BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks
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BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks. / Richiardi, Jonas; Altmann, Andre; Milazzo, Anna-Clare; Chang, Catie; Chakravarty, M Mallar; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Conrod, Patricia; Fauth-Bühler, Mira; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Lemaître, Hervé; Mann, Karl F; Martinot, Jean-Luc; Nees, Frauke; Paus, Tomáš; Pausova, Zdenka; Rietschel, Marcella; Robbins, Trevor W; Smolka, Michael N; Spanagel, Rainer; Ströhle, Andreas; Schumann, Gunter; Hawrylycz, Mike; Poline, Jean-Baptiste; Greicius, Michael D; IMAGEN Consortium.
in: SCIENCE, Jahrgang 348, Nr. 6240, 12.06.2015, S. 1241-4.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks
AU - Richiardi, Jonas
AU - Altmann, Andre
AU - Milazzo, Anna-Clare
AU - Chang, Catie
AU - Chakravarty, M Mallar
AU - Banaschewski, Tobias
AU - Barker, Gareth J
AU - Bokde, Arun L W
AU - Bromberg, Uli
AU - Büchel, Christian
AU - Conrod, Patricia
AU - Fauth-Bühler, Mira
AU - Flor, Herta
AU - Frouin, Vincent
AU - Gallinat, Jürgen
AU - Garavan, Hugh
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Lemaître, Hervé
AU - Mann, Karl F
AU - Martinot, Jean-Luc
AU - Nees, Frauke
AU - Paus, Tomáš
AU - Pausova, Zdenka
AU - Rietschel, Marcella
AU - Robbins, Trevor W
AU - Smolka, Michael N
AU - Spanagel, Rainer
AU - Ströhle, Andreas
AU - Schumann, Gunter
AU - Hawrylycz, Mike
AU - Poline, Jean-Baptiste
AU - Greicius, Michael D
AU - IMAGEN Consortium
N1 - Copyright © 2015, American Association for the Advancement of Science.
PY - 2015/6/12
Y1 - 2015/6/12
N2 - During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional brain networks defined with resting-state functional magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem brain tissue data set. The set of 136 genes we identify is significantly enriched for ion channels. Polymorphisms in this set of genes significantly affect resting-state functional connectivity in a large sample of healthy adolescents. Expression levels of these genes are also significantly associated with axonal connectivity in the mouse. The results provide convergent, multimodal evidence that resting-state functional networks correlate with the orchestrated activity of dozens of genes linked to ion channel activity and synaptic function.
AB - During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional brain networks defined with resting-state functional magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem brain tissue data set. The set of 136 genes we identify is significantly enriched for ion channels. Polymorphisms in this set of genes significantly affect resting-state functional connectivity in a large sample of healthy adolescents. Expression levels of these genes are also significantly associated with axonal connectivity in the mouse. The results provide convergent, multimodal evidence that resting-state functional networks correlate with the orchestrated activity of dozens of genes linked to ion channel activity and synaptic function.
KW - Adolescent
KW - Adult
KW - Animals
KW - Brain
KW - Female
KW - Gene Expression
KW - Humans
KW - Ion Channels
KW - Magnetic Resonance Imaging
KW - Male
KW - Mice
KW - Nerve Net
KW - Neural Pathways
KW - Polymorphism, Genetic
KW - Rest
KW - Synapses
KW - Transcriptome
KW - Young Adult
U2 - 10.1126/science.1255905
DO - 10.1126/science.1255905
M3 - SCORING: Journal article
C2 - 26068849
VL - 348
SP - 1241
EP - 1244
JO - SCIENCE
JF - SCIENCE
SN - 0036-8075
IS - 6240
ER -