Cartilage degeneration post-meniscectomy performed for degenerative disease versus trauma: data from the Osteoarthritis Initiative

TY - JOUR

T1 - Cartilage degeneration post-meniscectomy performed for degenerative disease versus trauma: data from the Osteoarthritis Initiative

AU - Neumann, Jan

AU - Kern, Kai

AU - Sun, Dong

AU - Foreman, Sarah C

AU - Joseph, Gabby B

AU - Gersing, Alexandra S

AU - Nevitt, Michael C

AU - McCulloch, Charles E

AU - Quitzke, Azien

AU - Link, Thomas M

PY - 2020/2

Y1 - 2020/2

N2 - OBJECTIVE: To compare the extent of cartilage deterioration in knees with prior meniscal resection related to trauma versus knees with resection related to degenerative disease, and to compare cartilage deterioration in knees with meniscal surgery to knees without meniscal surgery, controlling for prior knee trauma.MATERIALS AND METHODS: In this cross-sectional study, we assessed cartilage deterioration in right knees of Osteoarthritis Initiative participants: (i) with meniscal surgery due to injury (n = 79); (ii) matched control knees with a prior injury but without meniscal surgery (n = 79); (iii) with meniscal surgery but without preceding injury (n = 36); and (iv) matched control knees without meniscal surgery or prior knee injury (n = 36). Cartilage composition was measured using T2 measurements derived using semi-automatic cartilage segmentation of the right. Linear regression analysis was used to compare compartmental values of T2 between groups.RESULTS: Comparing the mean T2 values in surgical cases with and without injury our results did not show significant differences (group i vs. iii, p > 0.05). However, knees with previous meniscal surgery showed significantly (p < 0.001) higher mean T2 values across all compartments (i.e., global T2) when compared to those without meniscal surgery for both knees with a history of trauma (group i vs. ii) and knees without prior trauma (group iii vs. iv). Similar results were obtained when analyzing the compartments separately.CONCLUSIONS: Cartilage deterioration, assessed by T2, is similar in knees undergoing meniscal surgery after trauma and for degenerative conditions. Both groups demonstrated greater cartilage deterioration than nonsurgical knees, controlling for prior knee injury.

AB - OBJECTIVE: To compare the extent of cartilage deterioration in knees with prior meniscal resection related to trauma versus knees with resection related to degenerative disease, and to compare cartilage deterioration in knees with meniscal surgery to knees without meniscal surgery, controlling for prior knee trauma.MATERIALS AND METHODS: In this cross-sectional study, we assessed cartilage deterioration in right knees of Osteoarthritis Initiative participants: (i) with meniscal surgery due to injury (n = 79); (ii) matched control knees with a prior injury but without meniscal surgery (n = 79); (iii) with meniscal surgery but without preceding injury (n = 36); and (iv) matched control knees without meniscal surgery or prior knee injury (n = 36). Cartilage composition was measured using T2 measurements derived using semi-automatic cartilage segmentation of the right. Linear regression analysis was used to compare compartmental values of T2 between groups.RESULTS: Comparing the mean T2 values in surgical cases with and without injury our results did not show significant differences (group i vs. iii, p > 0.05). However, knees with previous meniscal surgery showed significantly (p < 0.001) higher mean T2 values across all compartments (i.e., global T2) when compared to those without meniscal surgery for both knees with a history of trauma (group i vs. ii) and knees without prior trauma (group iii vs. iv). Similar results were obtained when analyzing the compartments separately.CONCLUSIONS: Cartilage deterioration, assessed by T2, is similar in knees undergoing meniscal surgery after trauma and for degenerative conditions. Both groups demonstrated greater cartilage deterioration than nonsurgical knees, controlling for prior knee injury.

KW - Aged

KW - Cartilage Diseases/diagnostic imaging

KW - Cartilage, Articular/diagnostic imaging

KW - Cohort Studies

KW - Cross-Sectional Studies

KW - Female

KW - Humans

KW - Knee Injuries/surgery

KW - Magnetic Resonance Imaging/methods

KW - Male

KW - Meniscectomy

KW - Menisci, Tibial/diagnostic imaging

KW - Middle Aged

KW - Osteoarthritis, Knee/surgery

KW - Postoperative Complications/diagnostic imaging

KW - United States

U2 - 10.1007/s00256-019-03267-0

DO - 10.1007/s00256-019-03267-0

M3 - SCORING: Journal article

C2 - 31289901

VL - 49

SP - 231

EP - 240

JO - SKELETAL RADIOL

JF - SKELETAL RADIOL

SN - 0364-2348

IS - 2

ER -