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Cardiac Magnetic Resonance Evaluation of the Extent of Myocardial Injury in Patients with Inferior ST Elevation Myocardial Infarction and Concomitant ST Depression in Leads V1-V3: Analysis from the MITOCARE Study

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Cardiac Magnetic Resonance Evaluation of the Extent of Myocardial Injury in Patients with Inferior ST Elevation Myocardial Infarction and Concomitant ST Depression in Leads V1-V3: Analysis from the MITOCARE Study. / Jia, Xiaoming; Heiberg, Einar; Sejersten Ripa, Maria; Engblom, Henrik; Carlsson, Marcus; Halvorsen, Sigrun; Arheden, Håkan; Atar, Dan; Clemmensen, Peter; Birnbaum, Yochai.

In: CARDIOLOGY, Vol. 140, No. 3, 2018, p. 178-185.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jia, X, Heiberg, E, Sejersten Ripa, M, Engblom, H, Carlsson, M, Halvorsen, S, Arheden, H, Atar, D, Clemmensen, P & Birnbaum, Y 2018, 'Cardiac Magnetic Resonance Evaluation of the Extent of Myocardial Injury in Patients with Inferior ST Elevation Myocardial Infarction and Concomitant ST Depression in Leads V1-V3: Analysis from the MITOCARE Study', CARDIOLOGY, vol. 140, no. 3, pp. 178-185. https://doi.org/10.1159/000491745

APA

Jia, X., Heiberg, E., Sejersten Ripa, M., Engblom, H., Carlsson, M., Halvorsen, S., Arheden, H., Atar, D., Clemmensen, P., & Birnbaum, Y. (2018). Cardiac Magnetic Resonance Evaluation of the Extent of Myocardial Injury in Patients with Inferior ST Elevation Myocardial Infarction and Concomitant ST Depression in Leads V1-V3: Analysis from the MITOCARE Study. CARDIOLOGY, 140(3), 178-185. https://doi.org/10.1159/000491745

Vancouver

Jia X, Heiberg E, Sejersten Ripa M, Engblom H, Carlsson M, Halvorsen S et al. Cardiac Magnetic Resonance Evaluation of the Extent of Myocardial Injury in Patients with Inferior ST Elevation Myocardial Infarction and Concomitant ST Depression in Leads V1-V3: Analysis from the MITOCARE Study. CARDIOLOGY. 2018;140(3):178-185. https://doi.org/10.1159/000491745

Bibtex

@article{666979249f394e9f80f756d2f18141bc,
title = "Cardiac Magnetic Resonance Evaluation of the Extent of Myocardial Injury in Patients with Inferior ST Elevation Myocardial Infarction and Concomitant ST Depression in Leads V1-V3: Analysis from the MITOCARE Study",
abstract = "The aim of our study was to examine the pathophysiology of ST depression (STD) in leads V1-V3 in the setting of inferior ST elevation myocardial infarction (iSTEMI) through the perspective of cardiac magnetic resonance (CMR).METHODS: Differences in myocardial area at risk (MaR), infarct size, ejection fraction and myocardial segment involvement by CMR were compared in MITOCARE trial patients with first iSTEMI with ST elevation (STE), STD or no ST changes (NST) in V1-V3. The frontal plane projection of the inferior wall MaR in relationship to the anterior/posterior chest wall was calculated and compared between groups.RESULTS: Fifty-six patients were included. Patients with STD (n = 38) and STE (n = 5) in V1-V3 had significantly larger mean MaR compared to NST (n = 13; 32 ± 7%LV, 36 ± 10%LV and 26 ± 6%LV, respectively; p = 0.01). STD in leads V1-V3 was associated with more apical inferior and mid inferoseptal involvement and had a larger mean frontal plane projection of MaR compared with NST (24 ± 6%LV vs. 20 ± 6%LV, p = 0.04).CONCLUSION: STD in V1-V3 in iSTEMI is associated with larger MaR, more extension into the inferoseptal segments and likely results from greater frontal plane projection of the MaR, leading to reciprocal changes on the electrocardiogram.",
keywords = "Aged, Clinical Trials, Phase II as Topic, Electrocardiography, Female, Heart Rate, Humans, Inferior Wall Myocardial Infarction/diagnostic imaging, Magnetic Resonance Imaging, Male, Middle Aged, Myocardium/pathology, Randomized Controlled Trials as Topic, ST Elevation Myocardial Infarction/diagnostic imaging",
author = "Xiaoming Jia and Einar Heiberg and {Sejersten Ripa}, Maria and Henrik Engblom and Marcus Carlsson and Sigrun Halvorsen and H{\aa}kan Arheden and Dan Atar and Peter Clemmensen and Yochai Birnbaum",
note = "{\textcopyright} 2018 S. Karger AG, Basel.",
year = "2018",
doi = "10.1159/000491745",
language = "English",
volume = "140",
pages = "178--185",
journal = "CARDIOLOGY",
issn = "0008-6312",
publisher = "S. Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - Cardiac Magnetic Resonance Evaluation of the Extent of Myocardial Injury in Patients with Inferior ST Elevation Myocardial Infarction and Concomitant ST Depression in Leads V1-V3: Analysis from the MITOCARE Study

AU - Jia, Xiaoming

AU - Heiberg, Einar

AU - Sejersten Ripa, Maria

AU - Engblom, Henrik

AU - Carlsson, Marcus

AU - Halvorsen, Sigrun

AU - Arheden, Håkan

AU - Atar, Dan

AU - Clemmensen, Peter

AU - Birnbaum, Yochai

N1 - © 2018 S. Karger AG, Basel.

PY - 2018

Y1 - 2018

N2 - The aim of our study was to examine the pathophysiology of ST depression (STD) in leads V1-V3 in the setting of inferior ST elevation myocardial infarction (iSTEMI) through the perspective of cardiac magnetic resonance (CMR).METHODS: Differences in myocardial area at risk (MaR), infarct size, ejection fraction and myocardial segment involvement by CMR were compared in MITOCARE trial patients with first iSTEMI with ST elevation (STE), STD or no ST changes (NST) in V1-V3. The frontal plane projection of the inferior wall MaR in relationship to the anterior/posterior chest wall was calculated and compared between groups.RESULTS: Fifty-six patients were included. Patients with STD (n = 38) and STE (n = 5) in V1-V3 had significantly larger mean MaR compared to NST (n = 13; 32 ± 7%LV, 36 ± 10%LV and 26 ± 6%LV, respectively; p = 0.01). STD in leads V1-V3 was associated with more apical inferior and mid inferoseptal involvement and had a larger mean frontal plane projection of MaR compared with NST (24 ± 6%LV vs. 20 ± 6%LV, p = 0.04).CONCLUSION: STD in V1-V3 in iSTEMI is associated with larger MaR, more extension into the inferoseptal segments and likely results from greater frontal plane projection of the MaR, leading to reciprocal changes on the electrocardiogram.

AB - The aim of our study was to examine the pathophysiology of ST depression (STD) in leads V1-V3 in the setting of inferior ST elevation myocardial infarction (iSTEMI) through the perspective of cardiac magnetic resonance (CMR).METHODS: Differences in myocardial area at risk (MaR), infarct size, ejection fraction and myocardial segment involvement by CMR were compared in MITOCARE trial patients with first iSTEMI with ST elevation (STE), STD or no ST changes (NST) in V1-V3. The frontal plane projection of the inferior wall MaR in relationship to the anterior/posterior chest wall was calculated and compared between groups.RESULTS: Fifty-six patients were included. Patients with STD (n = 38) and STE (n = 5) in V1-V3 had significantly larger mean MaR compared to NST (n = 13; 32 ± 7%LV, 36 ± 10%LV and 26 ± 6%LV, respectively; p = 0.01). STD in leads V1-V3 was associated with more apical inferior and mid inferoseptal involvement and had a larger mean frontal plane projection of MaR compared with NST (24 ± 6%LV vs. 20 ± 6%LV, p = 0.04).CONCLUSION: STD in V1-V3 in iSTEMI is associated with larger MaR, more extension into the inferoseptal segments and likely results from greater frontal plane projection of the MaR, leading to reciprocal changes on the electrocardiogram.

KW - Aged

KW - Clinical Trials, Phase II as Topic

KW - Electrocardiography

KW - Female

KW - Heart Rate

KW - Humans

KW - Inferior Wall Myocardial Infarction/diagnostic imaging

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Myocardium/pathology

KW - Randomized Controlled Trials as Topic

KW - ST Elevation Myocardial Infarction/diagnostic imaging

U2 - 10.1159/000491745

DO - 10.1159/000491745

M3 - SCORING: Journal article

C2 - 30099440

VL - 140

SP - 178

EP - 185

JO - CARDIOLOGY

JF - CARDIOLOGY

SN - 0008-6312

IS - 3

ER -