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Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication.

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Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. / Mouysset, Julien; Deichsel, Alexandra; Moser, Sandra; Hoege, Carsten; Hyman, Anthony A; Gartner, Anton; Hoppe, Thorsten.

In: P NATL ACAD SCI USA, Vol. 105, No. 35, 35, 2008, p. 12879-12884.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mouysset, J, Deichsel, A, Moser, S, Hoege, C, Hyman, AA, Gartner, A & Hoppe, T 2008, 'Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication.', P NATL ACAD SCI USA, vol. 105, no. 35, 35, pp. 12879-12884. <http://www.ncbi.nlm.nih.gov/pubmed/18728180?dopt=Citation>

APA

Mouysset, J., Deichsel, A., Moser, S., Hoege, C., Hyman, A. A., Gartner, A., & Hoppe, T. (2008). Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. P NATL ACAD SCI USA, 105(35), 12879-12884. [35]. http://www.ncbi.nlm.nih.gov/pubmed/18728180?dopt=Citation

Vancouver

Mouysset J, Deichsel A, Moser S, Hoege C, Hyman AA, Gartner A et al. Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. P NATL ACAD SCI USA. 2008;105(35):12879-12884. 35.

Bibtex

@article{b8a7f8ba15c74ccaa0d29c40f864627e,
title = "Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication.",
abstract = "Since cdc48 mutants were isolated by the first genetic screens for cell division cycle (cdc) mutants in yeast, the requirement of the chaperone-like ATPase Cdc48/p97 during cell division has remained unclear. Here, we discover an unanticipated function for Caenorhabditis elegans CDC-48 in DNA replication linked to cell cycle control. Our analysis of the CDC-48(UFD-1/NPL-4) complex identified a general role in S phase progression of mitotic cells essential for embryonic cell division and germline development of adult worms. These developmental defects result from activation of the DNA replication checkpoint caused by replication stress. Similar to loss of replication licensing factors, DNA content is strongly reduced in worms depleted for CDC-48, UFD-1, and NPL-4. In addition, these worms show decreased DNA synthesis and hypersensitivity toward replication blocking agents. Our findings identified a role for CDC-48(UFD-1/NPL-4) in DNA replication, which is important for cell cycle progression and genome stability.",
author = "Julien Mouysset and Alexandra Deichsel and Sandra Moser and Carsten Hoege and Hyman, {Anthony A} and Anton Gartner and Thorsten Hoppe",
year = "2008",
language = "Deutsch",
volume = "105",
pages = "12879--12884",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "35",

}

RIS

TY - JOUR

T1 - Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication.

AU - Mouysset, Julien

AU - Deichsel, Alexandra

AU - Moser, Sandra

AU - Hoege, Carsten

AU - Hyman, Anthony A

AU - Gartner, Anton

AU - Hoppe, Thorsten

PY - 2008

Y1 - 2008

N2 - Since cdc48 mutants were isolated by the first genetic screens for cell division cycle (cdc) mutants in yeast, the requirement of the chaperone-like ATPase Cdc48/p97 during cell division has remained unclear. Here, we discover an unanticipated function for Caenorhabditis elegans CDC-48 in DNA replication linked to cell cycle control. Our analysis of the CDC-48(UFD-1/NPL-4) complex identified a general role in S phase progression of mitotic cells essential for embryonic cell division and germline development of adult worms. These developmental defects result from activation of the DNA replication checkpoint caused by replication stress. Similar to loss of replication licensing factors, DNA content is strongly reduced in worms depleted for CDC-48, UFD-1, and NPL-4. In addition, these worms show decreased DNA synthesis and hypersensitivity toward replication blocking agents. Our findings identified a role for CDC-48(UFD-1/NPL-4) in DNA replication, which is important for cell cycle progression and genome stability.

AB - Since cdc48 mutants were isolated by the first genetic screens for cell division cycle (cdc) mutants in yeast, the requirement of the chaperone-like ATPase Cdc48/p97 during cell division has remained unclear. Here, we discover an unanticipated function for Caenorhabditis elegans CDC-48 in DNA replication linked to cell cycle control. Our analysis of the CDC-48(UFD-1/NPL-4) complex identified a general role in S phase progression of mitotic cells essential for embryonic cell division and germline development of adult worms. These developmental defects result from activation of the DNA replication checkpoint caused by replication stress. Similar to loss of replication licensing factors, DNA content is strongly reduced in worms depleted for CDC-48, UFD-1, and NPL-4. In addition, these worms show decreased DNA synthesis and hypersensitivity toward replication blocking agents. Our findings identified a role for CDC-48(UFD-1/NPL-4) in DNA replication, which is important for cell cycle progression and genome stability.

M3 - SCORING: Zeitschriftenaufsatz

VL - 105

SP - 12879

EP - 12884

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 35

M1 - 35

ER -