Cells of the adult human heart
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Cells of the adult human heart. / Litviňuková, Monika; Talavera-López, Carlos; Maatz, Henrike; Reichart, Daniel; Worth, Catherine L; Lindberg, Eric L; Kanda, Masatoshi; Polanski, Krzysztof; Heinig, Matthias; Lee, Michael; Nadelmann, Emily R; Roberts, Kenny; Tuck, Liz; Fasouli, Eirini S; DeLaughter, Daniel M; McDonough, Barbara; Wakimoto, Hiroko; Gorham, Joshua M; Samari, Sara; Mahbubani, Krishnaa T; Saeb-Parsy, Kourosh; Patone, Giannino; Boyle, Joseph J; Zhang, Hongbo; Zhang, Hao; Viveiros, Anissa; Oudit, Gavin Y; Bayraktar, Omer Ali; Seidman, J G; Seidman, Christine E; Noseda, Michela; Hubner, Norbert; Teichmann, Sarah A.
In: NATURE, Vol. 588, No. 7838, 12.2020, p. 466-472.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Cells of the adult human heart
AU - Litviňuková, Monika
AU - Talavera-López, Carlos
AU - Maatz, Henrike
AU - Reichart, Daniel
AU - Worth, Catherine L
AU - Lindberg, Eric L
AU - Kanda, Masatoshi
AU - Polanski, Krzysztof
AU - Heinig, Matthias
AU - Lee, Michael
AU - Nadelmann, Emily R
AU - Roberts, Kenny
AU - Tuck, Liz
AU - Fasouli, Eirini S
AU - DeLaughter, Daniel M
AU - McDonough, Barbara
AU - Wakimoto, Hiroko
AU - Gorham, Joshua M
AU - Samari, Sara
AU - Mahbubani, Krishnaa T
AU - Saeb-Parsy, Kourosh
AU - Patone, Giannino
AU - Boyle, Joseph J
AU - Zhang, Hongbo
AU - Zhang, Hao
AU - Viveiros, Anissa
AU - Oudit, Gavin Y
AU - Bayraktar, Omer Ali
AU - Seidman, J G
AU - Seidman, Christine E
AU - Noseda, Michela
AU - Hubner, Norbert
AU - Teichmann, Sarah A
PY - 2020/12
Y1 - 2020/12
N2 - Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies.
AB - Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies.
KW - Adipocytes/classification
KW - Adult
KW - Angiotensin-Converting Enzyme 2/analysis
KW - Epithelial Cells/classification
KW - Epithelium
KW - Female
KW - Fibroblasts/classification
KW - Gene Expression Profiling
KW - Genome-Wide Association Study
KW - Heart Atria/anatomy & histology
KW - Heart Ventricles/anatomy & histology
KW - Homeostasis/immunology
KW - Humans
KW - Macrophages/immunology
KW - Male
KW - Muscle, Skeletal/cytology
KW - Myocardium/cytology
KW - Myocytes, Cardiac/classification
KW - Neurons/classification
KW - Pericytes/classification
KW - Receptors, Coronavirus/analysis
KW - SARS-CoV-2/metabolism
KW - Single-Cell Analysis
KW - Stromal Cells/classification
KW - Transcriptome
U2 - 10.1038/s41586-020-2797-4
DO - 10.1038/s41586-020-2797-4
M3 - SCORING: Journal article
C2 - 32971526
VL - 588
SP - 466
EP - 472
JO - NATURE
JF - NATURE
SN - 0028-0836
IS - 7838
ER -