Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3'-diindolylmethane and chemotherapy drugs

Sergey V Nikulin; Boris Ya Alekseev; Nataliya S Sergeeva; Pavel A Karalkin; Elizaveta K Nezhurina; Valentina A Kirsanova; Irina K Sviridova; Suraja A Akhmedova; Nadezhda N Volchenko; Larisa V Bolotina; Andrey I Osipyants; Dmitry M Hushpulian; Maxim A Topchiy; Andrey F Asachenko; Anastasia P Koval; Dmitry S Shcherbo; Vsevolod I Kiselev; Dmitry S Mikhaylenko; Udo Schumacher; Andrey A Poloznikov

doi:10.1016/j.biochi.2020.10.007

Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3'-diindolylmethane and chemotherapy drugs

Standard

Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3'-diindolylmethane and chemotherapy drugs. / Nikulin, Sergey V; Alekseev, Boris Ya; Sergeeva, Nataliya S; Karalkin, Pavel A; Nezhurina, Elizaveta K; Kirsanova, Valentina A; Sviridova, Irina K; Akhmedova, Suraja A; Volchenko, Nadezhda N; Bolotina, Larisa V; Osipyants, Andrey I; Hushpulian, Dmitry M; Topchiy, Maxim A; Asachenko, Andrey F; Koval, Anastasia P; Shcherbo, Dmitry S; Kiselev, Vsevolod I; Mikhaylenko, Dmitry S; Schumacher, Udo; Poloznikov, Andrey A.

In: BIOCHIMIE, Vol. 179, 12.2020, p. 217 - 227.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Nikulin, SV, Alekseev, BY, Sergeeva, NS, Karalkin, PA, Nezhurina, EK, Kirsanova, VA, Sviridova, IK, Akhmedova, SA, Volchenko, NN, Bolotina, LV, Osipyants, AI, Hushpulian, DM, Topchiy, MA, Asachenko, AF, Koval, AP, Shcherbo, DS, Kiselev, VI, Mikhaylenko, DS, Schumacher, U & Poloznikov, AA 2020, 'Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3'-diindolylmethane and chemotherapy drugs', BIOCHIMIE, vol. 179, pp. 217 - 227. https://doi.org/10.1016/j.biochi.2020.10.007

APA

Nikulin, S. V., Alekseev, B. Y., Sergeeva, N. S., Karalkin, P. A., Nezhurina, E. K., Kirsanova, V. A., Sviridova, I. K., Akhmedova, S. A., Volchenko, N. N., Bolotina, L. V., Osipyants, A. I., Hushpulian, D. M., Topchiy, M. A., Asachenko, A. F., Koval, A. P., Shcherbo, D. S., Kiselev, V. I., Mikhaylenko, D. S., Schumacher, U., & Poloznikov, A. A. (2020). Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3'-diindolylmethane and chemotherapy drugs. BIOCHIMIE, 179, 217 - 227. https://doi.org/10.1016/j.biochi.2020.10.007

Vancouver

Nikulin SV, Alekseev BY, Sergeeva NS, Karalkin PA, Nezhurina EK, Kirsanova VA et al. Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3'-diindolylmethane and chemotherapy drugs. BIOCHIMIE. 2020 Dec;179:217 - 227. https://doi.org/10.1016/j.biochi.2020.10.007

Bibtex

@article{2cad1ae66d11488db4013d1d470de888,

title = "Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3'-diindolylmethane and chemotherapy drugs",

abstract = "Epigenetic alterations represent promising therapeutic targets in cancer treatment. Recently it was revealed that small molecules have the potential to act as microRNA silencers. Capacity to bind the discrete stem-looped structure of pre-miR-21 and prevent its maturation opens opportunities to utilize such compounds for the prevention of initiation, progression, and chemoresistance of cancer. Molecular simulations performed earlier identified 3,3'-diindolylmethane (DIM) as a potent microRNA-21 antagonist. However, data on DIM and microRNA-21 interplay is controversial, which may be caused by the limitations of the cell lines.",

author = "Nikulin, {Sergey V} and Alekseev, {Boris Ya} and Sergeeva, {Nataliya S} and Karalkin, {Pavel A} and Nezhurina, {Elizaveta K} and Kirsanova, {Valentina A} and Sviridova, {Irina K} and Akhmedova, {Suraja A} and Volchenko, {Nadezhda N} and Bolotina, {Larisa V} and Osipyants, {Andrey I} and Hushpulian, {Dmitry M} and Topchiy, {Maxim A} and Asachenko, {Andrey F} and Koval, {Anastasia P} and Shcherbo, {Dmitry S} and Kiselev, {Vsevolod I} and Mikhaylenko, {Dmitry S} and Udo Schumacher and Poloznikov, {Andrey A}",

year = "2020",

month = dec,

doi = "10.1016/j.biochi.2020.10.007",

language = "English",

volume = "179",

pages = "217 -- 227",

journal = "BIOCHIMIE",

issn = "0300-9084",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3'-diindolylmethane and chemotherapy drugs

AU - Nikulin, Sergey V

AU - Alekseev, Boris Ya

AU - Sergeeva, Nataliya S

AU - Karalkin, Pavel A

AU - Nezhurina, Elizaveta K

AU - Kirsanova, Valentina A

AU - Sviridova, Irina K

AU - Akhmedova, Suraja A

AU - Volchenko, Nadezhda N

AU - Bolotina, Larisa V

AU - Osipyants, Andrey I

AU - Hushpulian, Dmitry M

AU - Topchiy, Maxim A

AU - Asachenko, Andrey F

AU - Koval, Anastasia P

AU - Shcherbo, Dmitry S

AU - Kiselev, Vsevolod I

AU - Mikhaylenko, Dmitry S

AU - Schumacher, Udo

AU - Poloznikov, Andrey A

PY - 2020/12

Y1 - 2020/12

N2 - Epigenetic alterations represent promising therapeutic targets in cancer treatment. Recently it was revealed that small molecules have the potential to act as microRNA silencers. Capacity to bind the discrete stem-looped structure of pre-miR-21 and prevent its maturation opens opportunities to utilize such compounds for the prevention of initiation, progression, and chemoresistance of cancer. Molecular simulations performed earlier identified 3,3'-diindolylmethane (DIM) as a potent microRNA-21 antagonist. However, data on DIM and microRNA-21 interplay is controversial, which may be caused by the limitations of the cell lines.

AB - Epigenetic alterations represent promising therapeutic targets in cancer treatment. Recently it was revealed that small molecules have the potential to act as microRNA silencers. Capacity to bind the discrete stem-looped structure of pre-miR-21 and prevent its maturation opens opportunities to utilize such compounds for the prevention of initiation, progression, and chemoresistance of cancer. Molecular simulations performed earlier identified 3,3'-diindolylmethane (DIM) as a potent microRNA-21 antagonist. However, data on DIM and microRNA-21 interplay is controversial, which may be caused by the limitations of the cell lines.

U2 - 10.1016/j.biochi.2020.10.007

DO - 10.1016/j.biochi.2020.10.007

M3 - SCORING: Journal article

C2 - 33098909

VL - 179

SP - 217

EP - 227

JO - BIOCHIMIE

JF - BIOCHIMIE

SN - 0300-9084

ER -