PortalPublikationenCells of the adult human heart

Cells of the adult human heart

Standard

Cells of the adult human heart. / Litviňuková, Monika; Talavera-López, Carlos; Maatz, Henrike; Reichart, Daniel; Worth, Catherine L; Lindberg, Eric L; Kanda, Masatoshi; Polanski, Krzysztof; Heinig, Matthias; Lee, Michael; Nadelmann, Emily R; Roberts, Kenny; Tuck, Liz; Fasouli, Eirini S; DeLaughter, Daniel M; McDonough, Barbara; Wakimoto, Hiroko; Gorham, Joshua M; Samari, Sara; Mahbubani, Krishnaa T; Saeb-Parsy, Kourosh; Patone, Giannino; Boyle, Joseph J; Zhang, Hongbo; Zhang, Hao; Viveiros, Anissa; Oudit, Gavin Y; Bayraktar, Omer Ali; Seidman, J G; Seidman, Christine E; Noseda, Michela; Hubner, Norbert; Teichmann, Sarah A.

in: NATURE, Jahrgang 588, Nr. 7838, 12.2020, S. 466-472.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Litviňuková, M, Talavera-López, C, Maatz, H, Reichart, D, Worth, CL, Lindberg, EL, Kanda, M, Polanski, K, Heinig, M, Lee, M, Nadelmann, ER, Roberts, K, Tuck, L, Fasouli, ES, DeLaughter, DM, McDonough, B, Wakimoto, H, Gorham, JM, Samari, S, Mahbubani, KT, Saeb-Parsy, K, Patone, G, Boyle, JJ, Zhang, H, Zhang, H, Viveiros, A, Oudit, GY, Bayraktar, OA, Seidman, JG, Seidman, CE, Noseda, M, Hubner, N & Teichmann, SA 2020, 'Cells of the adult human heart', NATURE, Jg. 588, Nr. 7838, S. 466-472. https://doi.org/10.1038/s41586-020-2797-4

APA

Litviňuková, M., Talavera-López, C., Maatz, H., Reichart, D., Worth, C. L., Lindberg, E. L., Kanda, M., Polanski, K., Heinig, M., Lee, M., Nadelmann, E. R., Roberts, K., Tuck, L., Fasouli, E. S., DeLaughter, D. M., McDonough, B., Wakimoto, H., Gorham, J. M., Samari, S., ... Teichmann, S. A. (2020). Cells of the adult human heart. NATURE, 588(7838), 466-472. https://doi.org/10.1038/s41586-020-2797-4

Vancouver

Litviňuková M, Talavera-López C, Maatz H, Reichart D, Worth CL, Lindberg EL et al. Cells of the adult human heart. NATURE. 2020 Dez;588(7838):466-472. https://doi.org/10.1038/s41586-020-2797-4

Bibtex

@article{b06e8976c8174d739af5dc0dc0d4cc38,
title = "Cells of the adult human heart",
abstract = "Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies.",
keywords = "Adipocytes/classification, Adult, Angiotensin-Converting Enzyme 2/analysis, Epithelial Cells/classification, Epithelium, Female, Fibroblasts/classification, Gene Expression Profiling, Genome-Wide Association Study, Heart Atria/anatomy & histology, Heart Ventricles/anatomy & histology, Homeostasis/immunology, Humans, Macrophages/immunology, Male, Muscle, Skeletal/cytology, Myocardium/cytology, Myocytes, Cardiac/classification, Neurons/classification, Pericytes/classification, Receptors, Coronavirus/analysis, SARS-CoV-2/metabolism, Single-Cell Analysis, Stromal Cells/classification, Transcriptome",
author = "Monika Litvi{\v n}ukov{\'a} and Carlos Talavera-L{\'o}pez and Henrike Maatz and Daniel Reichart and Worth, {Catherine L} and Lindberg, {Eric L} and Masatoshi Kanda and Krzysztof Polanski and Matthias Heinig and Michael Lee and Nadelmann, {Emily R} and Kenny Roberts and Liz Tuck and Fasouli, {Eirini S} and DeLaughter, {Daniel M} and Barbara McDonough and Hiroko Wakimoto and Gorham, {Joshua M} and Sara Samari and Mahbubani, {Krishnaa T} and Kourosh Saeb-Parsy and Giannino Patone and Boyle, {Joseph J} and Hongbo Zhang and Hao Zhang and Anissa Viveiros and Oudit, {Gavin Y} and Bayraktar, {Omer Ali} and Seidman, {J G} and Seidman, {Christine E} and Michela Noseda and Norbert Hubner and Teichmann, {Sarah A}",
year = "2020",
month = dec,
doi = "10.1038/s41586-020-2797-4",
language = "English",
volume = "588",
pages = "466--472",
journal = "NATURE",
issn = "0028-0836",
publisher = "NATURE PUBLISHING GROUP",
number = "7838",

}

RIS

TY - JOUR

T1 - Cells of the adult human heart

AU - Litviňuková, Monika

AU - Talavera-López, Carlos

AU - Maatz, Henrike

AU - Reichart, Daniel

AU - Worth, Catherine L

AU - Lindberg, Eric L

AU - Kanda, Masatoshi

AU - Polanski, Krzysztof

AU - Heinig, Matthias

AU - Lee, Michael

AU - Nadelmann, Emily R

AU - Roberts, Kenny

AU - Tuck, Liz

AU - Fasouli, Eirini S

AU - DeLaughter, Daniel M

AU - McDonough, Barbara

AU - Wakimoto, Hiroko

AU - Gorham, Joshua M

AU - Samari, Sara

AU - Mahbubani, Krishnaa T

AU - Saeb-Parsy, Kourosh

AU - Patone, Giannino

AU - Boyle, Joseph J

AU - Zhang, Hongbo

AU - Zhang, Hao

AU - Viveiros, Anissa

AU - Oudit, Gavin Y

AU - Bayraktar, Omer Ali

AU - Seidman, J G

AU - Seidman, Christine E

AU - Noseda, Michela

AU - Hubner, Norbert

AU - Teichmann, Sarah A

PY - 2020/12

Y1 - 2020/12

N2 - Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies.

AB - Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies.

KW - Adipocytes/classification

KW - Adult

KW - Angiotensin-Converting Enzyme 2/analysis

KW - Epithelial Cells/classification

KW - Epithelium

KW - Female

KW - Fibroblasts/classification

KW - Gene Expression Profiling

KW - Genome-Wide Association Study

KW - Heart Atria/anatomy & histology

KW - Heart Ventricles/anatomy & histology

KW - Homeostasis/immunology

KW - Humans

KW - Macrophages/immunology

KW - Male

KW - Muscle, Skeletal/cytology

KW - Myocardium/cytology

KW - Myocytes, Cardiac/classification

KW - Neurons/classification

KW - Pericytes/classification

KW - Receptors, Coronavirus/analysis

KW - SARS-CoV-2/metabolism

KW - Single-Cell Analysis

KW - Stromal Cells/classification

KW - Transcriptome

U2 - 10.1038/s41586-020-2797-4

DO - 10.1038/s41586-020-2797-4

M3 - SCORING: Journal article

C2 - 32971526

VL - 588

SP - 466

EP - 472

JO - NATURE

JF - NATURE

SN - 0028-0836

IS - 7838

ER -