Cardiac Magnetic Resonance Evaluation of the Extent of Myocardial Injury in Patients with Inferior ST Elevation Myocardial Infarction and Concomitant ST Depression in Leads V1-V3: Analysis from the MITOCARE Study
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Cardiac Magnetic Resonance Evaluation of the Extent of Myocardial Injury in Patients with Inferior ST Elevation Myocardial Infarction and Concomitant ST Depression in Leads V1-V3: Analysis from the MITOCARE Study. / Jia, Xiaoming; Heiberg, Einar; Sejersten Ripa, Maria; Engblom, Henrik; Carlsson, Marcus; Halvorsen, Sigrun; Arheden, Håkan; Atar, Dan; Clemmensen, Peter; Birnbaum, Yochai.
in: CARDIOLOGY, Jahrgang 140, Nr. 3, 2018, S. 178-185.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cardiac Magnetic Resonance Evaluation of the Extent of Myocardial Injury in Patients with Inferior ST Elevation Myocardial Infarction and Concomitant ST Depression in Leads V1-V3: Analysis from the MITOCARE Study
AU - Jia, Xiaoming
AU - Heiberg, Einar
AU - Sejersten Ripa, Maria
AU - Engblom, Henrik
AU - Carlsson, Marcus
AU - Halvorsen, Sigrun
AU - Arheden, Håkan
AU - Atar, Dan
AU - Clemmensen, Peter
AU - Birnbaum, Yochai
N1 - © 2018 S. Karger AG, Basel.
PY - 2018
Y1 - 2018
N2 - The aim of our study was to examine the pathophysiology of ST depression (STD) in leads V1-V3 in the setting of inferior ST elevation myocardial infarction (iSTEMI) through the perspective of cardiac magnetic resonance (CMR).METHODS: Differences in myocardial area at risk (MaR), infarct size, ejection fraction and myocardial segment involvement by CMR were compared in MITOCARE trial patients with first iSTEMI with ST elevation (STE), STD or no ST changes (NST) in V1-V3. The frontal plane projection of the inferior wall MaR in relationship to the anterior/posterior chest wall was calculated and compared between groups.RESULTS: Fifty-six patients were included. Patients with STD (n = 38) and STE (n = 5) in V1-V3 had significantly larger mean MaR compared to NST (n = 13; 32 ± 7%LV, 36 ± 10%LV and 26 ± 6%LV, respectively; p = 0.01). STD in leads V1-V3 was associated with more apical inferior and mid inferoseptal involvement and had a larger mean frontal plane projection of MaR compared with NST (24 ± 6%LV vs. 20 ± 6%LV, p = 0.04).CONCLUSION: STD in V1-V3 in iSTEMI is associated with larger MaR, more extension into the inferoseptal segments and likely results from greater frontal plane projection of the MaR, leading to reciprocal changes on the electrocardiogram.
AB - The aim of our study was to examine the pathophysiology of ST depression (STD) in leads V1-V3 in the setting of inferior ST elevation myocardial infarction (iSTEMI) through the perspective of cardiac magnetic resonance (CMR).METHODS: Differences in myocardial area at risk (MaR), infarct size, ejection fraction and myocardial segment involvement by CMR were compared in MITOCARE trial patients with first iSTEMI with ST elevation (STE), STD or no ST changes (NST) in V1-V3. The frontal plane projection of the inferior wall MaR in relationship to the anterior/posterior chest wall was calculated and compared between groups.RESULTS: Fifty-six patients were included. Patients with STD (n = 38) and STE (n = 5) in V1-V3 had significantly larger mean MaR compared to NST (n = 13; 32 ± 7%LV, 36 ± 10%LV and 26 ± 6%LV, respectively; p = 0.01). STD in leads V1-V3 was associated with more apical inferior and mid inferoseptal involvement and had a larger mean frontal plane projection of MaR compared with NST (24 ± 6%LV vs. 20 ± 6%LV, p = 0.04).CONCLUSION: STD in V1-V3 in iSTEMI is associated with larger MaR, more extension into the inferoseptal segments and likely results from greater frontal plane projection of the MaR, leading to reciprocal changes on the electrocardiogram.
KW - Aged
KW - Clinical Trials, Phase II as Topic
KW - Electrocardiography
KW - Female
KW - Heart Rate
KW - Humans
KW - Inferior Wall Myocardial Infarction/diagnostic imaging
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Myocardium/pathology
KW - Randomized Controlled Trials as Topic
KW - ST Elevation Myocardial Infarction/diagnostic imaging
U2 - 10.1159/000491745
DO - 10.1159/000491745
M3 - SCORING: Journal article
C2 - 30099440
VL - 140
SP - 178
EP - 185
JO - CARDIOLOGY
JF - CARDIOLOGY
SN - 0008-6312
IS - 3
ER -