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Cancer Stem Cells and Radioresistance: DNA Repair and Beyond

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Cancer Stem Cells and Radioresistance: DNA Repair and Beyond. / Meyer, Felix; Borgmann, Kerstin; Schulz, Alexander; Dubrovska, Anna.

in: CANCERS, Jahrgang 2019, Nr. 11, 11060862, 21.06.2019, S. 1-20.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Meyer, F, Borgmann, K, Schulz, A & Dubrovska, A 2019, 'Cancer Stem Cells and Radioresistance: DNA Repair and Beyond', CANCERS, Jg. 2019, Nr. 11, 11060862, S. 1-20.

APA

Meyer, F., Borgmann, K., Schulz, A., & Dubrovska, A. (2019). Cancer Stem Cells and Radioresistance: DNA Repair and Beyond. CANCERS, 2019(11), 1-20. [11060862].

Vancouver

Meyer F, Borgmann K, Schulz A, Dubrovska A. Cancer Stem Cells and Radioresistance: DNA Repair and Beyond. CANCERS. 2019 Jun 21;2019(11):1-20. 11060862.

Bibtex

@article{23640400735a469a8bb631b3fdd5f9b7,
title = "Cancer Stem Cells and Radioresistance: DNA Repair and Beyond",
abstract = "The current preclinical and clinical findings demonstrate that, in addition to the conventionalclinical and pathological indicators that have a prognostic value in radiation oncology, the number of cancer stem cells (CSCs) and their inherentradioresistance are important parameters for local control after radiotherapy. In this review, we discuss the molecularmechanisms of CSC radioresistance attributable to DNA repair mechanisms and the development of CSC-targeted therapies for Tumor radiosensitization. We also discuss the current challenges in preclinical and translational CSC researchincluding the high inter- and intratumoral heterogeneity, plasticity of CSCs, and microenvironmentstimulated tumor cell reprogramming.",
author = "Felix Meyer and Kerstin Borgmann and Alexander Schulz and Anna Dubrovska",
year = "2019",
month = jun,
day = "21",
language = "Deutsch",
volume = "2019",
pages = "1--20",
journal = "CANCERS",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "11",

}

RIS

TY - JOUR

T1 - Cancer Stem Cells and Radioresistance: DNA Repair and Beyond

AU - Meyer, Felix

AU - Borgmann, Kerstin

AU - Schulz, Alexander

AU - Dubrovska, Anna

PY - 2019/6/21

Y1 - 2019/6/21

N2 - The current preclinical and clinical findings demonstrate that, in addition to the conventionalclinical and pathological indicators that have a prognostic value in radiation oncology, the number of cancer stem cells (CSCs) and their inherentradioresistance are important parameters for local control after radiotherapy. In this review, we discuss the molecularmechanisms of CSC radioresistance attributable to DNA repair mechanisms and the development of CSC-targeted therapies for Tumor radiosensitization. We also discuss the current challenges in preclinical and translational CSC researchincluding the high inter- and intratumoral heterogeneity, plasticity of CSCs, and microenvironmentstimulated tumor cell reprogramming.

AB - The current preclinical and clinical findings demonstrate that, in addition to the conventionalclinical and pathological indicators that have a prognostic value in radiation oncology, the number of cancer stem cells (CSCs) and their inherentradioresistance are important parameters for local control after radiotherapy. In this review, we discuss the molecularmechanisms of CSC radioresistance attributable to DNA repair mechanisms and the development of CSC-targeted therapies for Tumor radiosensitization. We also discuss the current challenges in preclinical and translational CSC researchincluding the high inter- and intratumoral heterogeneity, plasticity of CSCs, and microenvironmentstimulated tumor cell reprogramming.

M3 - SCORING: Review

VL - 2019

SP - 1

EP - 20

JO - CANCERS

JF - CANCERS

SN - 2072-6694

IS - 11

M1 - 11060862

ER -