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Biogenesis of tail-anchored proteins: the beginning for the end?

Standard

Biogenesis of tail-anchored proteins: the beginning for the end? / Rabu, Catherine; Schmid, Volker; Schwappach, Blanche; High, Stephen.

in: J CELL SCI, Jahrgang 122, Nr. Pt 20, 15.10.2009, S. 3605-12.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Rabu, C, Schmid, V, Schwappach, B & High, S 2009, 'Biogenesis of tail-anchored proteins: the beginning for the end?', J CELL SCI, Jg. 122, Nr. Pt 20, S. 3605-12. https://doi.org/10.1242/jcs.041210

APA

Rabu, C., Schmid, V., Schwappach, B., & High, S. (2009). Biogenesis of tail-anchored proteins: the beginning for the end? J CELL SCI, 122(Pt 20), 3605-12. https://doi.org/10.1242/jcs.041210

Vancouver

Rabu C, Schmid V, Schwappach B, High S. Biogenesis of tail-anchored proteins: the beginning for the end? J CELL SCI. 2009 Okt 15;122(Pt 20):3605-12. https://doi.org/10.1242/jcs.041210

Bibtex

@article{58e55435661246ac817d274049d0a5da,
title = "Biogenesis of tail-anchored proteins: the beginning for the end?",
abstract = "Tail-anchored proteins are a distinct class of integral membrane proteins located in several eukaryotic organelles, where they perform a diverse range of functions. These proteins have in common the C-terminal location of their transmembrane anchor and the resulting post-translational nature of their membrane insertion, which, unlike the co-translational membrane insertion of most other proteins, is not coupled to ongoing protein synthesis. The study of tail-anchored proteins has provided a paradigm for understanding the components and pathways that mediate post-translational biogenesis of membrane proteins at the endoplasmic reticulum. In this Commentary, we review recent studies that have converged at a consensus regarding the molecular mechanisms that underlie this process--namely, that multiple pathways underlie the biogenesis of tail-anchored proteins at the endoplasmic reticulum.",
keywords = "Animals, Endoplasmic Reticulum/metabolism, Golgi Apparatus/metabolism, Heat-Shock Proteins/metabolism, Humans, Membrane Proteins/biosynthesis, Protein Transport, Signal Recognition Particle/metabolism",
author = "Catherine Rabu and Volker Schmid and Blanche Schwappach and Stephen High",
year = "2009",
month = oct,
day = "15",
doi = "10.1242/jcs.041210",
language = "English",
volume = "122",
pages = "3605--12",
journal = "J CELL SCI",
issn = "0021-9533",
publisher = "Company of Biologists Ltd",
number = "Pt 20",

}

RIS

TY - JOUR

T1 - Biogenesis of tail-anchored proteins: the beginning for the end?

AU - Rabu, Catherine

AU - Schmid, Volker

AU - Schwappach, Blanche

AU - High, Stephen

PY - 2009/10/15

Y1 - 2009/10/15

N2 - Tail-anchored proteins are a distinct class of integral membrane proteins located in several eukaryotic organelles, where they perform a diverse range of functions. These proteins have in common the C-terminal location of their transmembrane anchor and the resulting post-translational nature of their membrane insertion, which, unlike the co-translational membrane insertion of most other proteins, is not coupled to ongoing protein synthesis. The study of tail-anchored proteins has provided a paradigm for understanding the components and pathways that mediate post-translational biogenesis of membrane proteins at the endoplasmic reticulum. In this Commentary, we review recent studies that have converged at a consensus regarding the molecular mechanisms that underlie this process--namely, that multiple pathways underlie the biogenesis of tail-anchored proteins at the endoplasmic reticulum.

AB - Tail-anchored proteins are a distinct class of integral membrane proteins located in several eukaryotic organelles, where they perform a diverse range of functions. These proteins have in common the C-terminal location of their transmembrane anchor and the resulting post-translational nature of their membrane insertion, which, unlike the co-translational membrane insertion of most other proteins, is not coupled to ongoing protein synthesis. The study of tail-anchored proteins has provided a paradigm for understanding the components and pathways that mediate post-translational biogenesis of membrane proteins at the endoplasmic reticulum. In this Commentary, we review recent studies that have converged at a consensus regarding the molecular mechanisms that underlie this process--namely, that multiple pathways underlie the biogenesis of tail-anchored proteins at the endoplasmic reticulum.

KW - Animals

KW - Endoplasmic Reticulum/metabolism

KW - Golgi Apparatus/metabolism

KW - Heat-Shock Proteins/metabolism

KW - Humans

KW - Membrane Proteins/biosynthesis

KW - Protein Transport

KW - Signal Recognition Particle/metabolism

U2 - 10.1242/jcs.041210

DO - 10.1242/jcs.041210

M3 - SCORING: Review article

C2 - 19812306

VL - 122

SP - 3605

EP - 3612

JO - J CELL SCI

JF - J CELL SCI

SN - 0021-9533

IS - Pt 20

ER -