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Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma

Standard

Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma. / Roh, Vincent; Abramowski, Pierre; Hiou-Feige, Agnès; Cornils, Kerstin; Rivals, Jean-Paul; Zougman, Alexandre; Aranyossy, Tim; Thielecke, Lars; Truan, Zinnia; Mermod, Maxime; Monnier, Yan; Prassolov, Vladimir; Glauche, Ingmar; Nowrouzi, Ali; Abdollahi, Amir; Fehse, Boris; Simon, Christian; Tolstonog, Genrich V.

in: CELL REP, Jahrgang 25, Nr. 8, 20.11.2018, S. 2208-2222.e7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Roh, V, Abramowski, P, Hiou-Feige, A, Cornils, K, Rivals, J-P, Zougman, A, Aranyossy, T, Thielecke, L, Truan, Z, Mermod, M, Monnier, Y, Prassolov, V, Glauche, I, Nowrouzi, A, Abdollahi, A, Fehse, B, Simon, C & Tolstonog, GV 2018, 'Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma', CELL REP, Jg. 25, Nr. 8, S. 2208-2222.e7. https://doi.org/10.1016/j.celrep.2018.10.090

APA

Roh, V., Abramowski, P., Hiou-Feige, A., Cornils, K., Rivals, J-P., Zougman, A., Aranyossy, T., Thielecke, L., Truan, Z., Mermod, M., Monnier, Y., Prassolov, V., Glauche, I., Nowrouzi, A., Abdollahi, A., Fehse, B., Simon, C., & Tolstonog, G. V. (2018). Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma. CELL REP, 25(8), 2208-2222.e7. https://doi.org/10.1016/j.celrep.2018.10.090

Vancouver

Roh V, Abramowski P, Hiou-Feige A, Cornils K, Rivals J-P, Zougman A et al. Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma. CELL REP. 2018 Nov 20;25(8):2208-2222.e7. https://doi.org/10.1016/j.celrep.2018.10.090

Bibtex

@article{1d49510a8f2c48e0b2205be25cf51a47,
title = "Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma",
abstract = "Local recurrence after surgery for head and neck squamous cell carcinoma (HNSCC) remains a common event associated with a dismal prognosis. Improving this outcome requires a better understanding of cancer cell populations that expand from postsurgical minimal residual disease (MRD). Therefore, we assessed clonal dynamics in a surgical model of barcoded HNSCC growing in the submental region of immunodeficient mice. Clonal substitution and massive reduction of clonal heterogeneity emerged as hallmarks of local recurrence, as the clones dominating in less heterogeneous recurrences were scarce in their matched primary tumors. These lineages were selected by their ability to persist after surgery and competitively expand from MRD. Clones enriched in recurrences exhibited both private and shared genetic features and likely originated from ancestors shared with clones dominating in primary tumors. They demonstrated high invasiveness and epithelial-to-mesenchymal transition, eventually providing an attractive target for obtaining better local control for these tumors.",
keywords = "Journal Article",
author = "Vincent Roh and Pierre Abramowski and Agn{\`e}s Hiou-Feige and Kerstin Cornils and Jean-Paul Rivals and Alexandre Zougman and Tim Aranyossy and Lars Thielecke and Zinnia Truan and Maxime Mermod and Yan Monnier and Vladimir Prassolov and Ingmar Glauche and Ali Nowrouzi and Amir Abdollahi and Boris Fehse and Christian Simon and Tolstonog, {Genrich V}",
note = "Copyright {\textcopyright} 2018 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2018",
month = nov,
day = "20",
doi = "10.1016/j.celrep.2018.10.090",
language = "English",
volume = "25",
pages = "2208--2222.e7",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "8",

}

RIS

TY - JOUR

T1 - Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma

AU - Roh, Vincent

AU - Abramowski, Pierre

AU - Hiou-Feige, Agnès

AU - Cornils, Kerstin

AU - Rivals, Jean-Paul

AU - Zougman, Alexandre

AU - Aranyossy, Tim

AU - Thielecke, Lars

AU - Truan, Zinnia

AU - Mermod, Maxime

AU - Monnier, Yan

AU - Prassolov, Vladimir

AU - Glauche, Ingmar

AU - Nowrouzi, Ali

AU - Abdollahi, Amir

AU - Fehse, Boris

AU - Simon, Christian

AU - Tolstonog, Genrich V

N1 - Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2018/11/20

Y1 - 2018/11/20

N2 - Local recurrence after surgery for head and neck squamous cell carcinoma (HNSCC) remains a common event associated with a dismal prognosis. Improving this outcome requires a better understanding of cancer cell populations that expand from postsurgical minimal residual disease (MRD). Therefore, we assessed clonal dynamics in a surgical model of barcoded HNSCC growing in the submental region of immunodeficient mice. Clonal substitution and massive reduction of clonal heterogeneity emerged as hallmarks of local recurrence, as the clones dominating in less heterogeneous recurrences were scarce in their matched primary tumors. These lineages were selected by their ability to persist after surgery and competitively expand from MRD. Clones enriched in recurrences exhibited both private and shared genetic features and likely originated from ancestors shared with clones dominating in primary tumors. They demonstrated high invasiveness and epithelial-to-mesenchymal transition, eventually providing an attractive target for obtaining better local control for these tumors.

AB - Local recurrence after surgery for head and neck squamous cell carcinoma (HNSCC) remains a common event associated with a dismal prognosis. Improving this outcome requires a better understanding of cancer cell populations that expand from postsurgical minimal residual disease (MRD). Therefore, we assessed clonal dynamics in a surgical model of barcoded HNSCC growing in the submental region of immunodeficient mice. Clonal substitution and massive reduction of clonal heterogeneity emerged as hallmarks of local recurrence, as the clones dominating in less heterogeneous recurrences were scarce in their matched primary tumors. These lineages were selected by their ability to persist after surgery and competitively expand from MRD. Clones enriched in recurrences exhibited both private and shared genetic features and likely originated from ancestors shared with clones dominating in primary tumors. They demonstrated high invasiveness and epithelial-to-mesenchymal transition, eventually providing an attractive target for obtaining better local control for these tumors.

KW - Journal Article

U2 - 10.1016/j.celrep.2018.10.090

DO - 10.1016/j.celrep.2018.10.090

M3 - SCORING: Journal article

C2 - 30463016

VL - 25

SP - 2208-2222.e7

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 8

ER -