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Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium

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Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium. / Engel, Nils W; Neumann, Julia E; Ahlfeld, Julia; Wefers, Annika K; Merk, Daniel J; Ohli, Jasmin; Schüller, Ulrich.

In: PLOS ONE, Vol. 11, No. 11, 2016, p. e0166690.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Engel, NW, Neumann, JE, Ahlfeld, J, Wefers, AK, Merk, DJ, Ohli, J & Schüller, U 2016, 'Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium', PLOS ONE, vol. 11, no. 11, pp. e0166690. https://doi.org/10.1371/journal.pone.0166690

APA

Engel, N. W., Neumann, J. E., Ahlfeld, J., Wefers, A. K., Merk, D. J., Ohli, J., & Schüller, U. (2016). Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium. PLOS ONE, 11(11), e0166690. https://doi.org/10.1371/journal.pone.0166690

Vancouver

Engel NW, Neumann JE, Ahlfeld J, Wefers AK, Merk DJ, Ohli J et al. Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium. PLOS ONE. 2016;11(11):e0166690. https://doi.org/10.1371/journal.pone.0166690

Bibtex

@article{5d4e30026ce84b12a2336b1f61cd70c5,
title = "Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium",
abstract = "Canonical Wnt signaling is known to promote proliferation of olfactory stem cells. In order to investigate the effects of a constitutive activation of Wnt signaling in Sox2-positive precursor cells of the olfactory epithelium, we used transgenic mice that allowed an inducible deletion of exon 3 of the Ctnnb1 gene, which is responsible for the phosphorylation and degradation of Ctnnb1 protein. After induction of aberrant Wnt activation by Ctnnb1 deletion at embryonic day 14, such mice developed tumor-like lesions in upper parts of the nasal cavity. We still observed areas of epithelial hyperplasia within the olfactory epithelium following early postnatal Wnt activation, but the olfactory epithelial architecture remained unaffected in most parts when Wnt was activated at postnatal day 21 or later. In summary, our results suggest an age-dependent tumorigenic potential of aberrant Wnt signaling in the olfactory epithelium of mice.",
author = "Engel, {Nils W} and Neumann, {Julia E} and Julia Ahlfeld and Wefers, {Annika K} and Merk, {Daniel J} and Jasmin Ohli and Ulrich Sch{\"u}ller",
year = "2016",
doi = "10.1371/journal.pone.0166690",
language = "English",
volume = "11",
pages = "e0166690",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

RIS

TY - JOUR

T1 - Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium

AU - Engel, Nils W

AU - Neumann, Julia E

AU - Ahlfeld, Julia

AU - Wefers, Annika K

AU - Merk, Daniel J

AU - Ohli, Jasmin

AU - Schüller, Ulrich

PY - 2016

Y1 - 2016

N2 - Canonical Wnt signaling is known to promote proliferation of olfactory stem cells. In order to investigate the effects of a constitutive activation of Wnt signaling in Sox2-positive precursor cells of the olfactory epithelium, we used transgenic mice that allowed an inducible deletion of exon 3 of the Ctnnb1 gene, which is responsible for the phosphorylation and degradation of Ctnnb1 protein. After induction of aberrant Wnt activation by Ctnnb1 deletion at embryonic day 14, such mice developed tumor-like lesions in upper parts of the nasal cavity. We still observed areas of epithelial hyperplasia within the olfactory epithelium following early postnatal Wnt activation, but the olfactory epithelial architecture remained unaffected in most parts when Wnt was activated at postnatal day 21 or later. In summary, our results suggest an age-dependent tumorigenic potential of aberrant Wnt signaling in the olfactory epithelium of mice.

AB - Canonical Wnt signaling is known to promote proliferation of olfactory stem cells. In order to investigate the effects of a constitutive activation of Wnt signaling in Sox2-positive precursor cells of the olfactory epithelium, we used transgenic mice that allowed an inducible deletion of exon 3 of the Ctnnb1 gene, which is responsible for the phosphorylation and degradation of Ctnnb1 protein. After induction of aberrant Wnt activation by Ctnnb1 deletion at embryonic day 14, such mice developed tumor-like lesions in upper parts of the nasal cavity. We still observed areas of epithelial hyperplasia within the olfactory epithelium following early postnatal Wnt activation, but the olfactory epithelial architecture remained unaffected in most parts when Wnt was activated at postnatal day 21 or later. In summary, our results suggest an age-dependent tumorigenic potential of aberrant Wnt signaling in the olfactory epithelium of mice.

U2 - 10.1371/journal.pone.0166690

DO - 10.1371/journal.pone.0166690

M3 - SCORING: Journal article

C2 - 27902722

VL - 11

SP - e0166690

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 11

ER -