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Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study

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Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study. / Schmitt, Volker H; Leuschner, Anja; Jünger, Claus; Pinto, Antonio; Hahad, Omar; Schulz, Andreas; Arnold, Natalie; Tröbs, Sven-Oliver; Panova-Noeva, Marina; Keller, Karsten; Zeller, Tanja; Beutel, Manfred; Pfeiffer, Norbert; Strauch, Konstantin; Blankenberg, Stefan; Lackner, Karl J; Prochaska, Jürgen H; Wild, Philipp S; Münzel, Thomas.

In: CLIN RES CARDIOL, Vol. 111, No. 3, 03.2022, p. 272-283.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schmitt, VH, Leuschner, A, Jünger, C, Pinto, A, Hahad, O, Schulz, A, Arnold, N, Tröbs, S-O, Panova-Noeva, M, Keller, K, Zeller, T, Beutel, M, Pfeiffer, N, Strauch, K, Blankenberg, S, Lackner, KJ, Prochaska, JH, Wild, PS & Münzel, T 2022, 'Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study', CLIN RES CARDIOL, vol. 111, no. 3, pp. 272-283. https://doi.org/10.1007/s00392-021-01879-y

APA

Schmitt, V. H., Leuschner, A., Jünger, C., Pinto, A., Hahad, O., Schulz, A., Arnold, N., Tröbs, S-O., Panova-Noeva, M., Keller, K., Zeller, T., Beutel, M., Pfeiffer, N., Strauch, K., Blankenberg, S., Lackner, K. J., Prochaska, J. H., Wild, P. S., & Münzel, T. (2022). Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study. CLIN RES CARDIOL, 111(3), 272-283. https://doi.org/10.1007/s00392-021-01879-y

Vancouver

Schmitt VH, Leuschner A, Jünger C, Pinto A, Hahad O, Schulz A et al. Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study. CLIN RES CARDIOL. 2022 Mar;111(3):272-283. https://doi.org/10.1007/s00392-021-01879-y

Bibtex

@article{f4387d5306af43008c1f427b7729f2f8,
title = "Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study",
abstract = "AIMS: To assess the prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in the general population and to investigate the associated cardiovascular burden and clinical outcome.METHODS AND RESULTS: The study sample comprised 15,010 individuals aged 35-74 years of the population-based Gutenberg Health Study. Subjects were classified into euglycaemia, prediabetes and T2DM according to clinical and metabolic (HbA1c) information. The prevalence of prediabetes was 9.5% (n = 1415) and of T2DM 8.9% (n = 1316). Prediabetes and T2DM showed a significantly increased prevalence ratio (PR) for age, obesity, active smoking, dyslipidemia, and arterial hypertension compared to euglycaemia (for all, P < 0.0001). In a robust Poisson regression analysis, prediabetes was established as an independent predictor of clinically-prevalent cardiovascular disease (PRprediabetes 1.20, 95% CI 1.07-1.35, P = 0.002) and represented as a risk factor for asymptomatic cardiovascular organ damage independent of traditional risk factors (PR 1.04, 95% CI 1.01-1.08, P = 0.025). Prediabetes was associated with a 1.5-fold increased 10-year risk for cardiovascular disease compared to euglycaemia. In Cox regression analysis, prediabetes (HR 2.10, 95% CI 1.76-2.51, P < 0.0001) and T2DM (HR 4.28, 95% CI 3.73-4.92, P < 0.0001) indicated for an increased risk of death. After adjustment for age, sex and traditional cardiovascular risk factors, only T2DM (HR 1.89, 95% CI 1.63-2.20, P < 0.0001) remained independently associated with increased all-cause mortality.CONCLUSION: Besides T2DM, also prediabetes inherits a significant cardiovascular burden, which translates into poor clinical outcome and indicates the need for new concepts regarding the prevention of cardiometabolic disorders.",
author = "Schmitt, {Volker H} and Anja Leuschner and Claus J{\"u}nger and Antonio Pinto and Omar Hahad and Andreas Schulz and Natalie Arnold and Sven-Oliver Tr{\"o}bs and Marina Panova-Noeva and Karsten Keller and Tanja Zeller and Manfred Beutel and Norbert Pfeiffer and Konstantin Strauch and Stefan Blankenberg and Lackner, {Karl J} and Prochaska, {J{\"u}rgen H} and Wild, {Philipp S} and Thomas M{\"u}nzel",
year = "2022",
month = mar,
doi = "10.1007/s00392-021-01879-y",
language = "English",
volume = "111",
pages = "272--283",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "3",

}

RIS

TY - JOUR

T1 - Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study

AU - Schmitt, Volker H

AU - Leuschner, Anja

AU - Jünger, Claus

AU - Pinto, Antonio

AU - Hahad, Omar

AU - Schulz, Andreas

AU - Arnold, Natalie

AU - Tröbs, Sven-Oliver

AU - Panova-Noeva, Marina

AU - Keller, Karsten

AU - Zeller, Tanja

AU - Beutel, Manfred

AU - Pfeiffer, Norbert

AU - Strauch, Konstantin

AU - Blankenberg, Stefan

AU - Lackner, Karl J

AU - Prochaska, Jürgen H

AU - Wild, Philipp S

AU - Münzel, Thomas

PY - 2022/3

Y1 - 2022/3

N2 - AIMS: To assess the prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in the general population and to investigate the associated cardiovascular burden and clinical outcome.METHODS AND RESULTS: The study sample comprised 15,010 individuals aged 35-74 years of the population-based Gutenberg Health Study. Subjects were classified into euglycaemia, prediabetes and T2DM according to clinical and metabolic (HbA1c) information. The prevalence of prediabetes was 9.5% (n = 1415) and of T2DM 8.9% (n = 1316). Prediabetes and T2DM showed a significantly increased prevalence ratio (PR) for age, obesity, active smoking, dyslipidemia, and arterial hypertension compared to euglycaemia (for all, P < 0.0001). In a robust Poisson regression analysis, prediabetes was established as an independent predictor of clinically-prevalent cardiovascular disease (PRprediabetes 1.20, 95% CI 1.07-1.35, P = 0.002) and represented as a risk factor for asymptomatic cardiovascular organ damage independent of traditional risk factors (PR 1.04, 95% CI 1.01-1.08, P = 0.025). Prediabetes was associated with a 1.5-fold increased 10-year risk for cardiovascular disease compared to euglycaemia. In Cox regression analysis, prediabetes (HR 2.10, 95% CI 1.76-2.51, P < 0.0001) and T2DM (HR 4.28, 95% CI 3.73-4.92, P < 0.0001) indicated for an increased risk of death. After adjustment for age, sex and traditional cardiovascular risk factors, only T2DM (HR 1.89, 95% CI 1.63-2.20, P < 0.0001) remained independently associated with increased all-cause mortality.CONCLUSION: Besides T2DM, also prediabetes inherits a significant cardiovascular burden, which translates into poor clinical outcome and indicates the need for new concepts regarding the prevention of cardiometabolic disorders.

AB - AIMS: To assess the prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in the general population and to investigate the associated cardiovascular burden and clinical outcome.METHODS AND RESULTS: The study sample comprised 15,010 individuals aged 35-74 years of the population-based Gutenberg Health Study. Subjects were classified into euglycaemia, prediabetes and T2DM according to clinical and metabolic (HbA1c) information. The prevalence of prediabetes was 9.5% (n = 1415) and of T2DM 8.9% (n = 1316). Prediabetes and T2DM showed a significantly increased prevalence ratio (PR) for age, obesity, active smoking, dyslipidemia, and arterial hypertension compared to euglycaemia (for all, P < 0.0001). In a robust Poisson regression analysis, prediabetes was established as an independent predictor of clinically-prevalent cardiovascular disease (PRprediabetes 1.20, 95% CI 1.07-1.35, P = 0.002) and represented as a risk factor for asymptomatic cardiovascular organ damage independent of traditional risk factors (PR 1.04, 95% CI 1.01-1.08, P = 0.025). Prediabetes was associated with a 1.5-fold increased 10-year risk for cardiovascular disease compared to euglycaemia. In Cox regression analysis, prediabetes (HR 2.10, 95% CI 1.76-2.51, P < 0.0001) and T2DM (HR 4.28, 95% CI 3.73-4.92, P < 0.0001) indicated for an increased risk of death. After adjustment for age, sex and traditional cardiovascular risk factors, only T2DM (HR 1.89, 95% CI 1.63-2.20, P < 0.0001) remained independently associated with increased all-cause mortality.CONCLUSION: Besides T2DM, also prediabetes inherits a significant cardiovascular burden, which translates into poor clinical outcome and indicates the need for new concepts regarding the prevention of cardiometabolic disorders.

U2 - 10.1007/s00392-021-01879-y

DO - 10.1007/s00392-021-01879-y

M3 - SCORING: Journal article

C2 - 34169342

VL - 111

SP - 272

EP - 283

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 3

ER -