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B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice

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B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice. / Gleiss, Jacob; Demestre, Maria; Spyra, Melanie; Eschenhagen, Thomas; Hagel, Christian; Mautner, Victor-Felix; Kluwe, Lan; Friedrich, Reinhard E.

In: IN VIVO, Vol. 27, No. 6, 2013, p. 723-7.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gleiss, J, Demestre, M, Spyra, M, Eschenhagen, T, Hagel, C, Mautner, V-F, Kluwe, L & Friedrich, RE 2013, 'B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice', IN VIVO, vol. 27, no. 6, pp. 723-7.

APA

Gleiss, J., Demestre, M., Spyra, M., Eschenhagen, T., Hagel, C., Mautner, V-F., Kluwe, L., & Friedrich, R. E. (2013). B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice. IN VIVO, 27(6), 723-7.

Vancouver

Gleiss J, Demestre M, Spyra M, Eschenhagen T, Hagel C, Mautner V-F et al. B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice. IN VIVO. 2013;27(6):723-7.

Bibtex

@article{5051cc2126fa4cbdb2ab50710c031734,
title = "B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice",
abstract = "BACKGROUND/AIM: Xenografted benign tumours in immunodeficient mice provide an in vivo model to study tumour biology and the effect of agents on tumour growth. Conventionally, these small grafts can only be monitored upon sacrificing the animals. We evaluated ultrasound biomicroscopy for monitoring such grafts in vivo.MATERIALS AND METHODS: Small fragments (<10 mm(3)) of a plexiform neurofibroma obtained from patients with established diagnosis of neurofibromatosis type-1 (NF1) were orthotopically-xenografted onto the sciatic nerve of immunodeficient mice and monitored using a high-resolution in vivo micro-imaging system.RESULTS: Grafts were identified in most cases and were distinguished from the surrounding inflammatory host tissues by detailed ultrasonographic signals. Graft sizes could be calculated precisely from serial scan sections and monitored during the whole course of drug treatment.CONCLUSION: High frequency sonographic measurement is a superior non-invasive method for monitoring small grafts of slowly growing benign tumours in mice in vivo, e.g. plexiform neurofibroma, and is especially suitable for tracing the effects of drugs at multiple time-points, thus allowing a very cost-effective follow-up.",
author = "Jacob Gleiss and Maria Demestre and Melanie Spyra and Thomas Eschenhagen and Christian Hagel and Victor-Felix Mautner and Lan Kluwe and Friedrich, {Reinhard E}",
year = "2013",
language = "English",
volume = "27",
pages = "723--7",
journal = "IN VIVO",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",
number = "6",

}

RIS

TY - JOUR

T1 - B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice

AU - Gleiss, Jacob

AU - Demestre, Maria

AU - Spyra, Melanie

AU - Eschenhagen, Thomas

AU - Hagel, Christian

AU - Mautner, Victor-Felix

AU - Kluwe, Lan

AU - Friedrich, Reinhard E

PY - 2013

Y1 - 2013

N2 - BACKGROUND/AIM: Xenografted benign tumours in immunodeficient mice provide an in vivo model to study tumour biology and the effect of agents on tumour growth. Conventionally, these small grafts can only be monitored upon sacrificing the animals. We evaluated ultrasound biomicroscopy for monitoring such grafts in vivo.MATERIALS AND METHODS: Small fragments (<10 mm(3)) of a plexiform neurofibroma obtained from patients with established diagnosis of neurofibromatosis type-1 (NF1) were orthotopically-xenografted onto the sciatic nerve of immunodeficient mice and monitored using a high-resolution in vivo micro-imaging system.RESULTS: Grafts were identified in most cases and were distinguished from the surrounding inflammatory host tissues by detailed ultrasonographic signals. Graft sizes could be calculated precisely from serial scan sections and monitored during the whole course of drug treatment.CONCLUSION: High frequency sonographic measurement is a superior non-invasive method for monitoring small grafts of slowly growing benign tumours in mice in vivo, e.g. plexiform neurofibroma, and is especially suitable for tracing the effects of drugs at multiple time-points, thus allowing a very cost-effective follow-up.

AB - BACKGROUND/AIM: Xenografted benign tumours in immunodeficient mice provide an in vivo model to study tumour biology and the effect of agents on tumour growth. Conventionally, these small grafts can only be monitored upon sacrificing the animals. We evaluated ultrasound biomicroscopy for monitoring such grafts in vivo.MATERIALS AND METHODS: Small fragments (<10 mm(3)) of a plexiform neurofibroma obtained from patients with established diagnosis of neurofibromatosis type-1 (NF1) were orthotopically-xenografted onto the sciatic nerve of immunodeficient mice and monitored using a high-resolution in vivo micro-imaging system.RESULTS: Grafts were identified in most cases and were distinguished from the surrounding inflammatory host tissues by detailed ultrasonographic signals. Graft sizes could be calculated precisely from serial scan sections and monitored during the whole course of drug treatment.CONCLUSION: High frequency sonographic measurement is a superior non-invasive method for monitoring small grafts of slowly growing benign tumours in mice in vivo, e.g. plexiform neurofibroma, and is especially suitable for tracing the effects of drugs at multiple time-points, thus allowing a very cost-effective follow-up.

M3 - SCORING: Journal article

C2 - 24292574

VL - 27

SP - 723

EP - 727

JO - IN VIVO

JF - IN VIVO

SN - 0258-851X

IS - 6

ER -