAb BER-Ep4. Overall survival and distant recurrence were calculated using Kaplan-Meier plots. RESULTS: All patients (n = 48) were free of distant metastases and curatively resected (R0). 23 pN0, 13 pN1 and 12 pN2 stages were found. 21/48 patients (44%) showed BER-Ep4+ cells in their central lymph nodes (7/23 pN0, 8/13 pN1, 6/12 pN2). In 6/23 pN0 patients, BER-Ep4+ cells were also found in locoregional nodes (p = 0.03, Fisher's exact test). pN status predicted overall survival (p = 0.006, Kaplan-Meier curve, log-rank test). An impact was exerted by central mesenteric BER-Ep4+ cells on overall survival (p = 0.009 in pN0 patients, p = 0.07 for all pN) and distant recurrence-free survival (p = 0.001 in pN0 patients, p = 0.007 for all pN). Multivariate analysis showed an independent prognostic effect on overall survival in pN0 patients (p = 0.022). CONCLUSION: Central lymph nodes are sentinels of disease not amenable to extended lymphadenectomy and might identify patients at risk of distant organ recurrence.
AB - BACKGROUND: The role of sentinel lymph nodes in colorectal cancer remains unclear. METHODS: Cryosections from central para-aortic mesenterial lymph nodes were stained using mAb BER-Ep4. Overall survival and distant recurrence were calculated using Kaplan-Meier plots. RESULTS: All patients (n = 48) were free of distant metastases and curatively resected (R0). 23 pN0, 13 pN1 and 12 pN2 stages were found. 21/48 patients (44%) showed BER-Ep4+ cells in their central lymph nodes (7/23 pN0, 8/13 pN1, 6/12 pN2). In 6/23 pN0 patients, BER-Ep4+ cells were also found in locoregional nodes (p = 0.03, Fisher's exact test). pN status predicted overall survival (p = 0.006, Kaplan-Meier curve, log-rank test). An impact was exerted by central mesenteric BER-Ep4+ cells on overall survival (p = 0.009 in pN0 patients, p = 0.07 for all pN) and distant recurrence-free survival (p = 0.001 in pN0 patients, p = 0.007 for all pN). Multivariate analysis showed an independent prognostic effect on overall survival in pN0 patients (p = 0.022). CONCLUSION: Central lymph nodes are sentinels of disease not amenable to extended lymphadenectomy and might identify patients at risk of distant organ recurrence.
M3 - SCORING: Zeitschriftenaufsatz
VL - 24
SP - 19
EP - 27
JO - DIGEST SURG
JF - DIGEST SURG
SN - 0253-4886
IS - 1
M1 - 1
ER -