Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3'-diindolylmethane and chemotherapy drugs
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Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3'-diindolylmethane and chemotherapy drugs. / Nikulin, Sergey V; Alekseev, Boris Ya; Sergeeva, Nataliya S; Karalkin, Pavel A; Nezhurina, Elizaveta K; Kirsanova, Valentina A; Sviridova, Irina K; Akhmedova, Suraja A; Volchenko, Nadezhda N; Bolotina, Larisa V; Osipyants, Andrey I; Hushpulian, Dmitry M; Topchiy, Maxim A; Asachenko, Andrey F; Koval, Anastasia P; Shcherbo, Dmitry S; Kiselev, Vsevolod I; Mikhaylenko, Dmitry S; Schumacher, Udo; Poloznikov, Andrey A.
in: BIOCHIMIE, Jahrgang 179, 12.2020, S. 217 - 227.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3'-diindolylmethane and chemotherapy drugs
AU - Nikulin, Sergey V
AU - Alekseev, Boris Ya
AU - Sergeeva, Nataliya S
AU - Karalkin, Pavel A
AU - Nezhurina, Elizaveta K
AU - Kirsanova, Valentina A
AU - Sviridova, Irina K
AU - Akhmedova, Suraja A
AU - Volchenko, Nadezhda N
AU - Bolotina, Larisa V
AU - Osipyants, Andrey I
AU - Hushpulian, Dmitry M
AU - Topchiy, Maxim A
AU - Asachenko, Andrey F
AU - Koval, Anastasia P
AU - Shcherbo, Dmitry S
AU - Kiselev, Vsevolod I
AU - Mikhaylenko, Dmitry S
AU - Schumacher, Udo
AU - Poloznikov, Andrey A
N1 - Copyright © 2020 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Epigenetic alterations represent promising therapeutic targets in cancer treatment. Recently it was revealed that small molecules have the potential to act as microRNA silencers. Capacity to bind the discrete stem-looped structure of pre-miR-21 and prevent its maturation opens opportunities to utilize such compounds for the prevention of initiation, progression, and chemoresistance of cancer. Molecular simulations performed earlier identified 3,3'-diindolylmethane (DIM) as a potent microRNA-21 antagonist. However, data on DIM and microRNA-21 interplay is controversial, which may be caused by the limitations of the cell lines.
AB - Epigenetic alterations represent promising therapeutic targets in cancer treatment. Recently it was revealed that small molecules have the potential to act as microRNA silencers. Capacity to bind the discrete stem-looped structure of pre-miR-21 and prevent its maturation opens opportunities to utilize such compounds for the prevention of initiation, progression, and chemoresistance of cancer. Molecular simulations performed earlier identified 3,3'-diindolylmethane (DIM) as a potent microRNA-21 antagonist. However, data on DIM and microRNA-21 interplay is controversial, which may be caused by the limitations of the cell lines.
U2 - 10.1016/j.biochi.2020.10.007
DO - 10.1016/j.biochi.2020.10.007
M3 - SCORING: Journal article
C2 - 33098909
VL - 179
SP - 217
EP - 227
JO - BIOCHIMIE
JF - BIOCHIMIE
SN - 0300-9084
ER -