Cancer Stem Cells and Radioresistance: DNA Repair and Beyond
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Cancer Stem Cells and Radioresistance: DNA Repair and Beyond. / Meyer, Felix; Borgmann, Kerstin; Schulz, Alexander; Dubrovska, Anna.
In: CANCERS, Vol. 2019, No. 11, 11060862, 21.06.2019, p. 1-20.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Cancer Stem Cells and Radioresistance: DNA Repair and Beyond
AU - Meyer, Felix
AU - Borgmann, Kerstin
AU - Schulz, Alexander
AU - Dubrovska, Anna
PY - 2019/6/21
Y1 - 2019/6/21
N2 - The current preclinical and clinical findings demonstrate that, in addition to the conventionalclinical and pathological indicators that have a prognostic value in radiation oncology, the number of cancer stem cells (CSCs) and their inherentradioresistance are important parameters for local control after radiotherapy. In this review, we discuss the molecularmechanisms of CSC radioresistance attributable to DNA repair mechanisms and the development of CSC-targeted therapies for Tumor radiosensitization. We also discuss the current challenges in preclinical and translational CSC researchincluding the high inter- and intratumoral heterogeneity, plasticity of CSCs, and microenvironmentstimulated tumor cell reprogramming.
AB - The current preclinical and clinical findings demonstrate that, in addition to the conventionalclinical and pathological indicators that have a prognostic value in radiation oncology, the number of cancer stem cells (CSCs) and their inherentradioresistance are important parameters for local control after radiotherapy. In this review, we discuss the molecularmechanisms of CSC radioresistance attributable to DNA repair mechanisms and the development of CSC-targeted therapies for Tumor radiosensitization. We also discuss the current challenges in preclinical and translational CSC researchincluding the high inter- and intratumoral heterogeneity, plasticity of CSCs, and microenvironmentstimulated tumor cell reprogramming.
M3 - SCORING: Review
VL - 2019
SP - 1
EP - 20
JO - CANCERS
JF - CANCERS
SN - 2072-6694
IS - 11
M1 - 11060862
ER -