Cancer incidence among workers occupationally exposed to dinitrotoluene in the copper mining industry
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Cancer incidence among workers occupationally exposed to dinitrotoluene in the copper mining industry. / Seidler, Andreas; Brüning, Thomas; Taeger, Dirk; Möhner, Matthias; Gawrych, Katarzyna; Bergmann, Annekatrin; Haerting, Johannes; Bolt, Hermann Maximilian; Straif, Kurt; Harth, Volker.
In: INT ARCH OCC ENV HEA, Vol. 87, No. 2, 01.02.2014, p. 117-24.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Cancer incidence among workers occupationally exposed to dinitrotoluene in the copper mining industry
AU - Seidler, Andreas
AU - Brüning, Thomas
AU - Taeger, Dirk
AU - Möhner, Matthias
AU - Gawrych, Katarzyna
AU - Bergmann, Annekatrin
AU - Haerting, Johannes
AU - Bolt, Hermann Maximilian
AU - Straif, Kurt
AU - Harth, Volker
PY - 2014/2/1
Y1 - 2014/2/1
N2 - PURPOSE: Epidemiological and toxicological studies point to a potential carcinogenic effect of dinitrotoluene (DNT), particularly with respect to renal and urothelial cancer.METHODS: The cohort comprised all men born between 1920 and 1974 (n = 16,441) who were gainfully employed between 1953 and 1990 in one of two underground copper mines in Mansfeld, Saxony-Anhalt, former German Democratic Republic, and who were followed up for cancer incidence, 1961-2005. Incident cancer cases were identified by record linkage with the Common Cancer Registry of the New Laender. Standardized incidence ratios (SIR) were calculated with the general population of Saxony-Anhalt as the reference.RESULTS: Standardized incidence ratios for all cancers were not significantly elevated in the cohort (SIR = 1.04; 95 % confidence intervals (CI) 0.96-1.14). We found an increase in lung cancer (SIR = 1.29; 1.13-1.46), but not in kidney cancer (SIR = 1.01; 95 % CI 0.79-1.27) or bladder cancer (SIR = 1.04; 95 % CI 0.82-1.30). Standardized incidence ratios stratified by duration of employment with DNT exposure indicated moderately increased risks for kidney and bladder cancer in cohort members with longer exposure.CONCLUSIONS: The SIR analysis of workers in the copper mining industry in comparison with the general population of Saxony-Anhalt overall did not indicate increased risks for renal or bladder cancer. However, results by years of exposure to DNT suggested weakly increased risks for outcomes of a priori interest, bladder and kidney cancer. A subsequent case-cohort analysis including expert assessment of DNT exposure and identification of additional cancer cases from a network of pathology institutes will provide further insight into a potential etiologic role of DNT in renal and urothelial cancer.
AB - PURPOSE: Epidemiological and toxicological studies point to a potential carcinogenic effect of dinitrotoluene (DNT), particularly with respect to renal and urothelial cancer.METHODS: The cohort comprised all men born between 1920 and 1974 (n = 16,441) who were gainfully employed between 1953 and 1990 in one of two underground copper mines in Mansfeld, Saxony-Anhalt, former German Democratic Republic, and who were followed up for cancer incidence, 1961-2005. Incident cancer cases were identified by record linkage with the Common Cancer Registry of the New Laender. Standardized incidence ratios (SIR) were calculated with the general population of Saxony-Anhalt as the reference.RESULTS: Standardized incidence ratios for all cancers were not significantly elevated in the cohort (SIR = 1.04; 95 % confidence intervals (CI) 0.96-1.14). We found an increase in lung cancer (SIR = 1.29; 1.13-1.46), but not in kidney cancer (SIR = 1.01; 95 % CI 0.79-1.27) or bladder cancer (SIR = 1.04; 95 % CI 0.82-1.30). Standardized incidence ratios stratified by duration of employment with DNT exposure indicated moderately increased risks for kidney and bladder cancer in cohort members with longer exposure.CONCLUSIONS: The SIR analysis of workers in the copper mining industry in comparison with the general population of Saxony-Anhalt overall did not indicate increased risks for renal or bladder cancer. However, results by years of exposure to DNT suggested weakly increased risks for outcomes of a priori interest, bladder and kidney cancer. A subsequent case-cohort analysis including expert assessment of DNT exposure and identification of additional cancer cases from a network of pathology institutes will provide further insight into a potential etiologic role of DNT in renal and urothelial cancer.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Air Pollutants, Occupational
KW - Carcinogens
KW - Cohort Studies
KW - Copper
KW - Dinitrobenzenes
KW - Germany
KW - Humans
KW - Incidence
KW - Kidney Neoplasms
KW - Male
KW - Middle Aged
KW - Mining
KW - Neoplasms
KW - Occupational Diseases
KW - Occupational Exposure
KW - Urinary Bladder Neoplasms
U2 - 10.1007/s00420-012-0842-9
DO - 10.1007/s00420-012-0842-9
M3 - SCORING: Journal article
C2 - 23274286
VL - 87
SP - 117
EP - 124
JO - INT ARCH OCC ENV HEA
JF - INT ARCH OCC ENV HEA
SN - 0340-0131
IS - 2
ER -