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Can Understanding the Pathogenesis of Autoimmune Hepatitis Lead to Rational Therapy?

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Can Understanding the Pathogenesis of Autoimmune Hepatitis Lead to Rational Therapy? / Lohse, Ansgar W; Herkel, Johannes; Weiler-Normann, Christina.

in: DIGEST DIS, Jahrgang 35, Nr. 4, 2017, S. 367-370.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Lohse, AW, Herkel, J & Weiler-Normann, C 2017, 'Can Understanding the Pathogenesis of Autoimmune Hepatitis Lead to Rational Therapy?', DIGEST DIS, Jg. 35, Nr. 4, S. 367-370. https://doi.org/10.1159/000456588

APA

Lohse, A. W., Herkel, J., & Weiler-Normann, C. (2017). Can Understanding the Pathogenesis of Autoimmune Hepatitis Lead to Rational Therapy? DIGEST DIS, 35(4), 367-370. https://doi.org/10.1159/000456588

Vancouver

Lohse AW, Herkel J, Weiler-Normann C. Can Understanding the Pathogenesis of Autoimmune Hepatitis Lead to Rational Therapy? DIGEST DIS. 2017;35(4):367-370. https://doi.org/10.1159/000456588

Bibtex

@article{2f8c44e39f5442008ddc4a26a9bd5795,
title = "Can Understanding the Pathogenesis of Autoimmune Hepatitis Lead to Rational Therapy?",
abstract = "The pathogenesis of autoimmune hepatitis is still poorly understood and therefore, the therapy administered to treat this condition is broadly targeted immunosuppression. However, the aim of therapy in the future should be more specific; it should be a therapy that interrupts the pathogenetic cascade at defined checkpoints. Even though these checkpoints are not yet defined, possible targets of immunotherapy are emerging. These are specifically enhancing the regulatory T-cell activity, anti-cytokine interventions, in particular targeting the tumor necrosis factor, and hopefully in the foreseeable future, defining the key T-cell receptors used and developing new therapies directed against these.",
keywords = "Animals, Antigens, Cytokines, Genetic Predisposition to Disease, Hepatitis, Autoimmune, Humans, Immunosuppression, Immunotherapy, Journal Article, Review",
author = "Lohse, {Ansgar W} and Johannes Herkel and Christina Weiler-Normann",
note = "{\textcopyright} 2017 S. Karger AG, Basel.",
year = "2017",
doi = "10.1159/000456588",
language = "English",
volume = "35",
pages = "367--370",
journal = "DIGEST DIS",
issn = "0257-2753",
publisher = "S. Karger AG",
number = "4",

}

RIS

TY - JOUR

T1 - Can Understanding the Pathogenesis of Autoimmune Hepatitis Lead to Rational Therapy?

AU - Lohse, Ansgar W

AU - Herkel, Johannes

AU - Weiler-Normann, Christina

N1 - © 2017 S. Karger AG, Basel.

PY - 2017

Y1 - 2017

N2 - The pathogenesis of autoimmune hepatitis is still poorly understood and therefore, the therapy administered to treat this condition is broadly targeted immunosuppression. However, the aim of therapy in the future should be more specific; it should be a therapy that interrupts the pathogenetic cascade at defined checkpoints. Even though these checkpoints are not yet defined, possible targets of immunotherapy are emerging. These are specifically enhancing the regulatory T-cell activity, anti-cytokine interventions, in particular targeting the tumor necrosis factor, and hopefully in the foreseeable future, defining the key T-cell receptors used and developing new therapies directed against these.

AB - The pathogenesis of autoimmune hepatitis is still poorly understood and therefore, the therapy administered to treat this condition is broadly targeted immunosuppression. However, the aim of therapy in the future should be more specific; it should be a therapy that interrupts the pathogenetic cascade at defined checkpoints. Even though these checkpoints are not yet defined, possible targets of immunotherapy are emerging. These are specifically enhancing the regulatory T-cell activity, anti-cytokine interventions, in particular targeting the tumor necrosis factor, and hopefully in the foreseeable future, defining the key T-cell receptors used and developing new therapies directed against these.

KW - Animals

KW - Antigens

KW - Cytokines

KW - Genetic Predisposition to Disease

KW - Hepatitis, Autoimmune

KW - Humans

KW - Immunosuppression

KW - Immunotherapy

KW - Journal Article

KW - Review

U2 - 10.1159/000456588

DO - 10.1159/000456588

M3 - SCORING: Review article

C2 - 28468007

VL - 35

SP - 367

EP - 370

JO - DIGEST DIS

JF - DIGEST DIS

SN - 0257-2753

IS - 4

ER -