Cell-free nucleic acids as biomarkers in cancer patients.
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Cell-free nucleic acids as biomarkers in cancer patients. / Schwarzenbach, Heidi; Hoon, Dave S B; Pantel, Klaus.
In: NAT REV CANCER, Vol. 11, No. 6, 6, 2011, p. 426-437.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Cell-free nucleic acids as biomarkers in cancer patients.
AU - Schwarzenbach, Heidi
AU - Hoon, Dave S B
AU - Pantel, Klaus
PY - 2011
Y1 - 2011
N2 - DNA, mRNA and microRNA are released and circulate in the blood of cancer patients. Changes in the levels of circulating nucleic acids have been associated with tumour burden and malignant progression. In the past decade a wealth of information indicating the potential use of circulating nucleic acids for cancer screening, prognosis and monitoring of the efficacy of anticancer therapies has emerged. In this Review, we discuss these findings with a specific focus on the clinical utility of cell-free nucleic acids as blood biomarkers.
AB - DNA, mRNA and microRNA are released and circulate in the blood of cancer patients. Changes in the levels of circulating nucleic acids have been associated with tumour burden and malignant progression. In the past decade a wealth of information indicating the potential use of circulating nucleic acids for cancer screening, prognosis and monitoring of the efficacy of anticancer therapies has emerged. In this Review, we discuss these findings with a specific focus on the clinical utility of cell-free nucleic acids as blood biomarkers.
KW - Humans
KW - Mutation
KW - Apoptosis
KW - DNA/blood
KW - DNA, Viral/blood
KW - MicroRNAs/blood
KW - Neoplasms/blood/genetics
KW - RNA, Messenger/blood
KW - Tumor Markers, Biological/blood
KW - Humans
KW - Mutation
KW - Apoptosis
KW - DNA/blood
KW - DNA, Viral/blood
KW - MicroRNAs/blood
KW - Neoplasms/blood/genetics
KW - RNA, Messenger/blood
KW - Tumor Markers, Biological/blood
M3 - SCORING: Journal article
VL - 11
SP - 426
EP - 437
JO - NAT REV CANCER
JF - NAT REV CANCER
SN - 1474-175X
IS - 6
M1 - 6
ER -