Brain aging differs with cognitive ability regardless of education
Standard
Brain aging differs with cognitive ability regardless of education. / Walhovd, Kristine B; Nyberg, Lars; Lindenberger, Ulman; Amlien, Inge K; Sørensen, Øystein; Wang, Yunpeng; Mowinckel, Athanasia M; Kievit, Rogier A; Ebmeier, Klaus P; Bartrés-Faz, David; Kühn, Simone; Boraxbekk, Carl-Johan; Ghisletta, Paolo; Madsen, Kathrine Skak; Baaré, Willliam F C; Zsoldos, Enikő; Magnussen, Fredrik; Vidal-Piñeiro, Didac; Penninx, Brenda; Fjell, Anders M.
In: SCI REP-UK, Vol. 12, 13886, 16.08.2022.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Brain aging differs with cognitive ability regardless of education
AU - Walhovd, Kristine B
AU - Nyberg, Lars
AU - Lindenberger, Ulman
AU - Amlien, Inge K
AU - Sørensen, Øystein
AU - Wang, Yunpeng
AU - Mowinckel, Athanasia M
AU - Kievit, Rogier A
AU - Ebmeier, Klaus P
AU - Bartrés-Faz, David
AU - Kühn, Simone
AU - Boraxbekk, Carl-Johan
AU - Ghisletta, Paolo
AU - Madsen, Kathrine Skak
AU - Baaré, Willliam F C
AU - Zsoldos, Enikő
AU - Magnussen, Fredrik
AU - Vidal-Piñeiro, Didac
AU - Penninx, Brenda
AU - Fjell, Anders M
N1 - © 2022. The Author(s).
PY - 2022/8/16
Y1 - 2022/8/16
N2 - Higher general cognitive ability (GCA) is associated with lower risk of neurodegenerative disorders, but neural mechanisms are unknown. GCA could be associated with more cortical tissue, from young age, i.e. brain reserve, or less cortical atrophy in adulthood, i.e. brain maintenance. Controlling for education, we investigated the relative association of GCA with reserve and maintenance of cortical volume, -area and -thickness through the adult lifespan, using multiple longitudinal cognitively healthy brain imaging cohorts (n = 3327, 7002 MRI scans, baseline age 20-88 years, followed-up for up to 11 years). There were widespread positive relationships between GCA and cortical characteristics (level-level associations). In select regions, higher baseline GCA was associated with less atrophy over time (level-change associations). Relationships remained when controlling for polygenic scores for both GCA and education. Our findings suggest that higher GCA is associated with cortical volumes by both brain reserve and -maintenance mechanisms through the adult lifespan.
AB - Higher general cognitive ability (GCA) is associated with lower risk of neurodegenerative disorders, but neural mechanisms are unknown. GCA could be associated with more cortical tissue, from young age, i.e. brain reserve, or less cortical atrophy in adulthood, i.e. brain maintenance. Controlling for education, we investigated the relative association of GCA with reserve and maintenance of cortical volume, -area and -thickness through the adult lifespan, using multiple longitudinal cognitively healthy brain imaging cohorts (n = 3327, 7002 MRI scans, baseline age 20-88 years, followed-up for up to 11 years). There were widespread positive relationships between GCA and cortical characteristics (level-level associations). In select regions, higher baseline GCA was associated with less atrophy over time (level-change associations). Relationships remained when controlling for polygenic scores for both GCA and education. Our findings suggest that higher GCA is associated with cortical volumes by both brain reserve and -maintenance mechanisms through the adult lifespan.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Aging
KW - Atrophy
KW - Brain/diagnostic imaging
KW - Cognition
KW - Cognitive Reserve
KW - Humans
KW - Magnetic Resonance Imaging/methods
KW - Middle Aged
KW - Young Adult
U2 - 10.1038/s41598-022-17727-6
DO - 10.1038/s41598-022-17727-6
M3 - SCORING: Journal article
C2 - 35974034
VL - 12
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
M1 - 13886
ER -