Bone substitutes enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds
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Bone substitutes enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds. / Hanken, Henning; Alpers, Janna; Böbel, Melanie; Wöltje, Michael; Hartjen, Philip; Friedrich, Reinhard E; Jung, Ole; Rendenbach, Carsten; Gröbe, Alexander; Heiland, Max; Al-Dam, Ahmed; Eichhorn, Wolfgang; Smeets, Ralf.
in: IN VIVO, Jahrgang 28, Nr. 5, 06.09.2014, S. 733-9.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Bone substitutes enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds
AU - Hanken, Henning
AU - Alpers, Janna
AU - Böbel, Melanie
AU - Wöltje, Michael
AU - Hartjen, Philip
AU - Friedrich, Reinhard E
AU - Jung, Ole
AU - Rendenbach, Carsten
AU - Gröbe, Alexander
AU - Heiland, Max
AU - Al-Dam, Ahmed
AU - Eichhorn, Wolfgang
AU - Smeets, Ralf
N1 - Jana Alpers + Ole Jung INTERN MKG
PY - 2014/9/6
Y1 - 2014/9/6
N2 - AIM: The present study aimed to find bone substitutes to enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds in the absence of dexamethasone.MATERIALS AND METHODS: Seven commercial bone substitutes were added to a three-dimensional fibrin-matrix containing rat mesenchymal stem cells in a biocompatible poly-L-lactic-acid mesh. Cell viability, cytotoxicity and alkaline phosphatase activity were followed for three weeks. Expression of bone markers was examined by qualitative evaluation of corresponding transcripts.RESULTS: Six out of the seven bone derivatives exhibited an osteogenic-enhancing effect.CONCLUSION: The osteogenic-enhancing effect of the evaluated bone substitutes suggests their potential clinical application for preparation of autologous bone replacement material in three-dimensional carriers.
AB - AIM: The present study aimed to find bone substitutes to enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds in the absence of dexamethasone.MATERIALS AND METHODS: Seven commercial bone substitutes were added to a three-dimensional fibrin-matrix containing rat mesenchymal stem cells in a biocompatible poly-L-lactic-acid mesh. Cell viability, cytotoxicity and alkaline phosphatase activity were followed for three weeks. Expression of bone markers was examined by qualitative evaluation of corresponding transcripts.RESULTS: Six out of the seven bone derivatives exhibited an osteogenic-enhancing effect.CONCLUSION: The osteogenic-enhancing effect of the evaluated bone substitutes suggests their potential clinical application for preparation of autologous bone replacement material in three-dimensional carriers.
M3 - SCORING: Journal article
C2 - 25189884
VL - 28
SP - 733
EP - 739
JO - IN VIVO
JF - IN VIVO
SN - 0258-851X
IS - 5
ER -