Can Understanding the Pathogenesis of Autoimmune Hepatitis Lead to Rational Therapy?
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Can Understanding the Pathogenesis of Autoimmune Hepatitis Lead to Rational Therapy? / Lohse, Ansgar W; Herkel, Johannes; Weiler-Normann, Christina.
In: DIGEST DIS, Vol. 35, No. 4, 2017, p. 367-370.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Can Understanding the Pathogenesis of Autoimmune Hepatitis Lead to Rational Therapy?
AU - Lohse, Ansgar W
AU - Herkel, Johannes
AU - Weiler-Normann, Christina
N1 - © 2017 S. Karger AG, Basel.
PY - 2017
Y1 - 2017
N2 - The pathogenesis of autoimmune hepatitis is still poorly understood and therefore, the therapy administered to treat this condition is broadly targeted immunosuppression. However, the aim of therapy in the future should be more specific; it should be a therapy that interrupts the pathogenetic cascade at defined checkpoints. Even though these checkpoints are not yet defined, possible targets of immunotherapy are emerging. These are specifically enhancing the regulatory T-cell activity, anti-cytokine interventions, in particular targeting the tumor necrosis factor, and hopefully in the foreseeable future, defining the key T-cell receptors used and developing new therapies directed against these.
AB - The pathogenesis of autoimmune hepatitis is still poorly understood and therefore, the therapy administered to treat this condition is broadly targeted immunosuppression. However, the aim of therapy in the future should be more specific; it should be a therapy that interrupts the pathogenetic cascade at defined checkpoints. Even though these checkpoints are not yet defined, possible targets of immunotherapy are emerging. These are specifically enhancing the regulatory T-cell activity, anti-cytokine interventions, in particular targeting the tumor necrosis factor, and hopefully in the foreseeable future, defining the key T-cell receptors used and developing new therapies directed against these.
KW - Animals
KW - Antigens
KW - Cytokines
KW - Genetic Predisposition to Disease
KW - Hepatitis, Autoimmune
KW - Humans
KW - Immunosuppression
KW - Immunotherapy
KW - Journal Article
KW - Review
U2 - 10.1159/000456588
DO - 10.1159/000456588
M3 - SCORING: Review article
C2 - 28468007
VL - 35
SP - 367
EP - 370
JO - DIGEST DIS
JF - DIGEST DIS
SN - 0257-2753
IS - 4
ER -