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Bone substitutes enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds

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Bone substitutes enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds. / Hanken, Henning; Alpers, Janna; Böbel, Melanie; Wöltje, Michael; Hartjen, Philip; Friedrich, Reinhard E; Jung, Ole; Rendenbach, Carsten; Gröbe, Alexander; Heiland, Max; Al-Dam, Ahmed; Eichhorn, Wolfgang; Smeets, Ralf.

In: IN VIVO, Vol. 28, No. 5, 06.09.2014, p. 733-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hanken, H, Alpers, J, Böbel, M, Wöltje, M, Hartjen, P, Friedrich, RE, Jung, O, Rendenbach, C, Gröbe, A, Heiland, M, Al-Dam, A, Eichhorn, W & Smeets, R 2014, 'Bone substitutes enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds', IN VIVO, vol. 28, no. 5, pp. 733-9.

APA

Hanken, H., Alpers, J., Böbel, M., Wöltje, M., Hartjen, P., Friedrich, R. E., Jung, O., Rendenbach, C., Gröbe, A., Heiland, M., Al-Dam, A., Eichhorn, W., & Smeets, R. (2014). Bone substitutes enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds. IN VIVO, 28(5), 733-9.

Vancouver

Hanken H, Alpers J, Böbel M, Wöltje M, Hartjen P, Friedrich RE et al. Bone substitutes enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds. IN VIVO. 2014 Sep 6;28(5):733-9.

Bibtex

@article{ff42b0a8ce0f49b3a0a03cc407eec2f8,
title = "Bone substitutes enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds",
abstract = "AIM: The present study aimed to find bone substitutes to enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds in the absence of dexamethasone.MATERIALS AND METHODS: Seven commercial bone substitutes were added to a three-dimensional fibrin-matrix containing rat mesenchymal stem cells in a biocompatible poly-L-lactic-acid mesh. Cell viability, cytotoxicity and alkaline phosphatase activity were followed for three weeks. Expression of bone markers was examined by qualitative evaluation of corresponding transcripts.RESULTS: Six out of the seven bone derivatives exhibited an osteogenic-enhancing effect.CONCLUSION: The osteogenic-enhancing effect of the evaluated bone substitutes suggests their potential clinical application for preparation of autologous bone replacement material in three-dimensional carriers.",
author = "Henning Hanken and Janna Alpers and Melanie B{\"o}bel and Michael W{\"o}ltje and Philip Hartjen and Friedrich, {Reinhard E} and Ole Jung and Carsten Rendenbach and Alexander Gr{\"o}be and Max Heiland and Ahmed Al-Dam and Wolfgang Eichhorn and Ralf Smeets",
note = "Jana Alpers + Ole Jung INTERN MKG",
year = "2014",
month = sep,
day = "6",
language = "English",
volume = "28",
pages = "733--9",
journal = "IN VIVO",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",
number = "5",

}

RIS

TY - JOUR

T1 - Bone substitutes enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds

AU - Hanken, Henning

AU - Alpers, Janna

AU - Böbel, Melanie

AU - Wöltje, Michael

AU - Hartjen, Philip

AU - Friedrich, Reinhard E

AU - Jung, Ole

AU - Rendenbach, Carsten

AU - Gröbe, Alexander

AU - Heiland, Max

AU - Al-Dam, Ahmed

AU - Eichhorn, Wolfgang

AU - Smeets, Ralf

N1 - Jana Alpers + Ole Jung INTERN MKG

PY - 2014/9/6

Y1 - 2014/9/6

N2 - AIM: The present study aimed to find bone substitutes to enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds in the absence of dexamethasone.MATERIALS AND METHODS: Seven commercial bone substitutes were added to a three-dimensional fibrin-matrix containing rat mesenchymal stem cells in a biocompatible poly-L-lactic-acid mesh. Cell viability, cytotoxicity and alkaline phosphatase activity were followed for three weeks. Expression of bone markers was examined by qualitative evaluation of corresponding transcripts.RESULTS: Six out of the seven bone derivatives exhibited an osteogenic-enhancing effect.CONCLUSION: The osteogenic-enhancing effect of the evaluated bone substitutes suggests their potential clinical application for preparation of autologous bone replacement material in three-dimensional carriers.

AB - AIM: The present study aimed to find bone substitutes to enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds in the absence of dexamethasone.MATERIALS AND METHODS: Seven commercial bone substitutes were added to a three-dimensional fibrin-matrix containing rat mesenchymal stem cells in a biocompatible poly-L-lactic-acid mesh. Cell viability, cytotoxicity and alkaline phosphatase activity were followed for three weeks. Expression of bone markers was examined by qualitative evaluation of corresponding transcripts.RESULTS: Six out of the seven bone derivatives exhibited an osteogenic-enhancing effect.CONCLUSION: The osteogenic-enhancing effect of the evaluated bone substitutes suggests their potential clinical application for preparation of autologous bone replacement material in three-dimensional carriers.

M3 - SCORING: Journal article

C2 - 25189884

VL - 28

SP - 733

EP - 739

JO - IN VIVO

JF - IN VIVO

SN - 0258-851X

IS - 5

ER -