Blood outgrowth endothelial cells from chronic myeloid leukaemia patients are BCR/ABL1 negative.
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Blood outgrowth endothelial cells from chronic myeloid leukaemia patients are BCR/ABL1 negative. / Wellbrock, Jasmin; Schultze, Alexander; Schafhausen, Philippe; Otterstetter, Svenja; Dierlamm, Judith; Bokemeyer, Carsten; Brümmendorf, Tim; Fiedler, Walter; Loges, Sonja.
In: BRIT J HAEMATOL, Vol. 142, No. 1, 1, 2008, p. 115-118.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Blood outgrowth endothelial cells from chronic myeloid leukaemia patients are BCR/ABL1 negative.
AU - Wellbrock, Jasmin
AU - Schultze, Alexander
AU - Schafhausen, Philippe
AU - Otterstetter, Svenja
AU - Dierlamm, Judith
AU - Bokemeyer, Carsten
AU - Brümmendorf, Tim
AU - Fiedler, Walter
AU - Loges, Sonja
PY - 2008
Y1 - 2008
N2 - The existence of adult haemangioblasts with dual haematopoietic and endothelial developmental potential was confirmed after detection of Ph(+) vascular endothelial cells in chronic myeloid leukaemia (CML) patients. Blood outgrowth endothelial cells (OECs) from CML patients were found not to harbour the Philadelphia translocation and were thus not clonally related to BRC/ABL1(+) hematopoietic progenitors, but comprised a distinct subfraction of endothelial cells. Remarkably, the frequency of CML-derived OECs was 9-fold higher as compared to healthy donors (n = 19 and n = 300, respectively; P <0.0001) and these cells showed increased proliferative potential, possibly reflecting the mobilisation of OEC progenitors by pro-angiogenic cytokines.
AB - The existence of adult haemangioblasts with dual haematopoietic and endothelial developmental potential was confirmed after detection of Ph(+) vascular endothelial cells in chronic myeloid leukaemia (CML) patients. Blood outgrowth endothelial cells (OECs) from CML patients were found not to harbour the Philadelphia translocation and were thus not clonally related to BRC/ABL1(+) hematopoietic progenitors, but comprised a distinct subfraction of endothelial cells. Remarkably, the frequency of CML-derived OECs was 9-fold higher as compared to healthy donors (n = 19 and n = 300, respectively; P <0.0001) and these cells showed increased proliferative potential, possibly reflecting the mobilisation of OEC progenitors by pro-angiogenic cytokines.
M3 - SCORING: Zeitschriftenaufsatz
VL - 142
SP - 115
EP - 118
JO - BRIT J HAEMATOL
JF - BRIT J HAEMATOL
SN - 0007-1048
IS - 1
M1 - 1
ER -