CDKN1B, encoding the cyclin-dependent kinase inhibitor 1B (p27), is located in the minimally deleted region of 12p abnormalities in myeloid malignancies and its low expression is a favorable prognostic marker in acute myeloid leukemia.

Claudia Haferlach; Ulrike Bacher; Alexander Kohlmann; Sonja Schindela; Tamara Alpermann; Wolfgang Kern; Susanne Schnittger; Torsten Haferlach

doi:10.3324/haematol.2010.035584

CDKN1B, encoding the cyclin-dependent kinase inhibitor 1B (p27), is located in the minimally deleted region of 12p abnormalities in myeloid malignancies and its low expression is a favorable prognostic marker in acute myeloid leukemia.

Claudia Haferlach
Ulrike Bacher
Alexander Kohlmann
Sonja Schindela
Tamara Alpermann
Wolfgang Kern
Susanne Schnittger
Torsten Haferlach

Related Research units

Department of Stem Cell Transplantation

Abstract

Alterations of the short arm of chromosome 12 (12p) occur in various hematologic malignancies and ETV6 and CDKN1B, which are located on 12p, have been implicated as leukemogenic genes of interest.

Bibliographical data

Original language	English
Article number	6
ISSN	0390-6078
DOIs	https://doi.org/10.3324/haematol.2010.035584
Publication status	Published - 2011

pubmed	21422114