Biogenesis of tail-anchored proteins: the beginning for the end?
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Biogenesis of tail-anchored proteins: the beginning for the end? / Rabu, Catherine; Schmid, Volker; Schwappach, Blanche; High, Stephen.
In: J CELL SCI, Vol. 122, No. Pt 20, 15.10.2009, p. 3605-12.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Biogenesis of tail-anchored proteins: the beginning for the end?
AU - Rabu, Catherine
AU - Schmid, Volker
AU - Schwappach, Blanche
AU - High, Stephen
PY - 2009/10/15
Y1 - 2009/10/15
N2 - Tail-anchored proteins are a distinct class of integral membrane proteins located in several eukaryotic organelles, where they perform a diverse range of functions. These proteins have in common the C-terminal location of their transmembrane anchor and the resulting post-translational nature of their membrane insertion, which, unlike the co-translational membrane insertion of most other proteins, is not coupled to ongoing protein synthesis. The study of tail-anchored proteins has provided a paradigm for understanding the components and pathways that mediate post-translational biogenesis of membrane proteins at the endoplasmic reticulum. In this Commentary, we review recent studies that have converged at a consensus regarding the molecular mechanisms that underlie this process--namely, that multiple pathways underlie the biogenesis of tail-anchored proteins at the endoplasmic reticulum.
AB - Tail-anchored proteins are a distinct class of integral membrane proteins located in several eukaryotic organelles, where they perform a diverse range of functions. These proteins have in common the C-terminal location of their transmembrane anchor and the resulting post-translational nature of their membrane insertion, which, unlike the co-translational membrane insertion of most other proteins, is not coupled to ongoing protein synthesis. The study of tail-anchored proteins has provided a paradigm for understanding the components and pathways that mediate post-translational biogenesis of membrane proteins at the endoplasmic reticulum. In this Commentary, we review recent studies that have converged at a consensus regarding the molecular mechanisms that underlie this process--namely, that multiple pathways underlie the biogenesis of tail-anchored proteins at the endoplasmic reticulum.
KW - Animals
KW - Endoplasmic Reticulum/metabolism
KW - Golgi Apparatus/metabolism
KW - Heat-Shock Proteins/metabolism
KW - Humans
KW - Membrane Proteins/biosynthesis
KW - Protein Transport
KW - Signal Recognition Particle/metabolism
U2 - 10.1242/jcs.041210
DO - 10.1242/jcs.041210
M3 - SCORING: Review article
C2 - 19812306
VL - 122
SP - 3605
EP - 3612
JO - J CELL SCI
JF - J CELL SCI
SN - 0021-9533
IS - Pt 20
ER -