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BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks

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BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks. / Richiardi, Jonas; Altmann, Andre; Milazzo, Anna-Clare; Chang, Catie; Chakravarty, M Mallar; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Conrod, Patricia; Fauth-Bühler, Mira; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Lemaître, Hervé; Mann, Karl F; Martinot, Jean-Luc; Nees, Frauke; Paus, Tomáš; Pausova, Zdenka; Rietschel, Marcella; Robbins, Trevor W; Smolka, Michael N; Spanagel, Rainer; Ströhle, Andreas; Schumann, Gunter; Hawrylycz, Mike; Poline, Jean-Baptiste; Greicius, Michael D; IMAGEN Consortium.

In: SCIENCE, Vol. 348, No. 6240, 12.06.2015, p. 1241-4.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Richiardi, J, Altmann, A, Milazzo, A-C, Chang, C, Chakravarty, MM, Banaschewski, T, Barker, GJ, Bokde, ALW, Bromberg, U, Büchel, C, Conrod, P, Fauth-Bühler, M, Flor, H, Frouin, V, Gallinat, J, Garavan, H, Gowland, P, Heinz, A, Lemaître, H, Mann, KF, Martinot, J-L, Nees, F, Paus, T, Pausova, Z, Rietschel, M, Robbins, TW, Smolka, MN, Spanagel, R, Ströhle, A, Schumann, G, Hawrylycz, M, Poline, J-B, Greicius, MD & IMAGEN Consortium 2015, 'BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks', SCIENCE, vol. 348, no. 6240, pp. 1241-4. https://doi.org/10.1126/science.1255905

APA

Richiardi, J., Altmann, A., Milazzo, A-C., Chang, C., Chakravarty, M. M., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Bromberg, U., Büchel, C., Conrod, P., Fauth-Bühler, M., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Lemaître, H., ... IMAGEN Consortium (2015). BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks. SCIENCE, 348(6240), 1241-4. https://doi.org/10.1126/science.1255905

Vancouver

Richiardi J, Altmann A, Milazzo A-C, Chang C, Chakravarty MM, Banaschewski T et al. BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks. SCIENCE. 2015 Jun 12;348(6240):1241-4. https://doi.org/10.1126/science.1255905

Bibtex

@article{1e20ddefb7ec428e85f878152765b2f2,
title = "BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks",
abstract = "During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional brain networks defined with resting-state functional magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem brain tissue data set. The set of 136 genes we identify is significantly enriched for ion channels. Polymorphisms in this set of genes significantly affect resting-state functional connectivity in a large sample of healthy adolescents. Expression levels of these genes are also significantly associated with axonal connectivity in the mouse. The results provide convergent, multimodal evidence that resting-state functional networks correlate with the orchestrated activity of dozens of genes linked to ion channel activity and synaptic function.",
keywords = "Adolescent, Adult, Animals, Brain, Female, Gene Expression, Humans, Ion Channels, Magnetic Resonance Imaging, Male, Mice, Nerve Net, Neural Pathways, Polymorphism, Genetic, Rest, Synapses, Transcriptome, Young Adult",
author = "Jonas Richiardi and Andre Altmann and Anna-Clare Milazzo and Catie Chang and Chakravarty, {M Mallar} and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Patricia Conrod and Mira Fauth-B{\"u}hler and Herta Flor and Vincent Frouin and J{\"u}rgen Gallinat and Hugh Garavan and Penny Gowland and Andreas Heinz and Herv{\'e} Lema{\^i}tre and Mann, {Karl F} and Jean-Luc Martinot and Frauke Nees and Tom{\'a}{\v s} Paus and Zdenka Pausova and Marcella Rietschel and Robbins, {Trevor W} and Smolka, {Michael N} and Rainer Spanagel and Andreas Str{\"o}hle and Gunter Schumann and Mike Hawrylycz and Jean-Baptiste Poline and Greicius, {Michael D} and {IMAGEN Consortium}",
note = "Copyright {\textcopyright} 2015, American Association for the Advancement of Science.",
year = "2015",
month = jun,
day = "12",
doi = "10.1126/science.1255905",
language = "English",
volume = "348",
pages = "1241--4",
journal = "SCIENCE",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6240",

}

RIS

TY - JOUR

T1 - BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks

AU - Richiardi, Jonas

AU - Altmann, Andre

AU - Milazzo, Anna-Clare

AU - Chang, Catie

AU - Chakravarty, M Mallar

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Conrod, Patricia

AU - Fauth-Bühler, Mira

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gallinat, Jürgen

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Lemaître, Hervé

AU - Mann, Karl F

AU - Martinot, Jean-Luc

AU - Nees, Frauke

AU - Paus, Tomáš

AU - Pausova, Zdenka

AU - Rietschel, Marcella

AU - Robbins, Trevor W

AU - Smolka, Michael N

AU - Spanagel, Rainer

AU - Ströhle, Andreas

AU - Schumann, Gunter

AU - Hawrylycz, Mike

AU - Poline, Jean-Baptiste

AU - Greicius, Michael D

AU - IMAGEN Consortium

N1 - Copyright © 2015, American Association for the Advancement of Science.

PY - 2015/6/12

Y1 - 2015/6/12

N2 - During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional brain networks defined with resting-state functional magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem brain tissue data set. The set of 136 genes we identify is significantly enriched for ion channels. Polymorphisms in this set of genes significantly affect resting-state functional connectivity in a large sample of healthy adolescents. Expression levels of these genes are also significantly associated with axonal connectivity in the mouse. The results provide convergent, multimodal evidence that resting-state functional networks correlate with the orchestrated activity of dozens of genes linked to ion channel activity and synaptic function.

AB - During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional brain networks defined with resting-state functional magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem brain tissue data set. The set of 136 genes we identify is significantly enriched for ion channels. Polymorphisms in this set of genes significantly affect resting-state functional connectivity in a large sample of healthy adolescents. Expression levels of these genes are also significantly associated with axonal connectivity in the mouse. The results provide convergent, multimodal evidence that resting-state functional networks correlate with the orchestrated activity of dozens of genes linked to ion channel activity and synaptic function.

KW - Adolescent

KW - Adult

KW - Animals

KW - Brain

KW - Female

KW - Gene Expression

KW - Humans

KW - Ion Channels

KW - Magnetic Resonance Imaging

KW - Male

KW - Mice

KW - Nerve Net

KW - Neural Pathways

KW - Polymorphism, Genetic

KW - Rest

KW - Synapses

KW - Transcriptome

KW - Young Adult

U2 - 10.1126/science.1255905

DO - 10.1126/science.1255905

M3 - SCORING: Journal article

C2 - 26068849

VL - 348

SP - 1241

EP - 1244

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 6240

ER -