CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12
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CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12. / Paust, Hans-Joachim; Song, Ning; De Feo, Donatella; Asada, Nariaki; Tuzlak, Selma; Zhao, Yu; Riedel, Jan-Hendrik; Hellmig, Malte; Sivayoganathan, Amirrtavarshni; Peters, Anett; Kaffke, Anna; Borchers, Alina; Wenzel, Ulrich O; Steinmetz, Oliver M; Tiegs, Gisa; Meister, Elisabeth; Mack, Matthias; Kurts, Christian; von Vietinghoff, Sibylle; Lindenmeyer, Maja T; Hoxha, Elion; Stahl, Rolf A K; Huber, Tobias B; Bonn, Stefan; Meyer-Schwesinger, Catherine; Wiech, Thorsten; Turner, Jan-Eric; Becher, Burkhard; Krebs, Christian F; Panzer, Ulf.
In: SCI TRANSL MED, Vol. 15, No. 687, eadd6137, 15.03.2023.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12
AU - Paust, Hans-Joachim
AU - Song, Ning
AU - De Feo, Donatella
AU - Asada, Nariaki
AU - Tuzlak, Selma
AU - Zhao, Yu
AU - Riedel, Jan-Hendrik
AU - Hellmig, Malte
AU - Sivayoganathan, Amirrtavarshni
AU - Peters, Anett
AU - Kaffke, Anna
AU - Borchers, Alina
AU - Wenzel, Ulrich O
AU - Steinmetz, Oliver M
AU - Tiegs, Gisa
AU - Meister, Elisabeth
AU - Mack, Matthias
AU - Kurts, Christian
AU - von Vietinghoff, Sibylle
AU - Lindenmeyer, Maja T
AU - Hoxha, Elion
AU - Stahl, Rolf A K
AU - Huber, Tobias B
AU - Bonn, Stefan
AU - Meyer-Schwesinger, Catherine
AU - Wiech, Thorsten
AU - Turner, Jan-Eric
AU - Becher, Burkhard
AU - Krebs, Christian F
AU - Panzer, Ulf
PY - 2023/3/15
Y1 - 2023/3/15
N2 - GM-CSF in glomerulonephritisDespite glomerulonephritis being an immune-mediated disease, the contributions of individual immune cell types are not clear. To address this gap in knowledge, Paust et al. characterized pathological immune cells in samples from patients with glomerulonephritis and in samples from mice with the disease. The authors found that CD4+ T cells producing granulocyte-macrophage colony-stimulating factor (GM-CSF) licensed monocytes to promote disease by producing matrix metalloproteinase 12 and disrupting the glomerular basement membrane. Targeting GM-CSF to inhibit this axis reduced disease severity in mice, implicating this cytokine as a potential therapeutic target for patients with glomerulonephritis. -CM.
AB - GM-CSF in glomerulonephritisDespite glomerulonephritis being an immune-mediated disease, the contributions of individual immune cell types are not clear. To address this gap in knowledge, Paust et al. characterized pathological immune cells in samples from patients with glomerulonephritis and in samples from mice with the disease. The authors found that CD4+ T cells producing granulocyte-macrophage colony-stimulating factor (GM-CSF) licensed monocytes to promote disease by producing matrix metalloproteinase 12 and disrupting the glomerular basement membrane. Targeting GM-CSF to inhibit this axis reduced disease severity in mice, implicating this cytokine as a potential therapeutic target for patients with glomerulonephritis. -CM.
KW - Mice
KW - Animals
KW - Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology
KW - Monocytes/metabolism
KW - Matrix Metalloproteinase 12/metabolism
KW - CD4-Positive T-Lymphocytes
KW - Glomerulonephritis/metabolism
U2 - 10.1126/scitranslmed.add6137
DO - 10.1126/scitranslmed.add6137
M3 - SCORING: Journal article
C2 - 36921033
VL - 15
JO - SCI TRANSL MED
JF - SCI TRANSL MED
SN - 1946-6234
IS - 687
M1 - eadd6137
ER -