Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study
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Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study. / Schmitt, Volker H; Leuschner, Anja; Jünger, Claus; Pinto, Antonio; Hahad, Omar; Schulz, Andreas; Arnold, Natalie; Tröbs, Sven-Oliver; Panova-Noeva, Marina; Keller, Karsten; Zeller, Tanja; Beutel, Manfred; Pfeiffer, Norbert; Strauch, Konstantin; Blankenberg, Stefan; Lackner, Karl J; Prochaska, Jürgen H; Wild, Philipp S; Münzel, Thomas.
in: CLIN RES CARDIOL, Jahrgang 111, Nr. 3, 03.2022, S. 272-283.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study
AU - Schmitt, Volker H
AU - Leuschner, Anja
AU - Jünger, Claus
AU - Pinto, Antonio
AU - Hahad, Omar
AU - Schulz, Andreas
AU - Arnold, Natalie
AU - Tröbs, Sven-Oliver
AU - Panova-Noeva, Marina
AU - Keller, Karsten
AU - Zeller, Tanja
AU - Beutel, Manfred
AU - Pfeiffer, Norbert
AU - Strauch, Konstantin
AU - Blankenberg, Stefan
AU - Lackner, Karl J
AU - Prochaska, Jürgen H
AU - Wild, Philipp S
AU - Münzel, Thomas
PY - 2022/3
Y1 - 2022/3
N2 - AIMS: To assess the prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in the general population and to investigate the associated cardiovascular burden and clinical outcome.METHODS AND RESULTS: The study sample comprised 15,010 individuals aged 35-74 years of the population-based Gutenberg Health Study. Subjects were classified into euglycaemia, prediabetes and T2DM according to clinical and metabolic (HbA1c) information. The prevalence of prediabetes was 9.5% (n = 1415) and of T2DM 8.9% (n = 1316). Prediabetes and T2DM showed a significantly increased prevalence ratio (PR) for age, obesity, active smoking, dyslipidemia, and arterial hypertension compared to euglycaemia (for all, P < 0.0001). In a robust Poisson regression analysis, prediabetes was established as an independent predictor of clinically-prevalent cardiovascular disease (PRprediabetes 1.20, 95% CI 1.07-1.35, P = 0.002) and represented as a risk factor for asymptomatic cardiovascular organ damage independent of traditional risk factors (PR 1.04, 95% CI 1.01-1.08, P = 0.025). Prediabetes was associated with a 1.5-fold increased 10-year risk for cardiovascular disease compared to euglycaemia. In Cox regression analysis, prediabetes (HR 2.10, 95% CI 1.76-2.51, P < 0.0001) and T2DM (HR 4.28, 95% CI 3.73-4.92, P < 0.0001) indicated for an increased risk of death. After adjustment for age, sex and traditional cardiovascular risk factors, only T2DM (HR 1.89, 95% CI 1.63-2.20, P < 0.0001) remained independently associated with increased all-cause mortality.CONCLUSION: Besides T2DM, also prediabetes inherits a significant cardiovascular burden, which translates into poor clinical outcome and indicates the need for new concepts regarding the prevention of cardiometabolic disorders.
AB - AIMS: To assess the prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in the general population and to investigate the associated cardiovascular burden and clinical outcome.METHODS AND RESULTS: The study sample comprised 15,010 individuals aged 35-74 years of the population-based Gutenberg Health Study. Subjects were classified into euglycaemia, prediabetes and T2DM according to clinical and metabolic (HbA1c) information. The prevalence of prediabetes was 9.5% (n = 1415) and of T2DM 8.9% (n = 1316). Prediabetes and T2DM showed a significantly increased prevalence ratio (PR) for age, obesity, active smoking, dyslipidemia, and arterial hypertension compared to euglycaemia (for all, P < 0.0001). In a robust Poisson regression analysis, prediabetes was established as an independent predictor of clinically-prevalent cardiovascular disease (PRprediabetes 1.20, 95% CI 1.07-1.35, P = 0.002) and represented as a risk factor for asymptomatic cardiovascular organ damage independent of traditional risk factors (PR 1.04, 95% CI 1.01-1.08, P = 0.025). Prediabetes was associated with a 1.5-fold increased 10-year risk for cardiovascular disease compared to euglycaemia. In Cox regression analysis, prediabetes (HR 2.10, 95% CI 1.76-2.51, P < 0.0001) and T2DM (HR 4.28, 95% CI 3.73-4.92, P < 0.0001) indicated for an increased risk of death. After adjustment for age, sex and traditional cardiovascular risk factors, only T2DM (HR 1.89, 95% CI 1.63-2.20, P < 0.0001) remained independently associated with increased all-cause mortality.CONCLUSION: Besides T2DM, also prediabetes inherits a significant cardiovascular burden, which translates into poor clinical outcome and indicates the need for new concepts regarding the prevention of cardiometabolic disorders.
U2 - 10.1007/s00392-021-01879-y
DO - 10.1007/s00392-021-01879-y
M3 - SCORING: Journal article
C2 - 34169342
VL - 111
SP - 272
EP - 283
JO - CLIN RES CARDIOL
JF - CLIN RES CARDIOL
SN - 1861-0684
IS - 3
ER -