Cartilage degeneration post-meniscectomy performed for degenerative disease versus trauma: data from the Osteoarthritis Initiative
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Cartilage degeneration post-meniscectomy performed for degenerative disease versus trauma: data from the Osteoarthritis Initiative. / Neumann, Jan; Kern, Kai; Sun, Dong; Foreman, Sarah C; Joseph, Gabby B; Gersing, Alexandra S; Nevitt, Michael C; McCulloch, Charles E; Quitzke, Azien; Link, Thomas M.
In: SKELETAL RADIOL, Vol. 49, No. 2, 02.2020, p. 231-240.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Cartilage degeneration post-meniscectomy performed for degenerative disease versus trauma: data from the Osteoarthritis Initiative
AU - Neumann, Jan
AU - Kern, Kai
AU - Sun, Dong
AU - Foreman, Sarah C
AU - Joseph, Gabby B
AU - Gersing, Alexandra S
AU - Nevitt, Michael C
AU - McCulloch, Charles E
AU - Quitzke, Azien
AU - Link, Thomas M
PY - 2020/2
Y1 - 2020/2
N2 - OBJECTIVE: To compare the extent of cartilage deterioration in knees with prior meniscal resection related to trauma versus knees with resection related to degenerative disease, and to compare cartilage deterioration in knees with meniscal surgery to knees without meniscal surgery, controlling for prior knee trauma.MATERIALS AND METHODS: In this cross-sectional study, we assessed cartilage deterioration in right knees of Osteoarthritis Initiative participants: (i) with meniscal surgery due to injury (n = 79); (ii) matched control knees with a prior injury but without meniscal surgery (n = 79); (iii) with meniscal surgery but without preceding injury (n = 36); and (iv) matched control knees without meniscal surgery or prior knee injury (n = 36). Cartilage composition was measured using T2 measurements derived using semi-automatic cartilage segmentation of the right. Linear regression analysis was used to compare compartmental values of T2 between groups.RESULTS: Comparing the mean T2 values in surgical cases with and without injury our results did not show significant differences (group i vs. iii, p > 0.05). However, knees with previous meniscal surgery showed significantly (p < 0.001) higher mean T2 values across all compartments (i.e., global T2) when compared to those without meniscal surgery for both knees with a history of trauma (group i vs. ii) and knees without prior trauma (group iii vs. iv). Similar results were obtained when analyzing the compartments separately.CONCLUSIONS: Cartilage deterioration, assessed by T2, is similar in knees undergoing meniscal surgery after trauma and for degenerative conditions. Both groups demonstrated greater cartilage deterioration than nonsurgical knees, controlling for prior knee injury.
AB - OBJECTIVE: To compare the extent of cartilage deterioration in knees with prior meniscal resection related to trauma versus knees with resection related to degenerative disease, and to compare cartilage deterioration in knees with meniscal surgery to knees without meniscal surgery, controlling for prior knee trauma.MATERIALS AND METHODS: In this cross-sectional study, we assessed cartilage deterioration in right knees of Osteoarthritis Initiative participants: (i) with meniscal surgery due to injury (n = 79); (ii) matched control knees with a prior injury but without meniscal surgery (n = 79); (iii) with meniscal surgery but without preceding injury (n = 36); and (iv) matched control knees without meniscal surgery or prior knee injury (n = 36). Cartilage composition was measured using T2 measurements derived using semi-automatic cartilage segmentation of the right. Linear regression analysis was used to compare compartmental values of T2 between groups.RESULTS: Comparing the mean T2 values in surgical cases with and without injury our results did not show significant differences (group i vs. iii, p > 0.05). However, knees with previous meniscal surgery showed significantly (p < 0.001) higher mean T2 values across all compartments (i.e., global T2) when compared to those without meniscal surgery for both knees with a history of trauma (group i vs. ii) and knees without prior trauma (group iii vs. iv). Similar results were obtained when analyzing the compartments separately.CONCLUSIONS: Cartilage deterioration, assessed by T2, is similar in knees undergoing meniscal surgery after trauma and for degenerative conditions. Both groups demonstrated greater cartilage deterioration than nonsurgical knees, controlling for prior knee injury.
KW - Aged
KW - Cartilage Diseases/diagnostic imaging
KW - Cartilage, Articular/diagnostic imaging
KW - Cohort Studies
KW - Cross-Sectional Studies
KW - Female
KW - Humans
KW - Knee Injuries/surgery
KW - Magnetic Resonance Imaging/methods
KW - Male
KW - Meniscectomy
KW - Menisci, Tibial/diagnostic imaging
KW - Middle Aged
KW - Osteoarthritis, Knee/surgery
KW - Postoperative Complications/diagnostic imaging
KW - United States
U2 - 10.1007/s00256-019-03267-0
DO - 10.1007/s00256-019-03267-0
M3 - SCORING: Journal article
C2 - 31289901
VL - 49
SP - 231
EP - 240
JO - SKELETAL RADIOL
JF - SKELETAL RADIOL
SN - 0364-2348
IS - 2
ER -