Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma
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Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma. / Roh, Vincent; Abramowski, Pierre; Hiou-Feige, Agnès; Cornils, Kerstin; Rivals, Jean-Paul; Zougman, Alexandre; Aranyossy, Tim; Thielecke, Lars; Truan, Zinnia; Mermod, Maxime; Monnier, Yan; Prassolov, Vladimir; Glauche, Ingmar; Nowrouzi, Ali; Abdollahi, Amir; Fehse, Boris; Simon, Christian; Tolstonog, Genrich V.
In: CELL REP, Vol. 25, No. 8, 20.11.2018, p. 2208-2222.e7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma
AU - Roh, Vincent
AU - Abramowski, Pierre
AU - Hiou-Feige, Agnès
AU - Cornils, Kerstin
AU - Rivals, Jean-Paul
AU - Zougman, Alexandre
AU - Aranyossy, Tim
AU - Thielecke, Lars
AU - Truan, Zinnia
AU - Mermod, Maxime
AU - Monnier, Yan
AU - Prassolov, Vladimir
AU - Glauche, Ingmar
AU - Nowrouzi, Ali
AU - Abdollahi, Amir
AU - Fehse, Boris
AU - Simon, Christian
AU - Tolstonog, Genrich V
N1 - Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.
PY - 2018/11/20
Y1 - 2018/11/20
N2 - Local recurrence after surgery for head and neck squamous cell carcinoma (HNSCC) remains a common event associated with a dismal prognosis. Improving this outcome requires a better understanding of cancer cell populations that expand from postsurgical minimal residual disease (MRD). Therefore, we assessed clonal dynamics in a surgical model of barcoded HNSCC growing in the submental region of immunodeficient mice. Clonal substitution and massive reduction of clonal heterogeneity emerged as hallmarks of local recurrence, as the clones dominating in less heterogeneous recurrences were scarce in their matched primary tumors. These lineages were selected by their ability to persist after surgery and competitively expand from MRD. Clones enriched in recurrences exhibited both private and shared genetic features and likely originated from ancestors shared with clones dominating in primary tumors. They demonstrated high invasiveness and epithelial-to-mesenchymal transition, eventually providing an attractive target for obtaining better local control for these tumors.
AB - Local recurrence after surgery for head and neck squamous cell carcinoma (HNSCC) remains a common event associated with a dismal prognosis. Improving this outcome requires a better understanding of cancer cell populations that expand from postsurgical minimal residual disease (MRD). Therefore, we assessed clonal dynamics in a surgical model of barcoded HNSCC growing in the submental region of immunodeficient mice. Clonal substitution and massive reduction of clonal heterogeneity emerged as hallmarks of local recurrence, as the clones dominating in less heterogeneous recurrences were scarce in their matched primary tumors. These lineages were selected by their ability to persist after surgery and competitively expand from MRD. Clones enriched in recurrences exhibited both private and shared genetic features and likely originated from ancestors shared with clones dominating in primary tumors. They demonstrated high invasiveness and epithelial-to-mesenchymal transition, eventually providing an attractive target for obtaining better local control for these tumors.
KW - Journal Article
U2 - 10.1016/j.celrep.2018.10.090
DO - 10.1016/j.celrep.2018.10.090
M3 - SCORING: Journal article
C2 - 30463016
VL - 25
SP - 2208-2222.e7
JO - CELL REP
JF - CELL REP
SN - 2211-1247
IS - 8
ER -