Brain aging differs with cognitive ability regardless of education

Kristine B Walhovd; Lars Nyberg; Ulman Lindenberger; Inge K Amlien; Øystein Sørensen; Yunpeng Wang; Athanasia M Mowinckel; Rogier A Kievit; Klaus P Ebmeier; David Bartrés-Faz; Simone Kühn; Carl-Johan Boraxbekk; Paolo Ghisletta; Kathrine Skak Madsen; Willliam F C Baaré; Enikő Zsoldos; Fredrik Magnussen; Didac Vidal-Piñeiro; Brenda Penninx; Anders M Fjell

doi:10.1038/s41598-022-17727-6

Brain aging differs with cognitive ability regardless of education

Standard

Brain aging differs with cognitive ability regardless of education. / Walhovd, Kristine B; Nyberg, Lars; Lindenberger, Ulman; Amlien, Inge K; Sørensen, Øystein; Wang, Yunpeng; Mowinckel, Athanasia M; Kievit, Rogier A; Ebmeier, Klaus P; Bartrés-Faz, David; Kühn, Simone; Boraxbekk, Carl-Johan; Ghisletta, Paolo; Madsen, Kathrine Skak; Baaré, Willliam F C; Zsoldos, Enikő; Magnussen, Fredrik; Vidal-Piñeiro, Didac; Penninx, Brenda; Fjell, Anders M.

in: SCI REP-UK, Jahrgang 12, 13886, 16.08.2022.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Walhovd, KB, Nyberg, L, Lindenberger, U, Amlien, IK, Sørensen, Ø, Wang, Y, Mowinckel, AM, Kievit, RA, Ebmeier, KP, Bartrés-Faz, D, Kühn, S, Boraxbekk, C-J, Ghisletta, P, Madsen, KS, Baaré, WFC, Zsoldos, E, Magnussen, F, Vidal-Piñeiro, D, Penninx, B & Fjell, AM 2022, 'Brain aging differs with cognitive ability regardless of education', SCI REP-UK, Jg. 12, 13886. https://doi.org/10.1038/s41598-022-17727-6

APA

Walhovd, K. B., Nyberg, L., Lindenberger, U., Amlien, I. K., Sørensen, Ø., Wang, Y., Mowinckel, A. M., Kievit, R. A., Ebmeier, K. P., Bartrés-Faz, D., Kühn, S., Boraxbekk, C-J., Ghisletta, P., Madsen, K. S., Baaré, W. F. C., Zsoldos, E., Magnussen, F., Vidal-Piñeiro, D., Penninx, B., & Fjell, A. M. (2022). Brain aging differs with cognitive ability regardless of education. SCI REP-UK, 12, [13886]. https://doi.org/10.1038/s41598-022-17727-6

Vancouver

Walhovd KB, Nyberg L, Lindenberger U, Amlien IK, Sørensen Ø, Wang Y et al. Brain aging differs with cognitive ability regardless of education. SCI REP-UK. 2022 Aug 16;12. 13886. https://doi.org/10.1038/s41598-022-17727-6

Bibtex

@article{cfae181456d44a5793e540865d25fd8f,

title = "Brain aging differs with cognitive ability regardless of education",

abstract = "Higher general cognitive ability (GCA) is associated with lower risk of neurodegenerative disorders, but neural mechanisms are unknown. GCA could be associated with more cortical tissue, from young age, i.e. brain reserve, or less cortical atrophy in adulthood, i.e. brain maintenance. Controlling for education, we investigated the relative association of GCA with reserve and maintenance of cortical volume, -area and -thickness through the adult lifespan, using multiple longitudinal cognitively healthy brain imaging cohorts (n = 3327, 7002 MRI scans, baseline age 20-88 years, followed-up for up to 11 years). There were widespread positive relationships between GCA and cortical characteristics (level-level associations). In select regions, higher baseline GCA was associated with less atrophy over time (level-change associations). Relationships remained when controlling for polygenic scores for both GCA and education. Our findings suggest that higher GCA is associated with cortical volumes by both brain reserve and -maintenance mechanisms through the adult lifespan.",

keywords = "Adult, Aged, Aged, 80 and over, Aging, Atrophy, Brain/diagnostic imaging, Cognition, Cognitive Reserve, Humans, Magnetic Resonance Imaging/methods, Middle Aged, Young Adult",

author = "Walhovd, {Kristine B} and Lars Nyberg and Ulman Lindenberger and Amlien, {Inge K} and {\O}ystein S{\o}rensen and Yunpeng Wang and Mowinckel, {Athanasia M} and Kievit, {Rogier A} and Ebmeier, {Klaus P} and David Bartr{\'e}s-Faz and Simone K{\"u}hn and Carl-Johan Boraxbekk and Paolo Ghisletta and Madsen, {Kathrine Skak} and Baar{\'e}, {Willliam F C} and Enik{\H o} Zsoldos and Fredrik Magnussen and Didac Vidal-Pi{\~n}eiro and Brenda Penninx and Fjell, {Anders M}",

note = "{\textcopyright} 2022. The Author(s).",

year = "2022",

month = aug,

day = "16",

doi = "10.1038/s41598-022-17727-6",

language = "English",

volume = "12",

journal = "SCI REP-UK",

issn = "2045-2322",

publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Brain aging differs with cognitive ability regardless of education

AU - Walhovd, Kristine B

AU - Nyberg, Lars

AU - Lindenberger, Ulman

AU - Amlien, Inge K

AU - Sørensen, Øystein

AU - Wang, Yunpeng

AU - Mowinckel, Athanasia M

AU - Kievit, Rogier A

AU - Ebmeier, Klaus P

AU - Bartrés-Faz, David

AU - Kühn, Simone

AU - Boraxbekk, Carl-Johan

AU - Ghisletta, Paolo

AU - Madsen, Kathrine Skak

AU - Baaré, Willliam F C

AU - Zsoldos, Enikő

AU - Magnussen, Fredrik

AU - Vidal-Piñeiro, Didac

AU - Penninx, Brenda

AU - Fjell, Anders M

PY - 2022/8/16

Y1 - 2022/8/16

N2 - Higher general cognitive ability (GCA) is associated with lower risk of neurodegenerative disorders, but neural mechanisms are unknown. GCA could be associated with more cortical tissue, from young age, i.e. brain reserve, or less cortical atrophy in adulthood, i.e. brain maintenance. Controlling for education, we investigated the relative association of GCA with reserve and maintenance of cortical volume, -area and -thickness through the adult lifespan, using multiple longitudinal cognitively healthy brain imaging cohorts (n = 3327, 7002 MRI scans, baseline age 20-88 years, followed-up for up to 11 years). There were widespread positive relationships between GCA and cortical characteristics (level-level associations). In select regions, higher baseline GCA was associated with less atrophy over time (level-change associations). Relationships remained when controlling for polygenic scores for both GCA and education. Our findings suggest that higher GCA is associated with cortical volumes by both brain reserve and -maintenance mechanisms through the adult lifespan.

AB - Higher general cognitive ability (GCA) is associated with lower risk of neurodegenerative disorders, but neural mechanisms are unknown. GCA could be associated with more cortical tissue, from young age, i.e. brain reserve, or less cortical atrophy in adulthood, i.e. brain maintenance. Controlling for education, we investigated the relative association of GCA with reserve and maintenance of cortical volume, -area and -thickness through the adult lifespan, using multiple longitudinal cognitively healthy brain imaging cohorts (n = 3327, 7002 MRI scans, baseline age 20-88 years, followed-up for up to 11 years). There were widespread positive relationships between GCA and cortical characteristics (level-level associations). In select regions, higher baseline GCA was associated with less atrophy over time (level-change associations). Relationships remained when controlling for polygenic scores for both GCA and education. Our findings suggest that higher GCA is associated with cortical volumes by both brain reserve and -maintenance mechanisms through the adult lifespan.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aging

KW - Atrophy

KW - Brain/diagnostic imaging

KW - Cognition

KW - Cognitive Reserve

KW - Humans

KW - Magnetic Resonance Imaging/methods

KW - Middle Aged

KW - Young Adult

U2 - 10.1038/s41598-022-17727-6

DO - 10.1038/s41598-022-17727-6

M3 - SCORING: Journal article

C2 - 35974034

VL - 12

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

M1 - 13886

ER -