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Blood outgrowth endothelial cells from chronic myeloid leukaemia patients are BCR/ABL1 negative.

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Blood outgrowth endothelial cells from chronic myeloid leukaemia patients are BCR/ABL1 negative. / Wellbrock, Jasmin; Schultze, Alexander; Schafhausen, Philippe; Otterstetter, Svenja; Dierlamm, Judith; Bokemeyer, Carsten; Brümmendorf, Tim; Fiedler, Walter; Loges, Sonja.

in: BRIT J HAEMATOL, Jahrgang 142, Nr. 1, 1, 2008, S. 115-118.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wellbrock, J, Schultze, A, Schafhausen, P, Otterstetter, S, Dierlamm, J, Bokemeyer, C, Brümmendorf, T, Fiedler, W & Loges, S 2008, 'Blood outgrowth endothelial cells from chronic myeloid leukaemia patients are BCR/ABL1 negative.', BRIT J HAEMATOL, Jg. 142, Nr. 1, 1, S. 115-118. <http://www.ncbi.nlm.nih.gov/pubmed/18477035?dopt=Citation>

APA

Wellbrock, J., Schultze, A., Schafhausen, P., Otterstetter, S., Dierlamm, J., Bokemeyer, C., Brümmendorf, T., Fiedler, W., & Loges, S. (2008). Blood outgrowth endothelial cells from chronic myeloid leukaemia patients are BCR/ABL1 negative. BRIT J HAEMATOL, 142(1), 115-118. [1]. http://www.ncbi.nlm.nih.gov/pubmed/18477035?dopt=Citation

Vancouver

Wellbrock J, Schultze A, Schafhausen P, Otterstetter S, Dierlamm J, Bokemeyer C et al. Blood outgrowth endothelial cells from chronic myeloid leukaemia patients are BCR/ABL1 negative. BRIT J HAEMATOL. 2008;142(1):115-118. 1.

Bibtex

@article{44d395725e52474cbac1001fe5a4ad3b,
title = "Blood outgrowth endothelial cells from chronic myeloid leukaemia patients are BCR/ABL1 negative.",
abstract = "The existence of adult haemangioblasts with dual haematopoietic and endothelial developmental potential was confirmed after detection of Ph(+) vascular endothelial cells in chronic myeloid leukaemia (CML) patients. Blood outgrowth endothelial cells (OECs) from CML patients were found not to harbour the Philadelphia translocation and were thus not clonally related to BRC/ABL1(+) hematopoietic progenitors, but comprised a distinct subfraction of endothelial cells. Remarkably, the frequency of CML-derived OECs was 9-fold higher as compared to healthy donors (n = 19 and n = 300, respectively; P <0.0001) and these cells showed increased proliferative potential, possibly reflecting the mobilisation of OEC progenitors by pro-angiogenic cytokines.",
author = "Jasmin Wellbrock and Alexander Schultze and Philippe Schafhausen and Svenja Otterstetter and Judith Dierlamm and Carsten Bokemeyer and Tim Br{\"u}mmendorf and Walter Fiedler and Sonja Loges",
year = "2008",
language = "Deutsch",
volume = "142",
pages = "115--118",
journal = "BRIT J HAEMATOL",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Blood outgrowth endothelial cells from chronic myeloid leukaemia patients are BCR/ABL1 negative.

AU - Wellbrock, Jasmin

AU - Schultze, Alexander

AU - Schafhausen, Philippe

AU - Otterstetter, Svenja

AU - Dierlamm, Judith

AU - Bokemeyer, Carsten

AU - Brümmendorf, Tim

AU - Fiedler, Walter

AU - Loges, Sonja

PY - 2008

Y1 - 2008

N2 - The existence of adult haemangioblasts with dual haematopoietic and endothelial developmental potential was confirmed after detection of Ph(+) vascular endothelial cells in chronic myeloid leukaemia (CML) patients. Blood outgrowth endothelial cells (OECs) from CML patients were found not to harbour the Philadelphia translocation and were thus not clonally related to BRC/ABL1(+) hematopoietic progenitors, but comprised a distinct subfraction of endothelial cells. Remarkably, the frequency of CML-derived OECs was 9-fold higher as compared to healthy donors (n = 19 and n = 300, respectively; P <0.0001) and these cells showed increased proliferative potential, possibly reflecting the mobilisation of OEC progenitors by pro-angiogenic cytokines.

AB - The existence of adult haemangioblasts with dual haematopoietic and endothelial developmental potential was confirmed after detection of Ph(+) vascular endothelial cells in chronic myeloid leukaemia (CML) patients. Blood outgrowth endothelial cells (OECs) from CML patients were found not to harbour the Philadelphia translocation and were thus not clonally related to BRC/ABL1(+) hematopoietic progenitors, but comprised a distinct subfraction of endothelial cells. Remarkably, the frequency of CML-derived OECs was 9-fold higher as compared to healthy donors (n = 19 and n = 300, respectively; P <0.0001) and these cells showed increased proliferative potential, possibly reflecting the mobilisation of OEC progenitors by pro-angiogenic cytokines.

M3 - SCORING: Zeitschriftenaufsatz

VL - 142

SP - 115

EP - 118

JO - BRIT J HAEMATOL

JF - BRIT J HAEMATOL

SN - 0007-1048

IS - 1

M1 - 1

ER -