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Cancer incidence among workers occupationally exposed to dinitrotoluene in the copper mining industry

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Cancer incidence among workers occupationally exposed to dinitrotoluene in the copper mining industry. / Seidler, Andreas; Brüning, Thomas; Taeger, Dirk; Möhner, Matthias; Gawrych, Katarzyna; Bergmann, Annekatrin; Haerting, Johannes; Bolt, Hermann Maximilian; Straif, Kurt; Harth, Volker.

in: INT ARCH OCC ENV HEA, Jahrgang 87, Nr. 2, 01.02.2014, S. 117-24.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Seidler, A, Brüning, T, Taeger, D, Möhner, M, Gawrych, K, Bergmann, A, Haerting, J, Bolt, HM, Straif, K & Harth, V 2014, 'Cancer incidence among workers occupationally exposed to dinitrotoluene in the copper mining industry', INT ARCH OCC ENV HEA, Jg. 87, Nr. 2, S. 117-24. https://doi.org/10.1007/s00420-012-0842-9

APA

Seidler, A., Brüning, T., Taeger, D., Möhner, M., Gawrych, K., Bergmann, A., Haerting, J., Bolt, H. M., Straif, K., & Harth, V. (2014). Cancer incidence among workers occupationally exposed to dinitrotoluene in the copper mining industry. INT ARCH OCC ENV HEA, 87(2), 117-24. https://doi.org/10.1007/s00420-012-0842-9

Vancouver

Seidler A, Brüning T, Taeger D, Möhner M, Gawrych K, Bergmann A et al. Cancer incidence among workers occupationally exposed to dinitrotoluene in the copper mining industry. INT ARCH OCC ENV HEA. 2014 Feb 1;87(2):117-24. https://doi.org/10.1007/s00420-012-0842-9

Bibtex

@article{7c0516217a39483e8107f6b6dfc99815,
title = "Cancer incidence among workers occupationally exposed to dinitrotoluene in the copper mining industry",
abstract = "PURPOSE: Epidemiological and toxicological studies point to a potential carcinogenic effect of dinitrotoluene (DNT), particularly with respect to renal and urothelial cancer.METHODS: The cohort comprised all men born between 1920 and 1974 (n = 16,441) who were gainfully employed between 1953 and 1990 in one of two underground copper mines in Mansfeld, Saxony-Anhalt, former German Democratic Republic, and who were followed up for cancer incidence, 1961-2005. Incident cancer cases were identified by record linkage with the Common Cancer Registry of the New Laender. Standardized incidence ratios (SIR) were calculated with the general population of Saxony-Anhalt as the reference.RESULTS: Standardized incidence ratios for all cancers were not significantly elevated in the cohort (SIR = 1.04; 95 % confidence intervals (CI) 0.96-1.14). We found an increase in lung cancer (SIR = 1.29; 1.13-1.46), but not in kidney cancer (SIR = 1.01; 95 % CI 0.79-1.27) or bladder cancer (SIR = 1.04; 95 % CI 0.82-1.30). Standardized incidence ratios stratified by duration of employment with DNT exposure indicated moderately increased risks for kidney and bladder cancer in cohort members with longer exposure.CONCLUSIONS: The SIR analysis of workers in the copper mining industry in comparison with the general population of Saxony-Anhalt overall did not indicate increased risks for renal or bladder cancer. However, results by years of exposure to DNT suggested weakly increased risks for outcomes of a priori interest, bladder and kidney cancer. A subsequent case-cohort analysis including expert assessment of DNT exposure and identification of additional cancer cases from a network of pathology institutes will provide further insight into a potential etiologic role of DNT in renal and urothelial cancer.",
keywords = "Adult, Aged, Aged, 80 and over, Air Pollutants, Occupational, Carcinogens, Cohort Studies, Copper, Dinitrobenzenes, Germany, Humans, Incidence, Kidney Neoplasms, Male, Middle Aged, Mining, Neoplasms, Occupational Diseases, Occupational Exposure, Urinary Bladder Neoplasms",
author = "Andreas Seidler and Thomas Br{\"u}ning and Dirk Taeger and Matthias M{\"o}hner and Katarzyna Gawrych and Annekatrin Bergmann and Johannes Haerting and Bolt, {Hermann Maximilian} and Kurt Straif and Volker Harth",
year = "2014",
month = feb,
day = "1",
doi = "10.1007/s00420-012-0842-9",
language = "English",
volume = "87",
pages = "117--24",
journal = "INT ARCH OCC ENV HEA",
issn = "0340-0131",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Cancer incidence among workers occupationally exposed to dinitrotoluene in the copper mining industry

AU - Seidler, Andreas

AU - Brüning, Thomas

AU - Taeger, Dirk

AU - Möhner, Matthias

AU - Gawrych, Katarzyna

AU - Bergmann, Annekatrin

AU - Haerting, Johannes

AU - Bolt, Hermann Maximilian

AU - Straif, Kurt

AU - Harth, Volker

PY - 2014/2/1

Y1 - 2014/2/1

N2 - PURPOSE: Epidemiological and toxicological studies point to a potential carcinogenic effect of dinitrotoluene (DNT), particularly with respect to renal and urothelial cancer.METHODS: The cohort comprised all men born between 1920 and 1974 (n = 16,441) who were gainfully employed between 1953 and 1990 in one of two underground copper mines in Mansfeld, Saxony-Anhalt, former German Democratic Republic, and who were followed up for cancer incidence, 1961-2005. Incident cancer cases were identified by record linkage with the Common Cancer Registry of the New Laender. Standardized incidence ratios (SIR) were calculated with the general population of Saxony-Anhalt as the reference.RESULTS: Standardized incidence ratios for all cancers were not significantly elevated in the cohort (SIR = 1.04; 95 % confidence intervals (CI) 0.96-1.14). We found an increase in lung cancer (SIR = 1.29; 1.13-1.46), but not in kidney cancer (SIR = 1.01; 95 % CI 0.79-1.27) or bladder cancer (SIR = 1.04; 95 % CI 0.82-1.30). Standardized incidence ratios stratified by duration of employment with DNT exposure indicated moderately increased risks for kidney and bladder cancer in cohort members with longer exposure.CONCLUSIONS: The SIR analysis of workers in the copper mining industry in comparison with the general population of Saxony-Anhalt overall did not indicate increased risks for renal or bladder cancer. However, results by years of exposure to DNT suggested weakly increased risks for outcomes of a priori interest, bladder and kidney cancer. A subsequent case-cohort analysis including expert assessment of DNT exposure and identification of additional cancer cases from a network of pathology institutes will provide further insight into a potential etiologic role of DNT in renal and urothelial cancer.

AB - PURPOSE: Epidemiological and toxicological studies point to a potential carcinogenic effect of dinitrotoluene (DNT), particularly with respect to renal and urothelial cancer.METHODS: The cohort comprised all men born between 1920 and 1974 (n = 16,441) who were gainfully employed between 1953 and 1990 in one of two underground copper mines in Mansfeld, Saxony-Anhalt, former German Democratic Republic, and who were followed up for cancer incidence, 1961-2005. Incident cancer cases were identified by record linkage with the Common Cancer Registry of the New Laender. Standardized incidence ratios (SIR) were calculated with the general population of Saxony-Anhalt as the reference.RESULTS: Standardized incidence ratios for all cancers were not significantly elevated in the cohort (SIR = 1.04; 95 % confidence intervals (CI) 0.96-1.14). We found an increase in lung cancer (SIR = 1.29; 1.13-1.46), but not in kidney cancer (SIR = 1.01; 95 % CI 0.79-1.27) or bladder cancer (SIR = 1.04; 95 % CI 0.82-1.30). Standardized incidence ratios stratified by duration of employment with DNT exposure indicated moderately increased risks for kidney and bladder cancer in cohort members with longer exposure.CONCLUSIONS: The SIR analysis of workers in the copper mining industry in comparison with the general population of Saxony-Anhalt overall did not indicate increased risks for renal or bladder cancer. However, results by years of exposure to DNT suggested weakly increased risks for outcomes of a priori interest, bladder and kidney cancer. A subsequent case-cohort analysis including expert assessment of DNT exposure and identification of additional cancer cases from a network of pathology institutes will provide further insight into a potential etiologic role of DNT in renal and urothelial cancer.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Air Pollutants, Occupational

KW - Carcinogens

KW - Cohort Studies

KW - Copper

KW - Dinitrobenzenes

KW - Germany

KW - Humans

KW - Incidence

KW - Kidney Neoplasms

KW - Male

KW - Middle Aged

KW - Mining

KW - Neoplasms

KW - Occupational Diseases

KW - Occupational Exposure

KW - Urinary Bladder Neoplasms

U2 - 10.1007/s00420-012-0842-9

DO - 10.1007/s00420-012-0842-9

M3 - SCORING: Journal article

C2 - 23274286

VL - 87

SP - 117

EP - 124

JO - INT ARCH OCC ENV HEA

JF - INT ARCH OCC ENV HEA

SN - 0340-0131

IS - 2

ER -